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Open Access 01-12-2018 | Review

The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention

Authors: Hui Guo, Jing Guo, Wenli Xie, Lingqin Yuan, Xiugui Sheng

Published in: Journal of Ovarian Research | Issue 1/2018

Abstract

Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention by regulating cellular proliferation and metabolism. Studies of the cellular mechanism of vitamin D in ovarian cancer strongly suggest that it exhibits protective and antitumorigenic activities through genomic and nongenomic signal transduction pathways. These results indicate that vitamin D deficiency results in an increase in the risk of developing ovarian cancer and that vitamin supplements may potentially be an efficient way of preventing cancer. Consequently, this review describes the epidemiology, molecular mechanism and evidence linking vitamin D deficiency to ovarian cancer.

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Title: The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention
Authors: Hui Guo
Jing Guo
Wenli Xie
Lingqin Yuan
Xiugui Sheng
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Journal of Ovarian Research / Issue 1/2018
Electronic ISSN: 1757-2215
DOI: https://doi.org/10.1186/s13048-018-0443-7

ACC 2024 Congress

Springer Medicine

The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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