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Journal of Ovarian Research
Published in: Journal of Ovarian Research 1/2016

Open Access 01-12-2016 | Research

Preoperative HE4, CA125 and ROMA in the differential diagnosis of benign and malignant adnexal masses

Authors: Katarzyna M. Terlikowska, Bozena Dobrzycka, Anna M. Witkowska, Beata Mackowiak-Matejczyk, Tomasz Kamil Sledziewski, Maciej Kinalski, Slawomir J. Terlikowski

Published in: Journal of Ovarian Research | Issue 1/2016

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Abstract

Background

The aim of this study was to evaluate HE4, CA125 and ROMA in the preoperative differentiation benign ovarian diseases from epithelial ovarian cancer depending on the menopausal status.

Methods

In order to estimate markers’ concentrations in the serum of women with benign ovarian disease (n = 128) and with epithelial ovarian carcinoma (n = 96) the electrochemiluminescence (ECLIA) technique has been applied.

Results

Using the ROC analysis, although no statistical differences were found among their AUCs, the ROMA algorithm seems to be effective in gathering the diverse performance of HE4 and CA125. The AUC for HE4, CA125 and ROMA for all patients were: 0.895; 0.879 and 0.918, respectively. At established new optimal cutoff values for HE4, CA125 and ROMA we found higher specificity in postmenopausal compared to premenopausal women (96.9 vs 89.8 % and 97.7 vs 84.1 % and 95.9 vs 89.1 %, respectively). The sensitivity of HE4 in pre- and postmenopausal women was similar (83.5 vs 83.8 %), while for CA125 was the highest in premenopausal women (87.0 vs 84.1 %). For HE4, CA125 and ROMA the negative predictive value was high (97.6, 93.9 and 94.4 %, respectively).

Conclusions

The ROMA algorithm shows the best diagnostic performance to distinguish epithelial ovarian cancer from benign ovarian disease. We found the high specificity of HE4 and CA125 while differentiating ovarian benign diseases from epithelial ovarian cancer in postmenopausal women and the high sensitivity of CA125 in detecting epithelial ovarian cancer in premenopausal patients.
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Metadata
Title
Preoperative HE4, CA125 and ROMA in the differential diagnosis of benign and malignant adnexal masses
Authors
Katarzyna M. Terlikowska
Bozena Dobrzycka
Anna M. Witkowska
Beata Mackowiak-Matejczyk
Tomasz Kamil Sledziewski
Maciej Kinalski
Slawomir J. Terlikowski
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Ovarian Research / Issue 1/2016
Electronic ISSN: 1757-2215
DOI
https://doi.org/10.1186/s13048-016-0254-7

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