Top

Published in:

Open Access 01-12-2022 | Myocarditis | Letter to the Editor

Protection against MIS-C outweighs the risk of myocarditis after Covid-19 vaccination in children

Authors: Marcello Mariani, Roberta Caorsi, Alessandro Consolaro, Giacomo Brisca, Camilla Sticchi, Marco Gattorno, Elio Castagnola, Angelo Ravelli

Published in: Italian Journal of Pediatrics | Issue 1/2022

Abstract

From March 2020 to July 2022, in Liguria region (North-West Italy) incidence of MIS-C among pediatric patients infected by SARS-CoV-2 was 38.7/100.000, which is higher than that of myocarditis after COVID-19 vaccination. In our opinion severity of MIS-C-related cardiac disease outweigh the risk of myocarditis after COVID-19 vaccine.

Dagan N, Barda N, Balicer RD. Adverse effects after BNT162b2 vaccine and SARS-CoV-2 infection, according to age and sex. N Engl J Med. 2021;2115045. https://doi.org/10.1056/nejmc2115045.

Gargano JW, Wallace M, Hadler SC, et al. Use of mRNA COVID-19 vaccine after reports of myocarditis among vaccine recipients: update from the advisory committee on immunization practices — United States, June 2021. MMWR Morb Mortal Wkly Rep. 2021;70:977–82. https://doi.org/10.15585/MMWR.MM7027E2.CrossRefPubMedPubMedCentral

Mevorach D, Anis E, Cedar N, et al. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. N Engl J Med. 2021:1–10. https://doi.org/10.1056/nejmoa2109730.

Frenck RW, Klein NP, Kitchin N, et al. Safety, immunogenicity, and efficacy of the BNT162b2 Covid-19 vaccine in adolescents. N Engl J Med. 2021;385:239–50. https://doi.org/10.1056/nejmoa2107456.CrossRefPubMed

Walter EB, Talaat KR, Sabharwal C, et al. Evaluation of the BNT162b2 Covid-19 vaccine in children 5 to 11 years of age. N Engl J Med. 2021:1–12. https://doi.org/10.1056/NEJMoa2116298.

Levin M. Childhood multisystem inflammatory syndrome — a new challenge in the pandemic. N Engl J Med. 2020;383:393–5. https://doi.org/10.1056/NEJME2023158/SUPPL_FILE/NEJME2023158_DISCLOSURES.PDF.CrossRefPubMed

Henderson LA, Canna SW, Friedman KG, et al. Information for healthcare providers about multisystem inflammatory syndrome in children (MIS-C). Arthritis Rheum. 2020;72:1791–805 https://www.cdc.gov/mis/mis-c/hcp/index.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fmis%2Fhcp%2Findex.html (Accessed 26 Nov 2021).CrossRef

McArdle AJ, Vito O, Patel H, et al. Treatment of multisystem inflammatory syndrome in children. N Engl J Med. 2021;385:11–22. https://doi.org/10.1056/nejmoa2102968.CrossRefPubMed

Son MBF, Murray N, Friedman K, et al. Multisystem inflammatory syndrome in children — initial therapy and outcomes. N Engl J Med. 2021;385:23–34. https://doi.org/10.1056/nejmoa2102605.CrossRefPubMed

10.

CDC. CDC COVID data tracker. Centers Dis Control Prev. 2020:7–11 https://covid.cdc.gov/covid-data-tracker/#mis-national-surveillance (Accessed 26 Nov 2021).

11.

Castagnola E, Mariani M, Sticchi C, et al. Incidence rate of MIS-C in paediatrics: a good reason to vaccinate children against SARS-CoV-2. Acta Paediatr Int J Paediatr. 2022;111:123–4. https://doi.org/10.1111/apa.16081.CrossRef

Title: Protection against MIS-C outweighs the risk of myocarditis after Covid-19 vaccination in children
Authors: Marcello Mariani
Roberta Caorsi
Alessandro Consolaro
Giacomo Brisca
Camilla Sticchi
Marco Gattorno
Elio Castagnola
Angelo Ravelli
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Myocarditis
COVID-19 Vaccination
SARS-CoV-2
Kawasaki Disease
Kawasaki Disease
Kawasaki Disease
Published in: Italian Journal of Pediatrics / Issue 1/2022
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/s13052-022-01335-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Protection against MIS-C outweighs the risk of myocarditis after Covid-19 vaccination in children

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2022

Retrospective longitudinal analysis of the effects of postnatal weight gain on the timing and tempo of puberty and menarche in a cohort of Italian girls

Correction: Epidemiological and clinical aspects of immunoglobulin A vasculitis in childhood: a retrospective cohort study

CHARGE syndrome presenting with persistent hypoglycemia: case report and overview of the main genetic syndromes associated with neonatal hypoglycemia

Eosinophil count and tumor necrosis factor α in response to phototherapy treatment of neonatal hyperbilirubinemia: a cross sectional study

Predicting immunoglobulin resistance in Kawasaki disease: an assessment of neutrophil to lymphocyte platelet ratio

Complementary feeding in preterm infants: a position paper by Italian neonatal, paediatric and paediatric gastroenterology joint societies