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Open Access 01-12-2015 | Research

Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas

Authors: Donna Catherine Ferguson, Daniel Jerad Long, Megan Christine Smith, Laura Deeanne Craig-Owens, Julie Means, Oluwole Fadare, Mohamed Mokhtar Desouki

Published in: Journal of Ovarian Research | Issue 1/2015

Abstract

Background

Deregulation of CDK4/6, cyclin D/P16 and retinoblastoma (Rb) are known aberrations in certain malignancies. There has been a recent interest in exploring the combination of letrozole and CDK4/6 inhibitors in recurrent ER+ ovarian cancers.

Methods

This study aimed to determine the frequency of expression of Rb1, P16 and ER in ovarian epithelial tumors by immunohistochemistry.

Results

Co-expression of all 3 markers studied was seen in 10 % of high grade serous carcinoma (HGSC) and low grade serous carcinoma (LGSC). Coordinate expression of Rb1+ and ER+ in HGSC and LGSC was seen in 67 % of grade 1/2 vs. 44 % of grade three tumors (p < 0.05). The reverse was true with positive P16 staining in 73 % of grade three vs. 32 % of grade 1/2 tumors (p < 0.001).

Conclusions

Coordinate pattern of Rb1+ and ER+ in HGSC and LGSC is 19 and 50 %, respectively. Rb1 and P16 show inverse expression pattern according to tumor grade with more frequent Rb1 in low grade vs. more frequent P16 in grade 3 tumors. These data provide a rational basis for clinical trials that aim to target these proteins.

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Title: Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas
Authors: Donna Catherine Ferguson
Daniel Jerad Long
Megan Christine Smith
Laura Deeanne Craig-Owens
Julie Means
Oluwole Fadare
Mohamed Mokhtar Desouki
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Journal of Ovarian Research / Issue 1/2015
Electronic ISSN: 1757-2215
DOI: https://doi.org/10.1186/s13048-015-0163-1

At a glance: The ONWARDS insulin icodec trials

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Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas

Abstract

Background

Methods

Results

Conclusions

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Abstract

Background

Methods

Results

Conclusions

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