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Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2016

Open Access 01-12-2016 | Research

Intussusception hospitalizations incidence in the pediatric population in Italy: a nationwide cross-sectional study

Authors: Francesco Trotta, Roberto Da Cas, Antonino Bella, Carmela Santuccio, Stefania Salmaso

Published in: Italian Journal of Pediatrics | Issue 1/2016

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Abstract

Background

Study to investigate the intussusception incidence background in the pediatric population and its temporal trend in Italy.

Methods

A cross-sectional study was conducted on the pediatric population aged 0 to 15 years, in the period 1 January 2002 to 31 December 2012. Intussusception cases were identified using the national hospital discharge database. The annual intussusception incidence, the incidence rate ratios (IRRs) and the related 95 % confidence Intervals (CI) were calculated.

Results

The overall intussusception incidence rate was 21 per 100,000 children aged ≤15 years, and was higher among boys than girls. The highest intussusception incidence rate occurred in infants <1 year of age (39 per 100,000 infants). Among infants, incidence varied with the geographical area, with higher rates in the central Italy (50 per 100,000 infants).
The annual incidence rates in infants were stable since 2004 and up to 2012, ranging from 40.1 and 33.0 per 100,000 infants. Similar stable patterns were observed when conducting the analysis on children over 1 year of age.

Conclusions

This study provided the intussusception incidence background in Italy in different pediatric ages, including infants, over an 11-year period. This information is essential in post-marketing safety surveillance, to continuously monitor the benefit/risk profile of rotavirus vaccinations.
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Metadata
Title
Intussusception hospitalizations incidence in the pediatric population in Italy: a nationwide cross-sectional study
Authors
Francesco Trotta
Roberto Da Cas
Antonino Bella
Carmela Santuccio
Stefania Salmaso
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2016
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-016-0298-8

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