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Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2015 | Letter

Stress ulcer prophylaxis in adult neurocritical care patients—no firm evidence for benefit or harm

Authors: Mette Krag, Anders Perner, Jørn Wetterslev, Morten Hylander Møller

Published in: Critical Care | Issue 1/2016

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Excerpt

In volume 19 (2015) of Critical Care, Liu et al. [1] present a systematic review of risks and benefits of stress ulcer prophylaxis (SUP) in adult neurocritical care patients. A total of eight randomised controlled trials (RCTs) on SUP with proton pump inhibitors or histamine-2 receptor antagonists versus placebo or no prophylaxis in neurocritical care patients was assessed. The authors conclude that SUP is superior to placebo/no prophylaxis in reducing gastrointestinal (GI) bleeding and all-cause mortality, while not increasing the risk of nosocomial pneumonia [1]. …
Literature
1.
Liu B, Liu S, Yin A, Siddiqi J. Risks and benefits of stress ulcer prophylaxis in adult neurocritical care patients: a systematic review and meta-analysis of randomized controlled trials. Crit Care. 2015;19:409.PubMedCentralCrossRefPubMed
2.
Brok J, Thorlund K, Gluud C, Wetterslev J. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol. 2008;61:763–9.CrossRefPubMed
3.
Savovic J, Jones HE, Altman DG, Harris RJ, Juni P, Pildal J, et al. Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Ann Intern Med. 2012;157:429–38.CrossRefPubMed
4.
Krag M, Perner A, Wetterslev J, Wise MP, Moller MH. Trials on stress ulcer prophylaxis: finding the balance between benefit and harm. Intensive Care Med. 2015;41:1367–8.CrossRefPubMed
5.
Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336:924–6.PubMedCentralCrossRefPubMed
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Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. Version 5.1.0. Oxford, UK: The Cochrane Collaboration; 2011.
7.
Higgins JPT, Deeks JJ, Altman DG. Chapter 16: Special topics in statistics. In: Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions. Version 5.1.0. Oxford, UK: The Cochrane Collaboration; 2011.
Metadata
Title
Stress ulcer prophylaxis in adult neurocritical care patients—no firm evidence for benefit or harm
Authors
Mette Krag
Anders Perner
Jørn Wetterslev
Morten Hylander Møller
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1188-6

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