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Critical Care
Published in: Critical Care 6/2014

Open Access 01-12-2014 | Letter

Trained innate immunity as a mechanistic link between sepsis and atherosclerosis

Authors: Siroon Bekkering, Leo AB Joosten, Mihai G Netea, Niels P Riksen

Published in: Critical Care | Issue 6/2014

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Abstract

No abstract
Literature
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Kaynar AM, Yende S, Zhu L, Frederick DR, Chambers R, Burton CL, Carter M, Stolz DB, Agostini B, Gregory AD, Nagarajan S, Shapiro SD, Angus DC: Effects of intra-abdominal sepsis on atherosclerosis in mice. Crit Care. 2014, 18: 469-10.1186/s13054-014-0469-1.CrossRef
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Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JHA, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C, O’Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG: mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014, 345: 1250684-10.1126/science.1250684.CrossRef
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Quintin J, Saeed S, Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C, Jacobs L, Jansen T, Kullberg BJ, Wijmenga C, Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, Netea MG: Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host Microbe. 2012, 12: 223-232. 10.1016/j.chom.2012.06.006.CrossRef
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Bekkering S, Joosten LA, van der Meer JW, Netea MG, Riksen NP: Trained innate immunity and atherosclerosis. Curr Opin Lipidol. 2013, 24: 487-492. 10.1097/MOL.0000000000000023.CrossRef
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Bekkering S, Quintin J, Joosten LA, van der Meer JW, Netea MG, Riksen NP: Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes. Arterioscler Thromb Vasc Biol. 2014, 34: 1731-1738. 10.1161/ATVBAHA.114.303887.CrossRef
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Maitra U, Deng H, Glaros T, Baker B, Capelluto DG, Li Z, Li L: Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide. J Immunol. 2012, 189: 1014-1023. 10.4049/jimmunol.1200857.CrossRef
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Medzhitov R, Schneider DS, Soares MP: Disease tolerance as a defense strategy. Science. 2012, 335: 936-941. 10.1126/science.1214935.CrossRef
Metadata
Title
Trained innate immunity as a mechanistic link between sepsis and atherosclerosis
Authors
Siroon Bekkering
Leo AB Joosten
Mihai G Netea
Niels P Riksen
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-014-0645-3

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