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Published in: Critical Care 1/2016

Open Access 01-12-2016 | Research

Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival

Authors: Malvin Torsvik, Lise Tuset Gustad, Arne Mehl, Inger Lise Bangstad, Liv Jorun Vinje, Jan Kristian Damås, Erik Solligård

Published in: Critical Care | Issue 1/2016

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Abstract

Background

Systemic inflammatory response syndrome (SIRS) and sepsis are now frequently identified by observations of vital signs and detection of organ failure during triage in the emergency room. However, there is less focus on the effect on patient outcome with better observation and treatment at the ward level.

Methods

This was a before-and-after intervention study in one emergency and community hospital within the Mid-Norway Sepsis Study catchment area. All patients with confirmed bloodstream infection have been prospectively registered continuously since 1994. Severity of sepsis, observation frequency of vital signs, treatment data, length of stay (LOS) in high dependency and intensive care units, and mortality were retrospectively registered from the patients’ medical journals.

Results

The post-intervention group (n = 409) were observed better and had higher odds of surviving 30 days (OR 2.7, 95 % CI 1.6, 4.6), lower probability of developing severe organ failure (0.7, 95 % CI 0.4, 0.9), and on average, 3.7 days (95 % CI 1.5, 5.9 days) shorter LOS than the pre-intervention group (n = 472).

Conclusions

In a cohort with stable mortality rates, early sepsis recognition by ward nurses may have reduced progression of disease and improved survival for patients in hospital with sepsis.
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Literature
2.
go back to reference Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004;32(3):858–73.CrossRefPubMed Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004;32(3):858–73.CrossRefPubMed
3.
go back to reference Levy MM, Rhodes A, Phillips GS, Townsend SR, Schorr CA, Beale R, Osborn T, Lemeshow S, Chiche JD, Artigas A, et al. Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Crit Care Med. 2015;43(1):3–12.CrossRefPubMed Levy MM, Rhodes A, Phillips GS, Townsend SR, Schorr CA, Beale R, Osborn T, Lemeshow S, Chiche JD, Artigas A, et al. Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Crit Care Med. 2015;43(1):3–12.CrossRefPubMed
4.
go back to reference Dellinger RP. Foreword. The future of sepsis performance improvement. Crit Care Med. 2015;43(9):1787–9.CrossRefPubMed Dellinger RP. Foreword. The future of sepsis performance improvement. Crit Care Med. 2015;43(9):1787–9.CrossRefPubMed
5.
go back to reference Kenzaka T, Okayama M, Kuroki S, Fukui M, Yahata S, Hayashi H, Kitao A, Sugiyama D, Kajii E, Hashimoto M. Importance of vital signs to the early diagnosis and severity of sepsis: association between vital signs and sequential organ failure assessment score in patients with sepsis. Intern Med. 2012;51(8):871–6.CrossRefPubMed Kenzaka T, Okayama M, Kuroki S, Fukui M, Yahata S, Hayashi H, Kitao A, Sugiyama D, Kajii E, Hashimoto M. Importance of vital signs to the early diagnosis and severity of sepsis: association between vital signs and sequential organ failure assessment score in patients with sepsis. Intern Med. 2012;51(8):871–6.CrossRefPubMed
6.
go back to reference Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644–55.CrossRefPubMed Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644–55.CrossRefPubMed
7.
go back to reference Robson W, Beavis S, Spittle N. An audit of ward nurses' knowledge of sepsis. Nurs Crit Care. 2007;12(2):86–92.CrossRefPubMed Robson W, Beavis S, Spittle N. An audit of ward nurses' knowledge of sepsis. Nurs Crit Care. 2007;12(2):86–92.CrossRefPubMed
8.
go back to reference Mehl A, Harthug S, Lydersen S, Paulsen J, Asvold BO, Solligard E, Damas JK, Edna TH. Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study. Eur J Clin Microbiol Infect Dis. 2015;34(3):609–17.CrossRefPubMed Mehl A, Harthug S, Lydersen S, Paulsen J, Asvold BO, Solligard E, Damas JK, Edna TH. Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study. Eur J Clin Microbiol Infect Dis. 2015;34(3):609–17.CrossRefPubMed
9.
go back to reference Haug JB, Harthug S, Kalager T, Digranes A, Solberg CO. Bloodstream infections at a Norwegian university hospital, 1974–1979 and 1988–1989: changing etiology, clinical features, and outcome. Clin Infect Dis. 1994;19(2):246–56.CrossRefPubMed Haug JB, Harthug S, Kalager T, Digranes A, Solberg CO. Bloodstream infections at a Norwegian university hospital, 1974–1979 and 1988–1989: changing etiology, clinical features, and outcome. Clin Infect Dis. 1994;19(2):246–56.CrossRefPubMed
10.
go back to reference Aiken LH, Clarke SP, Sloane DM, Sochalski J, Silber JH. Hospital nurse staffing and patient mortality, nurse burnout, and job dissatisfaction. JAMA. 2002;288(16):1987–93.CrossRefPubMed Aiken LH, Clarke SP, Sloane DM, Sochalski J, Silber JH. Hospital nurse staffing and patient mortality, nurse burnout, and job dissatisfaction. JAMA. 2002;288(16):1987–93.CrossRefPubMed
11.
go back to reference Vincent JL, de Mendonca A, Cantraine F, Moreno R, Takala J, Suter PM, Sprung CL, Colardyn F, Blecher S. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med. 1998;26(11):1793–800.CrossRefPubMed Vincent JL, de Mendonca A, Cantraine F, Moreno R, Takala J, Suter PM, Sprung CL, Colardyn F, Blecher S. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med. 1998;26(11):1793–800.CrossRefPubMed
12.
go back to reference McCabe WR. Antibody to endotoxin in the treatment of gram-negative sepsis. JAMA. 1992;267(17):2325.CrossRefPubMed McCabe WR. Antibody to endotoxin in the treatment of gram-negative sepsis. JAMA. 1992;267(17):2325.CrossRefPubMed
13.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.CrossRefPubMed
14.
go back to reference Friedman ND, Kaye KS, Stout JE, McGarry SA, Trivette SL, Briggs JP, Lamm W, Clark C, MacFarquhar J, Walton AL, et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med. 2002;137(10):791–7.CrossRefPubMed Friedman ND, Kaye KS, Stout JE, McGarry SA, Trivette SL, Briggs JP, Lamm W, Clark C, MacFarquhar J, Walton AL, et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med. 2002;137(10):791–7.CrossRefPubMed
15.
go back to reference Shorr AF, Tabak YP, Killian AD, Gupta V, Liu LZ, Kollef MH. Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database. Crit Care Med. 2006;34(10):2588–95.CrossRefPubMed Shorr AF, Tabak YP, Killian AD, Gupta V, Liu LZ, Kollef MH. Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database. Crit Care Med. 2006;34(10):2588–95.CrossRefPubMed
16.
go back to reference Dickinson JD, Kollef MH. Early and adequate antibiotic therapy in the treatment of severe sepsis and septic shock. Curr Infect Dis Rep. 2011;13(5):399–405.CrossRefPubMed Dickinson JD, Kollef MH. Early and adequate antibiotic therapy in the treatment of severe sepsis and septic shock. Curr Infect Dis Rep. 2011;13(5):399–405.CrossRefPubMed
17.
go back to reference Levy MM, Fink MP, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. 2003;29:530–8.CrossRefPubMed Levy MM, Fink MP, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. 2003;29:530–8.CrossRefPubMed
18.
go back to reference Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41(2):580–637.CrossRefPubMed Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41(2):580–637.CrossRefPubMed
19.
go back to reference Stevenson EK, Rubenstein AR, Radin GT, Wiener RS, Walkey AJ. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis. Crit Care Med. 2014;42(3):625–31.CrossRefPubMedPubMedCentral Stevenson EK, Rubenstein AR, Radin GT, Wiener RS, Walkey AJ. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis. Crit Care Med. 2014;42(3):625–31.CrossRefPubMedPubMedCentral
20.
go back to reference Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA. 2014;311(13):1308–16.CrossRefPubMed Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000–2012. JAMA. 2014;311(13):1308–16.CrossRefPubMed
21.
go back to reference Paulsen J, Mehl A, Askim A, Solligard E, Asvold BO, Damas JK. Epidemiology and outcome of Staphylococcus aureus bloodstream infection and sepsis in a Norwegian county 1996–2011: an observational study. BMC Infect Dis. 2015;15:116.CrossRefPubMedPubMedCentral Paulsen J, Mehl A, Askim A, Solligard E, Asvold BO, Damas JK. Epidemiology and outcome of Staphylococcus aureus bloodstream infection and sepsis in a Norwegian county 1996–2011: an observational study. BMC Infect Dis. 2015;15:116.CrossRefPubMedPubMedCentral
22.
go back to reference Askim A, Mehl A, Paulsen J, DeWan AT, Vestrheim DF, Asvold BO, Damas JK, Solligard E. Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993–2011: an observational study. BMC Infect Dis. 2016;16(1):223.CrossRefPubMedPubMedCentral Askim A, Mehl A, Paulsen J, DeWan AT, Vestrheim DF, Asvold BO, Damas JK, Solligard E. Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993–2011: an observational study. BMC Infect Dis. 2016;16(1):223.CrossRefPubMedPubMedCentral
23.
go back to reference Levy MM, Rhodes A, Phillips GS, Townsend SR, Schorr CA, Beale R, Osborn T, Lemeshow S, Chiche JD, Artigas A, et al. Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Intensive Care Med. 2014;40(11):1623–33.CrossRefPubMed Levy MM, Rhodes A, Phillips GS, Townsend SR, Schorr CA, Beale R, Osborn T, Lemeshow S, Chiche JD, Artigas A, et al. Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Intensive Care Med. 2014;40(11):1623–33.CrossRefPubMed
24.
go back to reference Miller 3rd RR, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP. Intermountain Healthcare Intensive Medicine Clinical P. Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med. 2013;188(1):77–82.CrossRefPubMedPubMedCentral Miller 3rd RR, Dong L, Nelson NC, Brown SM, Kuttler KG, Probst DR, Allen TL, Clemmer TP. Intermountain Healthcare Intensive Medicine Clinical P. Multicenter implementation of a severe sepsis and septic shock treatment bundle. Am J Respir Crit Care Med. 2013;188(1):77–82.CrossRefPubMedPubMedCentral
25.
go back to reference Goyal J, Nuhn P, Huang P, Tyagi P, Oh D, Carducci MA, Eisenberger MA, Antonarakis ES. The effect of clinical trial participation versus non-participation on overall survival in men receiving first-line docetaxel-containing chemotherapy for metastatic castration-resistant prostate cancer. BJU Int. 2012;110(11 Pt B):575–82.CrossRef Goyal J, Nuhn P, Huang P, Tyagi P, Oh D, Carducci MA, Eisenberger MA, Antonarakis ES. The effect of clinical trial participation versus non-participation on overall survival in men receiving first-line docetaxel-containing chemotherapy for metastatic castration-resistant prostate cancer. BJU Int. 2012;110(11 Pt B):575–82.CrossRef
26.
go back to reference Selby P, Autier P. The impact of the process of clinical research on health service outcomes. Ann Oncol. 2011;22 Suppl 7:vii5–9.PubMed Selby P, Autier P. The impact of the process of clinical research on health service outcomes. Ann Oncol. 2011;22 Suppl 7:vii5–9.PubMed
27.
go back to reference Ghaferi AA, Dimick JB. Importance of teamwork, communication and culture on failure-to-rescue in the elderly. Br J Surg. 2016;103(2):e47–51.CrossRefPubMed Ghaferi AA, Dimick JB. Importance of teamwork, communication and culture on failure-to-rescue in the elderly. Br J Surg. 2016;103(2):e47–51.CrossRefPubMed
28.
go back to reference Castellanos-Ortega A, Suberviola B, Garcia-Astudillo LA, Holanda MS, Ortiz F, Llorca J, Delgado-Rodriguez M. Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study. Crit Care Med. 2010;38(4):1036–43.CrossRefPubMed Castellanos-Ortega A, Suberviola B, Garcia-Astudillo LA, Holanda MS, Ortiz F, Llorca J, Delgado-Rodriguez M. Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study. Crit Care Med. 2010;38(4):1036–43.CrossRefPubMed
29.
go back to reference Gao F, Melody T, Daniels DF, Giles S, Fox S. The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study. Crit Care. 2005;9(6):R764–70.CrossRefPubMedPubMedCentral Gao F, Melody T, Daniels DF, Giles S, Fox S. The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study. Crit Care. 2005;9(6):R764–70.CrossRefPubMedPubMedCentral
30.
go back to reference Nguyen HB, Corbett SW, Steele R, Banta J, Clark RT, Hayes SR, Edwards J, Cho TW, Wittlake WA. Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med. 2007;35(4):1105–12.CrossRefPubMed Nguyen HB, Corbett SW, Steele R, Banta J, Clark RT, Hayes SR, Edwards J, Cho TW, Wittlake WA. Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med. 2007;35(4):1105–12.CrossRefPubMed
31.
go back to reference Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801–10.CrossRefPubMedPubMedCentral Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801–10.CrossRefPubMedPubMedCentral
32.
go back to reference Strand K, Walther SM, Reinikainen M, Ala-Kokko T, Nolin T, Martner J, Mussalo P, Soreide E, Flaatten HK. Variations in the length of stay of intensive care unit nonsurvivors in three Scandinavian countries. Crit Care. 2010;14(5):R175.CrossRefPubMedPubMedCentral Strand K, Walther SM, Reinikainen M, Ala-Kokko T, Nolin T, Martner J, Mussalo P, Soreide E, Flaatten HK. Variations in the length of stay of intensive care unit nonsurvivors in three Scandinavian countries. Crit Care. 2010;14(5):R175.CrossRefPubMedPubMedCentral
33.
go back to reference Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29(7):1303–10.CrossRefPubMed Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29(7):1303–10.CrossRefPubMed
34.
go back to reference Churpek MM, Zadravecz FJ, Winslow C, Howell MD, Edelson DP. Incidence and prognostic value of the systemic inflammatory response syndrome and organ dysfunctions in ward patients. Am J Respir Crit Care Med. 2015;192(8):958–64.CrossRefPubMedPubMedCentral Churpek MM, Zadravecz FJ, Winslow C, Howell MD, Edelson DP. Incidence and prognostic value of the systemic inflammatory response syndrome and organ dysfunctions in ward patients. Am J Respir Crit Care Med. 2015;192(8):958–64.CrossRefPubMedPubMedCentral
35.
go back to reference Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. New Engl J Med. 2015;372(17):1629–38.CrossRefPubMed Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. New Engl J Med. 2015;372(17):1629–38.CrossRefPubMed
36.
go back to reference Andrews T, Waterman H. Packaging: a grounded theory of how to report physiological deterioration effectively. J Adv Nurs. 2005;52(5):473–81.CrossRefPubMed Andrews T, Waterman H. Packaging: a grounded theory of how to report physiological deterioration effectively. J Adv Nurs. 2005;52(5):473–81.CrossRefPubMed
37.
go back to reference Aitken LM, Williams G, Harvey M, Blot S, Kleinpell R, Labeau S, Marshall A, Ray-Barruel G, Moloney-Harmon PA, Robson W, et al. Nursing considerations to complement the Surviving Sepsis Campaign guidelines. Crit Care Med. 2011;39(7):1800–18.CrossRefPubMed Aitken LM, Williams G, Harvey M, Blot S, Kleinpell R, Labeau S, Marshall A, Ray-Barruel G, Moloney-Harmon PA, Robson W, et al. Nursing considerations to complement the Surviving Sepsis Campaign guidelines. Crit Care Med. 2011;39(7):1800–18.CrossRefPubMed
38.
go back to reference Burney M, Underwood J, McEvoy S, Nelson G, Dzierba A, Kauari V, Chong D. Early detection and treatment of severe sepsis in the emergency department: identifying barriers to implementation of a protocol-based approach. J Emerg Nurs. 2012;38(6):512–7.CrossRefPubMed Burney M, Underwood J, McEvoy S, Nelson G, Dzierba A, Kauari V, Chong D. Early detection and treatment of severe sepsis in the emergency department: identifying barriers to implementation of a protocol-based approach. J Emerg Nurs. 2012;38(6):512–7.CrossRefPubMed
39.
go back to reference Ansell H, Meyer A, Thompson S. Why don't nurses consistently take patient respiratory rates? Br J Nurs. 2014;23(8):414–8.CrossRefPubMed Ansell H, Meyer A, Thompson S. Why don't nurses consistently take patient respiratory rates? Br J Nurs. 2014;23(8):414–8.CrossRefPubMed
Metadata
Title
Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival
Authors
Malvin Torsvik
Lise Tuset Gustad
Arne Mehl
Inger Lise Bangstad
Liv Jorun Vinje
Jan Kristian Damås
Erik Solligård
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1423-1

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