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Critical Care
Published in: Critical Care 6/2014

Open Access 01-12-2014 | Commentary

Aging and the intramyocardial inflammatory response

Author: Keith R Walley

Published in: Critical Care | Issue 6/2014

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Abstract

The sepsis-induced intramyocardial inflammatory response results in decreased ventricular function and myocardial damage. Chemokines such as monocyte chemoattractant protein-1 causally contribute to retention of intramyocardial mononuclear leukocytes and subsequent ventricular dysfunction during endotoxemic shock in mice and, importantly, this effect is age dependent. It is therefore useful to consider where monocyte chemoattractant protein-1 fits in the complex pathway leading to ventricular dysfunction during sepsis, why this might be an age-dependent effect, and what this implies for care of older sepsis patients.
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Metadata
Title
Aging and the intramyocardial inflammatory response
Author
Keith R Walley
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-014-0638-2

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