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Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2018

Open Access 01-12-2018 | Research

Fish oil-based lipid emulsion in the treatment of parenteral nutrition-associated cholestasis

Authors: Simonetta Costa, Rossella Iannotta, Luca Maggio, Giovanni Barone, Francesca Serrao, Giovanni Vento

Published in: Italian Journal of Pediatrics | Issue 1/2018

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Abstract

Background

Parenteral nutrition-associated cholestasis (PNAC) is a serious complication in preterm infants receiving prolonged parenteral nutrition. Soybean lipid emulsion (SLE) seems to have a role in its pathogenesis, whereas fish oil-based emulsion (FOLE) seems to be able to reverse cholestasis. This study aimed to evaluate the effectiveness of a FOLE in reversing PNAC.

Methods

The effectiveness in reversing PNAC was evaluated in prospective cohort study of very preterm infants when compared to historical controls: twenty-six infants (27.0 ± 2.6 weeks GA; 724 ± 204 g) who developed cholestasis while receiving SLE were shifted to receive FOLE and were compared with 30 infants (27.3 ± 2.5 weeks GA¸ 838 ± 277 g) who continued to receive SLE at diagnosis of cholestasis.

Results

Time to reversal of cholestasis was the same in the two study groups (45 ± 21 vs 43 ± 32 days).

Conclusions

FOLE does not seem to be superior to SLE in reversing cholestasis. Considering that definitive data on the actual efficacy of FOLE to reverse PNAC are lacking, larger randomized trials are required, mainly to asses if FOLE may have a role in PNAC prevention rather than PNAC treatment.
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Metadata
Title
Fish oil-based lipid emulsion in the treatment of parenteral nutrition-associated cholestasis
Authors
Simonetta Costa
Rossella Iannotta
Luca Maggio
Giovanni Barone
Francesca Serrao
Giovanni Vento
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2018
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-018-0539-0

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