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Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Letter

Benefit of prokinetics during enteral nutrition: still searching for a piece of evidence

Author: Alain Dive

Published in: Critical Care | Issue 1/2016

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Excerpt

I read with interest the article by Lewis et al. [1] who presents a review and meta-analysis of randomized controlled trials (RCTs) examining the benefit and harms of prokinetics in patients receiving enteral nutrition. They used the Grading of recommendation, assessment, development, and evaluation (GRADE) method to assess the quality of evidence for various clinical outcomes including feeding tolerance, success of postpyloric placement tubes, pneumonia, mortality, vomiting, and diarrhoea. …
Literature
1.
Lewis K, Alqahtani Z, McIntyre L, Almenawer S, Alshamsi F, Rhodes A, Evans L, Angus DC, Alhazzani W. The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials. Crit Care. 2016;20:259.CrossRefPubMedPubMedCentral
2.
Elke G, Felbinger TW, Heyland DK. Gastric residual volume in critically ill patients: a dead marker or still alive? Nutr Clin Pract. 2015;30:59–71.CrossRefPubMed
3.
Nguyen NQ, Ching K, Fraser RJ, Chapman MJ, Holloway RH. Risk of clostridium difficile diarrhoea in critically ill patients treated with erythromycin-based prokinetic therapy for feed intolerance. Intensive Care Med. 2008;34:169–73.CrossRefPubMed
4.
Deane A, Wong G, Horowitz M, Zaknic A, Summers M, Di Bartolomeo A, Sim J, Maddox A, Bellon M, Rayner C, Chapman M, Fraser R. Randomized double-blind crossover study to determine the effects of erythromycin on small intestinal nutrient absorption and transit in the critically ill. Am J Nutr. 2012;95:1396–402.CrossRef
Metadata
Title
Benefit of prokinetics during enteral nutrition: still searching for a piece of evidence
Author
Alain Dive
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1502-3

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