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Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 1/2017

Open Access 01-12-2017 | Original research

Mortality due to traumatic spinal cord injuries in Europe: a cross-sectional and pooled analysis of population-wide data from 22 countries

Authors: Marek Majdan, Dominika Plancikova, Eva Nemcovska, Lenka Krajcovicova, Alexandra Brazinova, Martin Rusnak

Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | Issue 1/2017

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Abstract

Background

Traumatic spinal cord injuries (TSCI) pose a significant burden globally, while existing epidemiological data–especially on population mortality–are limited. The aim of this study was to calculate the age-standardized population mortality rates attributable to TSCI in 22 European countries, along with the pooled age-standardized mortality rate attributable to TSCI in Europe.

Methods

A descriptive cross-sectional epidemiological study was conducted. Crude and age-standardized mortality rates attributable to TSCI for the year 2012 for 22 European countries were compared using data from death certificates provided by Eurostat. Pooled age-standardized mortality rates were calculated using the random effects model, and overall number of cases were estimated by extrapolating our findings to the populations of EU and Europe (48 countries), in 2012.

Results

A total of 1840 TSCI-related deaths were identified, of which 1084 (59%) were males. The pooled age-standardized TSCI-related mortality rate of 6.7 per million (95% CI: 5.2 to 8.2) overall, 9.4 (95% CI: 7.3 to 11.5) for males, and 4.5 (95% CI: 3.4 to 5.6) for females. Extrapolating our results, 3152 (95% CI: 2441 to 3915) deaths would occur in 2012 in the EU-28 and 4570 (95% CI: 3538 to 5675) deaths in the whole Europe. TSCI-related deaths contributed by 2% (95% CI: 1.8% to 2.2%) to the overall injury related mortality. 61% of fatal TSCI were located in the cervical spine area.

Conclusion

To our knowledge, this is the largest study that reports TSCI-related population-based mortalities to date which brings valuable information that can inform further research or prevention strategies. Our study presents a comprehensive and large-scale overview of TSCI-related population mortality in Europe. With an estimated toll of nearly five thousand lives that could be potentially saved by prevention, our findings confirm TSCI as an important cause of injury related deaths in Europe. Further action towards harmonization of case ascertainment and towards prevention strategies targeted mainly on the elderly is warranted.
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Literature
1.
go back to reference WHO. In: Bickenbach J, Bodine C, Brown D, Burns A, Campbell R, Cardenas D, Charlifue S, Chen Y, Gray D, Li L, et al., editors. International perspectives on spinal cord injury. Geneva, WHO; 2013. WHO. In: Bickenbach J, Bodine C, Brown D, Burns A, Campbell R, Cardenas D, Charlifue S, Chen Y, Gray D, Li L, et al., editors. International perspectives on spinal cord injury. Geneva, WHO; 2013.
2.
go back to reference Polinder S, Meerding WJ, Mulder S, Petridou E, van Beeck E, Group ER. Assessing the burden of injury in six European countries. Bull World Health Organ. 2007;85(1):27–34.CrossRefPubMedPubMedCentral Polinder S, Meerding WJ, Mulder S, Petridou E, van Beeck E, Group ER. Assessing the burden of injury in six European countries. Bull World Health Organ. 2007;85(1):27–34.CrossRefPubMedPubMedCentral
3.
go back to reference Lee BB, Cripps RA, Fitzharris M, Wing PC. The global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate. Spinal Cord. 2014;52(2):110–6.CrossRefPubMed Lee BB, Cripps RA, Fitzharris M, Wing PC. The global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate. Spinal Cord. 2014;52(2):110–6.CrossRefPubMed
4.
go back to reference Devivo MJ. Epidemiology of traumatic spinal cord injury: trends and future implications. Spinal Cord. 2012;50(5):365–72.CrossRefPubMed Devivo MJ. Epidemiology of traumatic spinal cord injury: trends and future implications. Spinal Cord. 2012;50(5):365–72.CrossRefPubMed
5.
go back to reference van den Berg ME, Castellote JM, Mahillo-Fernandez I, de Pedro-Cuesta J. Incidence of spinal cord injury worldwide: a systematic review. Neuroepidemiology. 2010;34(3):184–92. discussion 192CrossRefPubMed van den Berg ME, Castellote JM, Mahillo-Fernandez I, de Pedro-Cuesta J. Incidence of spinal cord injury worldwide: a systematic review. Neuroepidemiology. 2010;34(3):184–92. discussion 192CrossRefPubMed
6.
go back to reference Chiu WT, Lin HC, Lam C, Chu SF, Chiang YH, Tsai SH. Review paper: epidemiology of traumatic spinal cord injury: comparisons between developed and developing countries. Asia Pac J Public Health. 2010;22(1):9–18.CrossRefPubMed Chiu WT, Lin HC, Lam C, Chu SF, Chiang YH, Tsai SH. Review paper: epidemiology of traumatic spinal cord injury: comparisons between developed and developing countries. Asia Pac J Public Health. 2010;22(1):9–18.CrossRefPubMed
7.
go back to reference Ackery A, Tator C, Krassioukov A. A global perspective on spinal cord injury epidemiology. J Neurotrauma. 2004;21(10):1355–70.CrossRefPubMed Ackery A, Tator C, Krassioukov A. A global perspective on spinal cord injury epidemiology. J Neurotrauma. 2004;21(10):1355–70.CrossRefPubMed
8.
go back to reference Cripps RA, Lee BB, Wing P, Weerts E, Mackay J, Brown D. A global map for traumatic spinal cord injury epidemiology: towards a living data repository for injury prevention. Spinal Cord. 2011;49(4):493–501.CrossRefPubMed Cripps RA, Lee BB, Wing P, Weerts E, Mackay J, Brown D. A global map for traumatic spinal cord injury epidemiology: towards a living data repository for injury prevention. Spinal Cord. 2011;49(4):493–501.CrossRefPubMed
9.
go back to reference Wyndaele M, Wyndaele JJ. Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey? Spinal Cord. 2006;44(9):523–9.CrossRefPubMed Wyndaele M, Wyndaele JJ. Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey? Spinal Cord. 2006;44(9):523–9.CrossRefPubMed
10.
go back to reference Rubiano AM, Carney N, Chesnut R, Puyana JC. Global neurotrauma research challenges and opportunities. Nature. 2015;527(7578):S193–7.CrossRefPubMed Rubiano AM, Carney N, Chesnut R, Puyana JC. Global neurotrauma research challenges and opportunities. Nature. 2015;527(7578):S193–7.CrossRefPubMed
14.
go back to reference Commison E. In: Commison E, editor. Commission regulation (EU) no 328/2011 of 5 April 2011 implementing regulation (EC) no 1338/2008 of the European Parliament and of the council on community statistics on public health and health and safety at work, as regards statistics on causes of death. European Commison: Brussels; 2011. Commison E. In: Commison E, editor. Commission regulation (EU) no 328/2011 of 5 April 2011 implementing regulation (EC) no 1338/2008 of the European Parliament and of the council on community statistics on public health and health and safety at work, as regards statistics on causes of death. European Commison: Brussels; 2011.
15.
go back to reference Eurostat. Revision of the European standard population, report of Eurostat’s task force. Luxembourg: Eurostat; 2013. Eurostat. Revision of the European standard population, report of Eurostat’s task force. Luxembourg: Eurostat; 2013.
16.
go back to reference Division DESAP. World population prospects the 2015 revision key findings and advance tables. In: Working Paper No ESA/P/WP241. New York: United Nations; 2015. Division DESAP. World population prospects the 2015 revision key findings and advance tables. In: Working Paper No ESA/P/WP241. New York: United Nations; 2015.
17.
go back to reference R-Core-Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing: Vienna, Austria; 2014. R-Core-Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing: Vienna, Austria; 2014.
18.
go back to reference Saunders LL, Selassie AW, Hill EG, Nicholas JS, Varma AK, Lackland DT, Patel SJ. Traumatic spinal cord injury mortality, 1981-1998. J Trauma. 2009;66(1):184–90.CrossRefPubMed Saunders LL, Selassie AW, Hill EG, Nicholas JS, Varma AK, Lackland DT, Patel SJ. Traumatic spinal cord injury mortality, 1981-1998. J Trauma. 2009;66(1):184–90.CrossRefPubMed
19.
go back to reference Majdan M, Brazinova A, Mauritz W. Epidemiology of traumatic spinal cord injuries in Austria 2002-2012. Eur Spine J. 2016;25(1):62–73.CrossRefPubMed Majdan M, Brazinova A, Mauritz W. Epidemiology of traumatic spinal cord injuries in Austria 2002-2012. Eur Spine J. 2016;25(1):62–73.CrossRefPubMed
20.
go back to reference Lidal IB, Snekkevik H, Aamodt G, Hjeltnes N, Biering-Sorensen F, Stanghelle JK. Mortality after spinal cord injury in Norway. J Rehabil Med. 2007;39(2):145–51.CrossRefPubMed Lidal IB, Snekkevik H, Aamodt G, Hjeltnes N, Biering-Sorensen F, Stanghelle JK. Mortality after spinal cord injury in Norway. J Rehabil Med. 2007;39(2):145–51.CrossRefPubMed
21.
go back to reference Sabre L, Rekand T, Asser T, Korv J. Mortality and causes of death after traumatic spinal cord injury in Estonia. J Spinal Cord Med. 2013;36(6):687–94.CrossRefPubMedPubMedCentral Sabre L, Rekand T, Asser T, Korv J. Mortality and causes of death after traumatic spinal cord injury in Estonia. J Spinal Cord Med. 2013;36(6):687–94.CrossRefPubMedPubMedCentral
22.
go back to reference Soden RJ, Walsh J, Middleton JW, Craven ML, Rutkowski SB, Yeo JD. Causes of death after spinal cord injury. Spinal Cord. 2000;38(10):604–10.CrossRefPubMed Soden RJ, Walsh J, Middleton JW, Craven ML, Rutkowski SB, Yeo JD. Causes of death after spinal cord injury. Spinal Cord. 2000;38(10):604–10.CrossRefPubMed
23.
go back to reference Chamberlain JD, Meier S, Mader L, von Groote PM, Brinkhof MW. Mortality and longevity after a spinal cord injury: systematic review and meta-analysis. Neuroepidemiology. 2015;44(3):182–98.CrossRefPubMed Chamberlain JD, Meier S, Mader L, von Groote PM, Brinkhof MW. Mortality and longevity after a spinal cord injury: systematic review and meta-analysis. Neuroepidemiology. 2015;44(3):182–98.CrossRefPubMed
24.
go back to reference Pickett GE, Campos-Benitez M, Keller JL, Duggal N. Epidemiology of traumatic spinal cord injury in Canada. Spine (Phila Pa 1976). 2006;31(7):799–805.CrossRef Pickett GE, Campos-Benitez M, Keller JL, Duggal N. Epidemiology of traumatic spinal cord injury in Canada. Spine (Phila Pa 1976). 2006;31(7):799–805.CrossRef
25.
go back to reference DeVivo MJ, Krause JS, Lammertse DP. Recent trends in mortality and causes of death among persons with spinal cord injury. Arch Phys Med Rehabil. 1999;80(11):1411–9.CrossRefPubMed DeVivo MJ, Krause JS, Lammertse DP. Recent trends in mortality and causes of death among persons with spinal cord injury. Arch Phys Med Rehabil. 1999;80(11):1411–9.CrossRefPubMed
26.
go back to reference Hagen EM, Lie SA, Rekand T, Gilhus NE, Gronning M. Mortality after traumatic spinal cord injury: 50 years of follow-up. J Neurol Neurosurg Psychiatry. 2010;81(4):368–73.CrossRefPubMed Hagen EM, Lie SA, Rekand T, Gilhus NE, Gronning M. Mortality after traumatic spinal cord injury: 50 years of follow-up. J Neurol Neurosurg Psychiatry. 2010;81(4):368–73.CrossRefPubMed
27.
go back to reference Strauss DJ, Devivo MJ, Paculdo DR, Shavelle RM. Trends in life expectancy after spinal cord injury. Arch Phys Med Rehabil. 2006;87(8):1079–85.CrossRefPubMed Strauss DJ, Devivo MJ, Paculdo DR, Shavelle RM. Trends in life expectancy after spinal cord injury. Arch Phys Med Rehabil. 2006;87(8):1079–85.CrossRefPubMed
28.
go back to reference Hagen EM, Rekand T, Gilhus NE, Gronning M. Diagnostic coding accuracy for traumatic spinal cord injuries. Spinal Cord. 2009;47(5):367–71.CrossRefPubMed Hagen EM, Rekand T, Gilhus NE, Gronning M. Diagnostic coding accuracy for traumatic spinal cord injuries. Spinal Cord. 2009;47(5):367–71.CrossRefPubMed
Metadata
Title
Mortality due to traumatic spinal cord injuries in Europe: a cross-sectional and pooled analysis of population-wide data from 22 countries
Authors
Marek Majdan
Dominika Plancikova
Eva Nemcovska
Lenka Krajcovicova
Alexandra Brazinova
Martin Rusnak
Publication date
01-12-2017
Publisher
BioMed Central
DOI
https://doi.org/10.1186/s13049-017-0410-0

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