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Open Access 01-12-2019 | Ovarian Cancer | Research

LncRNA AB209371 up-regulated Survivin gene by down-regulating miR-203 in ovarian carcinoma

Authors: Zi-Hui Zheng, Dong-Mei Wu, Shao-Hua Fan, Xin Wen, Xin-Rui Han, Shan Wang, Yong-Jian Wang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Yuan-Lin Zheng, Jun Lu

Published in: Journal of Ovarian Research | Issue 1/2019

Abstract

AB209371 gene has been characterized as an oncogenic lncRNA in liver cancer. However, its involvement in ovarian carcinoma (OC) is unknown. In the present study, we analyzed the roles of AB209371 in OC. We found that AB209371 gene and Survivin gene were up-regulated in OC and positively correlated with OC development. AB209371 over-expression led to up-regulated Survivin in OC cells, while Survivin over-expression failed to affect AB209371. In addition, AB209371 over-expression led to down-regulated miR-203. However, miR-203 over-expression failed to affect AB209371, but down-regulated the expression of Survivin. In addition, over-expressions of AB209371 and Survivin resulted in the increased proliferation rate of OC cells. Over-expression MiR-203 played the opposite role and attenuated the effects of AB209371 over-expression. Therefore, AB209371 may down-regulate miR-203 to up-regulate Survivin, thereby promoting OC cell proliferation. Our study provided novel insights into the pathogenesis of OC.

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Title: LncRNA AB209371 up-regulated Survivin gene by down-regulating miR-203 in ovarian carcinoma
Authors: Zi-Hui Zheng
Dong-Mei Wu
Shao-Hua Fan
Xin Wen
Xin-Rui Han
Shan Wang
Yong-Jian Wang
Zi-Feng Zhang
Qun Shan
Meng-Qiu Li
Bin Hu
Yuan-Lin Zheng
Jun Lu
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Ovarian Cancer
Ovarian Cancer
Published in: Journal of Ovarian Research / Issue 1/2019
Electronic ISSN: 1757-2215
DOI: https://doi.org/10.1186/s13048-019-0559-4

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LncRNA AB209371 up-regulated Survivin gene by down-regulating miR-203 in ovarian carcinoma

Abstract

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Abstract

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