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Critical Care
Published in: Critical Care 1/2015

Open Access 01-12-2015 | Viewpoint

Judging quality of current septic shock definitions and criteria

Authors: Manu Shankar-Hari, Guido Bertolini, Frank M. Brunkhorst, Rinaldo Bellomo, Djillali Annane, Clifford S. Deutschman, Mervyn Singer

Published in: Critical Care | Issue 1/2015

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Abstract

Septic shock definitions are being revisited. We assess the feasibility, reliability, and validity characteristics of the current definitions and criteria of septic shock. Septic shock is conceptualised as cardiovascular dysfunction, tissue perfusion and cellular abnormalities caused by infection. Currently, for feasibility, septic shock is identified at the bedside by using either hypotension or a proxy for tissue perfusion/cellular abnormalities (e.g., hyperlactatemia). We propose that concurrent presence of cardiovascular dysfunction and perfusion/cellular abnormalities could improve validity of septic shock diagnosis, as we are more likely to identify a patient population with all elements of the illness concept. This epidemiological refinement should not affect clinical care and may aid study design to identify illness-specific biomarkers and interventions.
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Metadata
Title
Judging quality of current septic shock definitions and criteria
Authors
Manu Shankar-Hari
Guido Bertolini
Frank M. Brunkhorst
Rinaldo Bellomo
Djillali Annane
Clifford S. Deutschman
Mervyn Singer
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-1164-6

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