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Critical Care
Published in: Critical Care 1/2015

Open Access 01-12-2015 | Research

Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis

Authors: Jun-wei Gao, An-qiang Zhang, Xiao Wang, Zhong-yun Li, Jian-hua Yang, Ling Zeng, Wei Gu, Jian-xin Jiang

Published in: Critical Care | Issue 1/2015

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Abstract

Introduction

Recently, researchers in a number of studies have explored the association between the Toll-like receptor 2 (TLR2) Arg753Gln polymorphism and sepsis risk. However, the results were conflicting. In this meta-analysis, we aimed to confirm the effect of the TLR2 Arg753Gln polymorphism on sepsis risk.

Methods

Relevant records up to 1 June 2015 were retrieved from the PubMed, Embase, and Web of Knowledge databases. The odds ratios with their corresponding 95 % confidence intervals were used to assess the association between the TLR2 Arg753Gln polymorphism and sepsis risk. The selection of a fixed or random effects model was made according to a heterogeneity test in total and subgroup analyses. Sensitivity analysis and publication bias test were performed to ensure the reliability of our results.

Results

A total of 12 studies with aggregate totals of 898 cases and 1517 controls met our inclusion criteria for meta-analysis. There were significant associations between the TLR2 Arg753Gln polymorphism and sepsis risk in overall analyses under two genetic models (the allele comparison and the dominant model). In addition, subgroup analyses based on age group, ethnicity, sepsis type, and source of control also showed a significant effect of the TLR2 Arg753Gln polymorphism on sepsis risk.

Conclusions

Our present meta-analysis supports a direct effect of the TLR2 Arg753Gln polymorphism on sepsis risk, especially in Europeans. The TLR2 Arg753Gln polymorphism might be used as a relevant risk estimate for the development of sepsis. Studies with larger sample sizes and homogeneous groups of patients with sepsis are required for further analysis.
Appendix
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Metadata
Title
Association between the TLR2 Arg753Gln polymorphism and the risk of sepsis: a meta-analysis
Authors
Jun-wei Gao
An-qiang Zhang
Xiao Wang
Zhong-yun Li
Jian-hua Yang
Ling Zeng
Wei Gu
Jian-xin Jiang
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-1130-3

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