Skip to main content
Top
Published in: Journal of Ovarian Research 1/2015

Open Access 01-12-2015 | Review

Perspective in infertility: the ovarian stem cells

Authors: Erica Silvestris, Stella D’Oronzo, Paola Cafforio, Giuseppe D’Amato, Giuseppe Loverro

Published in: Journal of Ovarian Research | Issue 1/2015

Login to get access

Abstract

Infertility is a medical and social condition that affects millions of women worldwide and is today considered so far as a new disease. A considerable progress has been recently pursued in the field of the reproductive medicine and the infertility treatment may account for novel and modern procedures such as in vitro oocyte fertilization, egg donation, pregnancy surrogacy and preimplantation diagnosis. However, great interest has lately been reserved to the ovarian stem cells (OSCs) whose existence in woman ovaries has been proven. OSCs are thus suitable for developmental studies in infertility and in other clinical applications as endocrine derangements due to premature ovarian failure, or for infertility treatment after cancer chemotherapies, as well as in restoring the hormonal balance in postmenopausal age.
Literature
1.
go back to reference Nattiv A, Loucks AB, Manore MM, Sanbom CF, Sundgot-Borgen J, Warren MP. American College of Sports Medicine position stand. The female athlete triad. Med Sci Sports Exerc. 2007;39:1867–82.PubMedCrossRef Nattiv A, Loucks AB, Manore MM, Sanbom CF, Sundgot-Borgen J, Warren MP. American College of Sports Medicine position stand. The female athlete triad. Med Sci Sports Exerc. 2007;39:1867–82.PubMedCrossRef
2.
go back to reference Perales-Puchalt A, Legro RS. Ovulation induction in women with polycystic ovary syndrome. Steroids. 2013;78:767–72.PubMedCrossRef Perales-Puchalt A, Legro RS. Ovulation induction in women with polycystic ovary syndrome. Steroids. 2013;78:767–72.PubMedCrossRef
5.
go back to reference Zuckerman S. The number of oocytes in the mature ovary. Rec Prog Horm Res. 1951;6:63–108. Zuckerman S. The number of oocytes in the mature ovary. Rec Prog Horm Res. 1951;6:63–108.
6.
go back to reference Johnson J, Canning J, Kaneko T, Pru JK, Tilly JL. Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature. 2004;428:145–50.PubMedCrossRef Johnson J, Canning J, Kaneko T, Pru JK, Tilly JL. Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature. 2004;428:145–50.PubMedCrossRef
7.
go back to reference Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Mayo KE, Shea LD, et al. Fate of the initial follicle pool: empirical and mathematical evidence supporting its sufficiency for adult fertility. Developmental Biology. 2006;298:149–54.PubMedCrossRef Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Mayo KE, Shea LD, et al. Fate of the initial follicle pool: empirical and mathematical evidence supporting its sufficiency for adult fertility. Developmental Biology. 2006;298:149–54.PubMedCrossRef
8.
go back to reference Johnson J, Bagley J, Skaznik-Wikiel M, Lee H, Adams GB, Niikura Y, et al. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell. 2005;122:303–15.PubMedCrossRef Johnson J, Bagley J, Skaznik-Wikiel M, Lee H, Adams GB, Niikura Y, et al. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell. 2005;122:303–15.PubMedCrossRef
9.
go back to reference Lee HJ, Selesniemi K, Niikura Y, Niikura T, Klein R, Dombkowski DM, et al. Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure. J Clin Oncol. 2007;25:3198–204.PubMedCrossRef Lee HJ, Selesniemi K, Niikura Y, Niikura T, Klein R, Dombkowski DM, et al. Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure. J Clin Oncol. 2007;25:3198–204.PubMedCrossRef
10.
go back to reference Zou K, Yuan Z, Yang Z, Luo H, Sun K, Zhou L, et al. Production of offspring from a germline stem cell line derived from neonatal ovaries. Nature Cell Biology. 2009;11:631–50.PubMedCrossRef Zou K, Yuan Z, Yang Z, Luo H, Sun K, Zhou L, et al. Production of offspring from a germline stem cell line derived from neonatal ovaries. Nature Cell Biology. 2009;11:631–50.PubMedCrossRef
11.
go back to reference Stimpfel M, Skutella T, Cvjeticanin B, Meznaric M, Dovc P, Novakovic P, et al. Isolation, characterization and differentiation of cells expressing pluripotent/multipo-tent markers from adult human ovaries. Cell Tissue Res. 2013;354:593–607.PubMedCrossRef Stimpfel M, Skutella T, Cvjeticanin B, Meznaric M, Dovc P, Novakovic P, et al. Isolation, characterization and differentiation of cells expressing pluripotent/multipo-tent markers from adult human ovaries. Cell Tissue Res. 2013;354:593–607.PubMedCrossRef
12.
go back to reference White YA, Woods DC, Takai Y, Ishihara O, Seki H, Tilly JL. Oocyte formation by mitotically active germ cells purified from ovaries of reproductive age women. Nat Med. 2012;18:413–21.PubMedCentralPubMedCrossRef White YA, Woods DC, Takai Y, Ishihara O, Seki H, Tilly JL. Oocyte formation by mitotically active germ cells purified from ovaries of reproductive age women. Nat Med. 2012;18:413–21.PubMedCentralPubMedCrossRef
13.
go back to reference Dunlop CE, Telfer EE, Anderson RA. Ovarian stem cells. Potential roles in infertility treatment and fertility preservation. Maturitas. 2013;76:279–83.PubMedCrossRef Dunlop CE, Telfer EE, Anderson RA. Ovarian stem cells. Potential roles in infertility treatment and fertility preservation. Maturitas. 2013;76:279–83.PubMedCrossRef
14.
go back to reference Zhang H, Zheng W, Shen Y, Adhikari D, Ueno H, Liu K. Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries. PNAS USA. 2012;109:12580–5.PubMedCentralPubMedCrossRef Zhang H, Zheng W, Shen Y, Adhikari D, Ueno H, Liu K. Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries. PNAS USA. 2012;109:12580–5.PubMedCentralPubMedCrossRef
15.
go back to reference Bhartiya D, Sriraman K, Parte S, Patel H. Ovarian stem cells: absence of evidence is not evidence of absence. J Ovarian Res. 2013;6:1–6.CrossRef Bhartiya D, Sriraman K, Parte S, Patel H. Ovarian stem cells: absence of evidence is not evidence of absence. J Ovarian Res. 2013;6:1–6.CrossRef
16.
go back to reference Parte S, Bhartiya D, Patel H, Daithankar V, Chauhan A, Zaveri K, et al. Dynamics associated with spontaneous differentiation of ovarian stem cells in vitro. J Ovarian Res. 2014;7:25.PubMedCentralPubMedCrossRef Parte S, Bhartiya D, Patel H, Daithankar V, Chauhan A, Zaveri K, et al. Dynamics associated with spontaneous differentiation of ovarian stem cells in vitro. J Ovarian Res. 2014;7:25.PubMedCentralPubMedCrossRef
17.
go back to reference Zou K, Hou L, Sun K, Xie W, Wu J. Improved efficiency of female germline stem cell purification using fragilis-based magnetic bead sorting. Stem Cells Dev. 2011;20:2197–204.PubMedCrossRef Zou K, Hou L, Sun K, Xie W, Wu J. Improved efficiency of female germline stem cell purification using fragilis-based magnetic bead sorting. Stem Cells Dev. 2011;20:2197–204.PubMedCrossRef
18.
go back to reference Woods DC, Tilly JL. Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries. Nature Prot. 2013;8:966–88.CrossRef Woods DC, Tilly JL. Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries. Nature Prot. 2013;8:966–88.CrossRef
19.
go back to reference Hayashi K, Ogushi S, Kurimoto K, Shimamoto S, Ohta H, Saitou M. Offspring from oocytes derived from in vitro primordial germ cell–like cells in mice. Science. 2012;338:971–5.PubMedCrossRef Hayashi K, Ogushi S, Kurimoto K, Shimamoto S, Ohta H, Saitou M. Offspring from oocytes derived from in vitro primordial germ cell–like cells in mice. Science. 2012;338:971–5.PubMedCrossRef
20.
go back to reference Stimpfel M, Skutella T, Cvjeticanin B, Meznaric M, Dovc P, Novakovic S, et al. Isolation, characterization and differentiation of cells expressing pluripotent/multipotent markers from adult human ovaries. Cell Tissue Res. 2013;354:593–607.PubMedCrossRef Stimpfel M, Skutella T, Cvjeticanin B, Meznaric M, Dovc P, Novakovic S, et al. Isolation, characterization and differentiation of cells expressing pluripotent/multipotent markers from adult human ovaries. Cell Tissue Res. 2013;354:593–607.PubMedCrossRef
22.
go back to reference Woods DC, Tilly JL. The next (re)generation of ovarian biology and fertility in women: is current science tomorrow’s practice? Fertil Steril. 2012;98:3–10.PubMedCentralPubMedCrossRef Woods DC, Tilly JL. The next (re)generation of ovarian biology and fertility in women: is current science tomorrow’s practice? Fertil Steril. 2012;98:3–10.PubMedCentralPubMedCrossRef
23.
go back to reference Virant-Klun I, Zech N, Rozman P, Vogler A, Cvjeticanin B, Klemenc P, et al. Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes. Differentiation. 2008;76:843–56.PubMedCrossRef Virant-Klun I, Zech N, Rozman P, Vogler A, Cvjeticanin B, Klemenc P, et al. Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes. Differentiation. 2008;76:843–56.PubMedCrossRef
24.
go back to reference Lei L, Spradling AC. Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles. PNAS USA. 2013;110:8585–90.PubMedCentralPubMedCrossRef Lei L, Spradling AC. Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles. PNAS USA. 2013;110:8585–90.PubMedCentralPubMedCrossRef
25.
go back to reference Tilly JL, Telfer EE. Purification of germline stem cells from adult mammalian ovaries: a step closer towards control of the female biological clock? Molecular Human Reprod. 2009;15:393–8.CrossRef Tilly JL, Telfer EE. Purification of germline stem cells from adult mammalian ovaries: a step closer towards control of the female biological clock? Molecular Human Reprod. 2009;15:393–8.CrossRef
26.
go back to reference Parrott JA, Kima G, Skinner MK. Expression and action of kit ligand/stem cell factor in normal human and bovine ovarian surface epithelium and ovarian cancer. Biol Reprod. 2000;62:1600–9.PubMedCrossRef Parrott JA, Kima G, Skinner MK. Expression and action of kit ligand/stem cell factor in normal human and bovine ovarian surface epithelium and ovarian cancer. Biol Reprod. 2000;62:1600–9.PubMedCrossRef
27.
go back to reference Woods DC, White YAR, Tilly JL. Purification of oogonial stem cells from adult mouse and human ovaries: an assessment of the literature and a view toward the future. Reproduct Sci. 2013;20:7–15.CrossRef Woods DC, White YAR, Tilly JL. Purification of oogonial stem cells from adult mouse and human ovaries: an assessment of the literature and a view toward the future. Reproduct Sci. 2013;20:7–15.CrossRef
Metadata
Title
Perspective in infertility: the ovarian stem cells
Authors
Erica Silvestris
Stella D’Oronzo
Paola Cafforio
Giuseppe D’Amato
Giuseppe Loverro
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Journal of Ovarian Research / Issue 1/2015
Electronic ISSN: 1757-2215
DOI
https://doi.org/10.1186/s13048-015-0184-9

Other articles of this Issue 1/2015

Journal of Ovarian Research 1/2015 Go to the issue