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Critical Care
Published in: Critical Care 1/2015

Open Access 01-12-2015 | Research

Microvascular reactivity and clinical outcomes in cardiac surgery

Authors: Tae Kyong Kim, Youn Joung Cho, Jeong Jin Min, John M. Murkin, Jae-Hyon Bahk, Deok Man Hong, Yunseok Jeon

Published in: Critical Care | Issue 1/2015

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Abstract

Introduction

Microvascular reactivity is decreased in patients with septic shock; this is associated with worse clinical outcomes. The objectives of the present study were to investigate microvascular reactivity in cardiac surgery patients and to assess any association with clinical outcomes.

Methods

We retrospectively analyzed a prospectively collected registry. In total, 254 consecutive adult patients undergoing cardiac and thoracic aortic surgeries from January 2013 through May 2014 were analyzed. We performed a vascular occlusion test (VOT) by using near-infrared spectroscopy to measure microvascular reactivity. VOT was performed three times per patient: prior to the induction of anesthesia, at the end of surgery, and on postoperative day 1. The primary endpoint was a composite of major adverse complications, including death, myocardial infarction, acute kidney injury, acute respiratory distress syndrome, and persistent cardiogenic shock.

Results

VOT recovery slope decreased during the surgery. VOT recovery slope on postoperative day 1 was significantly lower in patients with composite complications than those without (3.1 ± 1.6 versus 4.0 ± 1.5 %/s, P = 0.001), although conventional hemodynamic values, such as cardiac output and blood pressure, did not differ between the groups. On multivariable regression and linear analyses, low VOT recovery slope on postoperative day 1 was associated with increases of composite complications (odds ratio 0.742; 95 % confidence interval (CI) 0.584 to 0.943; P = 0.015) and hospital length of stay (regression coefficient (B) −1.276; 95 % CI −2.440 to −0.112; P = 0.032).

Conclusion

Microvascular reactivity largely recovered on postoperative day 1 in the patients without composite complications, but this restoration was attenuated in patients with composite complications.

Trial registration

ClinicalTrials.gov NCT01713192. Registered 22 October 2012.
Appendix
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Metadata
Title
Microvascular reactivity and clinical outcomes in cardiac surgery
Authors
Tae Kyong Kim
Youn Joung Cho
Jeong Jin Min
John M. Murkin
Jae-Hyon Bahk
Deok Man Hong
Yunseok Jeon
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-1025-3

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