Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2018

Open Access 01-12-2018 | Research

Vitamin D levels and parathyroid hormone variations of children living in a subtropical climate: a data mining study

Authors: Ozlem Naciye Sahin, Muhittin Serdar, Mustafa Serteser, Ibrahim Unsal, Aysel Ozpinar

Published in: Italian Journal of Pediatrics | Issue 1/2018

Login to get access

Abstract

Background

Vitamin D and intact parathyroid hormone (iPTH) play a crucial role in calcium homeostasis and bone health of children. Serum level of 25-hydroxyvitamin D (25-OHD) is considered to be the most accurate marker for vitamin D status. However, there have only been a few studies, with limited number of subjects, investigating the relationship between 25-OHD and parathyroid hormone (PTH) in children. The aim of this study was to evaluate the seasonal 25-OHD levels and its associations with intact parathyroid hormone (iPTH) in Turkish children at all pediatric ages; and then to define a critical decision threshold level for 25-OHD deficiency in Turkish children.

Methods

A retrospective record review of 90,042 children, was performed on serum 25-OHD and for 3525 iPTH levels. They were measured by mass spectrometry method and by electrochemiluminescence immunoassay simultaneously.

Results

25-OHD levels showed a sinusoidal fluctuation througout the year; being significantly higher in summer and autumn (p < 0,01). 25-OHD levels decreased with respect to age. The significant inverse relationship that was found between iPTH and 25-OHD suggests that the inflection point of serum 25-OHD level for maximal suppression of PTH is at 30 ng/ml.

Conclusion

As the rate of vitamin D deficiency decreases in the early years due to vitamin D supplementation, the recommendation should be set due to a clinical threshold level of 30 ng/ml for 25-OHD based on PTH levels in children of our population.
Literature
1.
Holick MF. Vitamin D status:measurement, interpretation and clinical application. Ann Epidemiol. 2009;19:73–8.CrossRefPubMed
2.
Misra M, Pacaud D, Petryk A, et al. Vitamin D deficiency in children and its management:review of current knowledge and recommendations. Pediatrics. 2008;122:398–17.CrossRefPubMed
3.
Ross AC. Dietary reference intakes for calcium and vitamin D and calcium. Institute of Medicine. Washington, DC: The National Academies Press; 2011.
4.
5.
Klingberg E, Oleröd G, Konar J, Petzold M, Hammarsten O. Seasonal variations in serum 25-hydroxy vitamin D levels in Swedish cohort. Endocrine. 2015;49:800–8.CrossRefPubMedPubMedCentral
6.
Bozkurt S, Alkan BM, Yıldız F, et al. Age, sex, and seasonal variations in the serum vitamin D3 levels in a local Turkish population. Arch Rheumatol. 2014;29:14–9.CrossRef
7.
Darling AL, Hart KH, Gibbs MA, et al. Greater seasonal cycling of 25-hydroxyvitamin D is associated with increased parathyroid hormone and bone resorption. Osteoporos Int. 2014;25:933–41.CrossRefPubMed
8.
Vuistiner P, Rousson V, Henry H, et al. A population- based model to consider the effect of seasonal variation of serum 25(OH)D and vitamin D status. Biomed Res Int. 2015 (cited 2016 Jan 28;2015:168–89.CrossRef
9.
Kroll MH, Bi C, Garber CC, et al. Temporal relationship between vitamin D status and parathyroid hormone in the United States. PLoS One. 2015 (cited 2016 Jan 28;10:e0118108.CrossRefPubMedPubMedCentral
10.
EnkoD FL, Rezanka E, Stolba R, Ernst J, Wenler I, Fabian D, Hauptlorenz S, Halwachs-Baumann G. 25-hydroxy-vitamin D status:limitations in comparison and clinical interpretation of serum-levels across different assay methods. Clin Lab. 2014;60:1541–50.
11.
Janssen MJW, Wielders JPM, Bekker CC, Besten LSM, Buijs MM, Heijboer AC, van der Horst FAL, Loupatty FJ, van den Ouweland JMW. Multicenter comparison study of current methods to measure 25-hydroxyvitamin D in serum. Steroids. 2012(cited 2016 Jan 28;77:1366–72.CrossRefPubMed
12.
Malbanan A, Veronikis IE, Holick MF. Redifinig vitamin D insufficincy. Lancet. 1998 (cited 2016 Jan 28;351:805–6.CrossRef
13.
Kavakiotis I, Tsave O, Salifoglou A, Maglaveras N, Vlahavas I, Chouvarda I. Machine learning and data mining methods in diabetes research. Comput Struct Biotechnol J. 2017;15:104–16.CrossRefPubMedPubMedCentral
14.
Martin-Sanchez FJ, Aguiar-Pulido V, Lopez-Campos GH, Peek N, Sacchi L. Secondary use and analysis of big data collected for patient care. Yearb Med Inform. 2017;26:28–37.CrossRefPubMed
15.
Looker AC, Dawson-Hughes B, Calvo MS, Gunther EW, et al. Serum 25-hydroxy vitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone. 2002;30:771–7.CrossRefPubMed
16.
El-Hajj FG. Vitamin D deficiency pandemic and consequences for non-skeletal health:mechanisms of action. Mol Asp Med. 2008;29:361–8.CrossRef
17.
Mithal A, Wahl DA, Bonjour JP, Burckhardt P, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporosis. 2009;20:1807–20.CrossRef
18.
Arabi A, El Rassi R, El-Hajj G. Hypovitaminosos D in developing countries-prevalence, risk factors and outcomes. Nat Rev Endocrinol Metab. 2011;25:671–80.
19.
Wahl DA, Cooper C, Ebeling PR, et al. A global representation of vitamin D status in healthy populations. Arch Ost. 2012;7:155–72.CrossRef
20.
Karagüzel D, Dilber B, Çan G, et al. Seasonal vitamin D status of healthy schoolchildren and predictors of low vitamin D status. J Pediatr Gastrenterol Nutr. 2014;58:654–60.CrossRef
21.
Vierucci F, Del Pistoia M, Fanos M, et al. Vitamin D status and predictors of hypovitaminosis D in Italian children and adolescents: a cross sectional study. Eur J Pediatr. 2013;172:1607–17.CrossRefPubMed
22.
Weng FL, Shults J, Leonard MB, et al. Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents. Am J Clin Nutr. 2007;86:150–8.CrossRefPubMed
23.
Rovner AJ, O’Brien KO. Hypovitaminosis D among healthy children in the United States: a review of the current evidence. Arch Ped Adoles Med. 2008;162:513–9.CrossRef
24.
Sullivan SS, Rosen CJ, Halteman WA, et al. Adolescent girls in Maine are at risk for vitamin D insufficiency. J American Diet Assoc. 2005;105:971–4.CrossRef
25.
Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int. 1997;7:439–43.CrossRefPubMed
26.
Atapattu N, Shaw N, Högler W. Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the search for a biochemical definition of vitamin D deficiency in children. Pediatr Res. 2016;74:552–6.CrossRef
27.
Saliba W, Barnett O, Rennert HS, Lavi I, Rennert G. The relationship between serum 25(OH)D and parathyroid hormone levels. Am J Med. 2016;124:1165–70.CrossRef
28.
Abrams SA, Griffin IJ, Hawthorne KM, Gunn SK, Gundberg CM, Carpenter TO. Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents. J Clin Endocrinol Metab. 2005;90:5576–81.CrossRefPubMedPubMedCentral
29.
Adami S, Viapiana O, Gatti D, et al. Relationship between serum parathyroid hormone, vitamin D sufficiency, age and calcium intake. Bone. 2016;42:267–70.CrossRef
30.
Serdar MA, Can BB, Kilercik M, Durer ZA, Aksungar FB, Serteser M, Coskun A, Ozpinar A, Unsal I. Analysis of changes in parathyroid hormone and 25(OH) vitamin D levels with respect to age, gender and season: a data mining study. J Med Biochem. 2017;36:73–83.CrossRefPubMedPubMedCentral
31.
Abrams SA, Griffin IJ, Hawthorne KM, et al. Relationships among vitamin D levels, parathyroid hormone, and calcium absorbtion in young adolescents. J Clin Endocrinol and Metab. 2005;90:5576–81.CrossRef
32.
Saliba W, Barnett O, Rennert H, et al. The relationship between serum 25(OH)Dand parathyroid hormone in normal and osteoporotic postmenopausal women. J Clin Endocrinol and Metab. 1989;69:1024–7.CrossRef
33.
Hill KM, McCabe LD, Gordon CM, Abrams SA, Weaver CM. An inflection point of serum 25-hydroxyvitamin D for maximal suppression of parathyroid hormone is not evident from muti-site pooled data in children and adolescents. J Nutr. 2010;140:1983–8.CrossRefPubMedPubMedCentral
34.
Tsai KS, Ebeling PR, Riggs BL. Bone responsiveness to PTH hormone in normal and osteoporotic postmenopausal women. J Clin Endocrinol and Metab. 1989;69:1024–7.CrossRef
35.
Shivane VK, Sarathi V, Bandgar T, et al. High prevalence of hypovitaminosis D in young healthy adults from the western part of India. Post Med J. 2011;87:514–8.CrossRef
36.
Berger C, Greene-Finestone LS, Langsetmo L, et al. Temporal trends and determinants of longitudinal change in 25-hydroxyvitamin D and parathyroid hormone levels. J B Min Res. 2012;27:1381–9.CrossRef
37.
Ginde AA, Wolfe P, Camargo CA, et al. RS. Defining vitamin D status by secondary hyperparathyroidism in the U.S population. J Endocrinol Investig. 2012;35:42–8.
38.
Palermo NE, Holick MF. Vitamin D, bone helath, and other health benefits in pediatric patients. J Ped Rehab Med. 2014;7:179–92.
Metadata
Title
Vitamin D levels and parathyroid hormone variations of children living in a subtropical climate: a data mining study
Authors
Ozlem Naciye Sahin
Muhittin Serdar
Mustafa Serteser
Ibrahim Unsal
Aysel Ozpinar
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2018
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-018-0479-8

Other articles of this Issue 1/2018

Italian Journal of Pediatrics 1/2018 Go to the issue

Review

Food triggers and inherited metabolic disorders: a challenge to the pediatrician

Review

SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children

Case report

Favorable course of previously undiagnosed Methylmalonic Aciduria with Homocystinuria (cblC type) presenting with pulmonary hypertension and aHUS in a young child: a case report

Research

Dolutegravir-based anti-retroviral therapy is effective and safe in HIV–infected paediatric patients

Commentary

Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at diagnosis

Research

A comparison of efficacy of six prediction models for intravenous immunoglobulin resistance in Kawasaki disease