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Journal of Ovarian Research
Published in: Journal of Ovarian Research 1/2017

Open Access 01-12-2017 | Review

Racial health disparities in ovarian cancer: not just black and white

Authors: Sanjeev K. Srivastava, Aamir Ahmad, Orlandric Miree, Girijesh Kumar Patel, Seema Singh, Rodney P. Rocconi, Ajay P. Singh

Published in: Journal of Ovarian Research | Issue 1/2017

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Abstract

Ovarian cancer (OC) is the most lethal gynecological malignancy, which disproportionately affects African American (AA) women. Lack of awareness and socioeconomic factors are considered important players in OC racial health disparity, while at the same time, some recent studies have brought focus on the genetic basis of disparity as well. Differential polymorphisms, mutations and expressions of genes have been reported in OC patients of diverse racial and ethnic backgrounds. Combined, it appears that neither genetic nor the socioeconomic factors alone might explain the observed racially disparate health outcomes among OC patients. Rather, a more logical explanation would be the one that takes into consideration the combination and/or the interplay of these factors, perhaps even including some environmental ones. Hence, in this article, we attempt to review the available information on OC racial health disparity, and provide an overview of socioeconomic, environmental and genetic factors, as well as the epigenetic changes that can act as a liaison between the three. A better understanding of these underlying causes will help further research on effective cancer management among diverse patient population and ultimately narrow health disparity gaps.
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Metadata
Title
Racial health disparities in ovarian cancer: not just black and white
Authors
Sanjeev K. Srivastava
Aamir Ahmad
Orlandric Miree
Girijesh Kumar Patel
Seema Singh
Rodney P. Rocconi
Ajay P. Singh
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Ovarian Research / Issue 1/2017
Electronic ISSN: 1757-2215
DOI
https://doi.org/10.1186/s13048-017-0355-y

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