Published in:
Open Access
01-12-2016 | Letter
From bedside to bench: the missing brick for patients with fungal sepsis
Authors:
Vincenzo Russotto, Andrea Cortegiani, Santi Maurizio Raineri, Antonino Giarratano
Published in:
Critical Care
|
Issue 1/2016
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Excerpt
We read with great interest the article by Spec et al. [
1] investigating the immunophenotype of T cells from patients with
Candida spp. sepsis. This is the first observational study describing the altered immune response of patients with candidemia. The authors included non-neutropenic critically ill patients with candidemia and non-septic controls, and excluded patients with human immunodeficiency virus infection, who had undergone solid or bone marrow transplantation or with other known causes of impaired immune response. The authors hypothesized that their findings may help explain why patients with fungal sepsis show a high mortality despite appropriate antifungal therapy. …
