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Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2016

Open Access 01-12-2016 | Research

Meta-analysis of diagnostic accuracy of neutrophil CD64 for neonatal sepsis

Authors: Jing Shi, Jun Tang, Dapeng Chen

Published in: Italian Journal of Pediatrics | Issue 1/2016

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Abstracts

Background

The aim of this study was to systematically evaluate the diagnostic performance of nCD64 for neonatal sepsis.

Methods

Computer retrieval was conducted for the databases of PubMed, Embase, and Springer databases up to March 18, 2015 to select the relevant studies on nCD64 and neonatal sepsis. Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and 95 % confidence intervals (CI) for diagnostic efficiency of nCD64 were pooled. In addition, the summary receiver operating characteristic (SROC) curve was also conducted based on the sensitivity and specificity.

Results

Seventeen studies including 3478 participants were included in this meta-analysis. The overall pooled sensitivity, specificity, PLR, NLR and DOR were 0.77 (95 % CI: 0.74–0.79), 0.74 (95 % CI: 0.72–0.75), 3.58 (95 % CI: 2.85–4.49), 0.29 (95 % CI: 0.22–0.37) and 15.18 (95 % CI: 9.75–23.62), respectively. In addition, the area under the SROC curve (AUC) was 0.8666, and no threshold effect was found based on the Spearman correlation analysis (P = 0.616). Besides, subgroup analysis showed higher sensitivity, specificity and AUC in term infants and proven infection group than those in preterm infants and clinical infection group, respectively.

Conclusions

The n CD64 expression alone is not a satisfactory marker for diagnosing neonatal sepsis with relatively low sensitivity, specificity, PLR and NLR, in spite of relatively high SROC area. Therefore, the n CD64 expression used in diagnosis of neonatal sepsis should be treated with caution.
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Metadata
Title
Meta-analysis of diagnostic accuracy of neutrophil CD64 for neonatal sepsis
Authors
Jing Shi
Jun Tang
Dapeng Chen
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2016
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-016-0268-1

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