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Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Commentary

Surrogate endpoints and competing risk of death in cardiac arrest research

Authors: Victoria A. McCredie, Damon C. Scales

Published in: Critical Care | Issue 1/2016

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Abstract

We urgently need new therapies to improve outcomes after cardiac arrest. Initial studies typically target surrogate endpoints, and these studies help to inform subsequent larger trials that are powered to measure more patient-orientated clinical outcomes such as survival. The competing risk of death and premature assessment of neurological prognosis pose significant challenges to measuring these surrogate endpoints after cardiac arrest.
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Metadata
Title
Surrogate endpoints and competing risk of death in cardiac arrest research
Authors
Victoria A. McCredie
Damon C. Scales
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1345-y

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