Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Review

Detrimental cross-talk between sepsis and acute kidney injury: new pathogenic mechanisms, early biomarkers and targeted therapies

Authors: Sergio Dellepiane, Marita Marengo, Vincenzo Cantaluppi

Published in: Critical Care | Issue 1/2016

Login to get access

Abstract

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at http://​www.​biomedcentral.​com/​collections/​annualupdate2016​. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://​www.​springer.​com/​series/​8901.
Literature
1.
Gomez H, Ince C, De Backer D, et al. A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury. Shock. 2014;41:3–11.CrossRefPubMedPubMedCentral
2.
Glodowski SD, Wagener G, et al. New insights into the mechanisms of acute kidney injury in the intensive care unit. J Clin Anesth. 2015;27:175–80.CrossRefPubMed
3.
Murugan R, Karajala-Subramanyam V, Lee M, et al. Genetic and Inflammatory Markers of Sepsis (GenIMS) Investigators: acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int. 2010;77:527–35.CrossRefPubMedPubMedCentral
4.
Lerolle N, Nochy D, Guérot E, et al. Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med. 2010;36:471–8.CrossRefPubMed
5.
Di Giantomasso D, May CN, Bellomo R. Vital organ blood flow during hyperdynamic sepsis. Chest. 2003;124:1053–9.CrossRefPubMed
6.
Brenner M, Schaer GL, Mallory DL, Suffredini AF, Parrillo JE. Detection of renal blood flow abnormalities in septic and critically ill patients using a newly designed indwelling thermodilution renal vein catheter. Chest. 1990;98:170–9.CrossRefPubMed
7.
Mariano F, Cantaluppi V, Stella M, et al. Circulating plasma factors induce tubular and glomerular alterations in septic burns patients. Crit Care. 2008;12:R42.CrossRefPubMedPubMedCentral
8.
Di Giantomasso D, Morimatsu H, May CN, Bellomo R. Intrarenal blood flow distribution in hyperdynamic septic shock: Effect of norepinephrine. Crit Care Med. 2003;31:2509–13.CrossRefPubMed
9.
Holthoff JH, Wang Z, Seely KA, Gokden N, Mayeux PR. Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury. Kidney Int. 2012;81:370–8.CrossRefPubMedPubMedCentral
10.
Legrand M, Dupuis C, Simon C, et al. Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study. Crit Care. 2013;17:R278.CrossRefPubMedPubMedCentral
11.
12.
Taniguchi T, Kurita A, Kobayashi K, Yamamoto K, Inaba H. Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats. J Anesth. 2008;22:221–8.CrossRefPubMed
13.
14.
Cantaluppi V, Quercia AD, Dellepiane S, Ferrario S, Camussi G, Biancone L. Interaction between systemic inflammation and renal tubular epithelial cells. Nephrol Dial Transplant. 2014;29:2004–11.CrossRefPubMed
15.
Cho E, Lee JH, Lim HJ, et al. Soluble CD25 is increased in patients with sepsis-induced acute kidney injury. Nephrol Carlton Vic. 2014;19:318–24.CrossRef
16.
Panacek EA, Marshall JC, Albertson TE, et al. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab’)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med. 2014;32:2173–82.CrossRef
17.
Yang R, Wang X, Liu D, Liu S. Energy and oxygen metabolism disorder during septic acute kidney injury. Kidney Blood Press Res. 2014;39:240–51.PubMed
18.
Gocze I, Koch M, Renner P, et al. Urinary biomarkers TIMP-2 and IGFBP7 early predict acute kidney injury after major surgery. PLoS One. 2015;10:e0120863.CrossRefPubMedPubMedCentral
19.
Kalakeche R, Hato T, Rhodes G, et al. Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment. J Am Soc Nephrol. 2011;22:1505–16.CrossRefPubMedPubMedCentral
20.
Naito M, Bomsztyk K, Zager RA. Endotoxin mediates recruitment of RNA polymerase II to target genes in acute renal failure. J Am Soc Nephrol. 2008;19:1321–30.CrossRefPubMedPubMedCentral
21.
Lentini P, de Cal M, Clementi A, D’Angelo A, Ronco C. Sepsis and AKI in ICU patients: the role of plasma biomarkers. Crit Care Res Pract. 2012;2012:856401.PubMedPubMedCentral
22.
Vanmassenhove J, Glorieux G, Lameire N, et al. Influence of severity of illness on neutrophil gelatinase-associated lipocalin performance as a marker of acute kidney injury: a prospective cohort study of patients with sepsis. BMC Nephrol. 2015;16:18.CrossRefPubMedPubMedCentral
23.
Si Nga H, Medeiros P, Menezes P, Bridi R, Balbi A, Ponce D. Sepsis and AKI in Clinical Emergency Room Patients: The Role of Urinary NGAL. BioMed Res Int. 2015;2015:413751.CrossRefPubMedCentral
24.
Su L, Feng L, Zhang J, et al. Diagnostic value of urine sTREM-1 for sepsis and relevant acute kidney injuries: a prospective study. Crit Care. 2011;15:R250.CrossRefPubMedPubMedCentral
25.
Bagshaw SM, Langenberg C, Haase M, Wan L, May CN, Bellomo R. Urinary biomarkers in septic acute kidney injury. Intensive Care Med. 2007;33:1285–96.CrossRefPubMed
26.
Sood MM, Shafer LA, Ho J, et al. Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group: Early reversible acute kidney injury is associated with improved survival in septic shock. J Crit Care. 2014;29:711–7.CrossRefPubMed
27.
Opal SM, Laterre P-F, Francois B, et al. ACCESS Study Group: Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA. 2013;309:1154–62.CrossRefPubMed
28.
29.
Pickkers P, Heemskerk S, Schouten J, et al. Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial. Crit Care. 2012;16:R14.CrossRefPubMedPubMedCentral
30.
Sardinha J, Kelly MEM, Zhou J, Lehmann C. Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis. Mediators Inflamm. 2014;2014:978678.CrossRefPubMedPubMedCentral
31.
Rosas-Ballina M, Olofsson PS, Ochani M, et al. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science. 2011;334:98–101.CrossRefPubMedPubMedCentral
32.
33.
Unsinger J, McGlynn M, Kasten KR, et al. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol. 2010;184:3768–79.CrossRefPubMedPubMedCentral
34.
Meisel C, Schefold JC, Pschowski R, et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med. 2009;180:640–8.CrossRefPubMed
35.
Barbar SD, Binquet C, Monchi M, Bruyère R, Quenot JP. Impact on mortality of the timing of renal replacement therapy in patients with severe acute kidney injury in septic shock: the IDEAL-ICU study (initiation of dialysis early versus delayed in the intensive care unit): study protocol for a randomized controlled trial. Trials. 2014;15:270.CrossRefPubMedPubMedCentral
36.
Sun Z, Ye H, Shen X, Chao H, Wu X, Yang J. Continuous venovenous hemofiltration versus extended daily hemofiltration in patients with septic acute kidney injury: a retrospective cohort study. Crit Care. 2014;18:R70.CrossRefPubMedPubMedCentral
37.
Ronco C, Bellomo R, Homel P, et al. Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet. 2000;356:26–30.CrossRefPubMed
38.
Bellomo R, Cass A, Cole L, et al. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009;361:1627–38.CrossRefPubMed
39.
Palevsky PM, Zhang JH, O’Connor TZ, et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008;359:7–20.CrossRefPubMed
40.
Joannes‐Boyau O, Honore PM, Perez P, et al. High‐volume versus standard volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicenter randomized controlled trial. Intensive Care Med. 2013;39:1535–46.CrossRefPubMed
41.
Honore PM, Jacobs R, Joannes-Boyau O, et al. Newly designed CRRT membranes for sepsis and SIRS – a pragmatic approach for bedside intensivists summarizing the more recent advances: a systematic structured review. ASAIO J. 2013;59:99–106.CrossRefPubMed
42.
Haase M, Bellomo R, Baldwin I, et al. Hemodialysis membrane with a high-molecular-weight cutoff and cytokine levels in sepsis complicated by acute renal failure: a phase 1 randomized trial. Am J Kidney Dis. 2007;50:296–304.CrossRefPubMed
43.
Winchester JF, Kellum JA, Ronco C, et al. Sorbents in acute renal failure and the systemic inflammatory response syndrome. Blood Purif. 2003;21:79–84.CrossRefPubMed
44.
45.
Cruz DN, Antonelli M, Fumagalli R, et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA. 2009;301:2445–52.CrossRefPubMed
46.
Klein DJ, Foster D, Schorr CA, Kazempour K, Walker PM, Dellinger RP. The EUPHRATES trial (Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock): study protocol for a randomized controlled trial. Trials. 2014;15:218.CrossRefPubMedPubMedCentral
47.
Yaroustovsky M, Abramyan M, Popok Z, et al. Preliminary report regarding the use of selective sorbents in complex cardiac surgery patients with extensive sepsis and prolonged intensive care stay. Blood Purif. 2009;28:227–33.CrossRefPubMed
48.
Peng Z-Y, Bishop JV, Wen X-Y, et al. Modulation of chemokine gradients by apheresis redirects leukocyte trafficking to different compartments during sepsis, studies in a rat model. Crit Care. 2014;18:R141.CrossRefPubMedPubMedCentral
49.
Livigni S, Bertolini G, Rossi C, et al. Efficacy of coupled plasma filtration adsorption (CPFA) in patients with septic shock: A multicenter randomised controlled clinical trial. BMJ Open. 2014;4:e003536.CrossRefPubMedPubMedCentral
50.
51.
Tumlin JA, Chawla L, Tolwani AJ, et al. The effect of the selective cytopheretic device on acute kidney injury outcomes in the intensive care unit: a multicenter pilot study. Semin Dial. 2013;26:616–23.CrossRefPubMed
52.
Camussi G, Cantaluppi V, Deregibus MC, Gatti E, Tetta C. Role of microvesicles in acute kidney injury. Contrib Nephrol. 2011;174:191–9.CrossRefPubMed
53.
Németh K, Leelahavanichkul A, Yuen PST, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med. 2009;15:42–9.CrossRefPubMedPubMedCentral
54.
Cribbs SK, Sutcliffe DJ, Taylor WR, et al. Circulating endothelial progenitor cells inversely associate with organ dysfunction in sepsis. Intensive Care Med. 2012;38:429–36.CrossRefPubMedPubMedCentral
55.
Camussi G, Deregibus MC, Bruno S, et al. Exosome/microvesicle-mediated epigenetic reprogramming of cells. Am J Cancer Res. 2011;1:98–110.PubMedPubMedCentral
56.
Bruno S, Grange C, Collino F, et al. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One. 2012;7:e33115.CrossRefPubMedPubMedCentral
57.
Cantaluppi V, Medica D, Mannari C, et al. Endothelial progenitor cell-derived extracellular vesicles protect from complement-mediated mesangial injury in experimental anti-Thy1.1 glomerulonephritis. Nephrol Dial Transplant. 2015;30:410–22.CrossRefPubMed
Metadata
Title
Detrimental cross-talk between sepsis and acute kidney injury: new pathogenic mechanisms, early biomarkers and targeted therapies
Authors
Sergio Dellepiane
Marita Marengo
Vincenzo Cantaluppi
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1219-3

Other articles of this Issue 1/2016

Critical Care 1/2016 Go to the issue

Review

The right ventricle: interaction with the pulmonary circulation

Research

Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis

Letter

Benefit of prokinetics during enteral nutrition: still searching for a piece of evidence

Letter

Fondaparinux: another potential treatment for heparin-induced thrombocytopenia type II?

Research

Correlation of maximal inspiratory pressure to transdiaphragmatic twitch pressure in intensive care unit patients

Research

Current real-life use of vasopressors and inotropes in cardiogenic shock - adrenaline use is associated with excess organ injury and mortality