Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Journal of Ovarian Research
Published in: Journal of Ovarian Research 1/2014

Open Access 01-12-2014 | Research

Stereotactic radiotherapy in epithelial ovarian cancer brain metastases patients

Authors: Agata Celejewska, Andrzej Tukiendorf, Leszek Miszczyk, Krzysztof Składowski, Jerzy Wydmański, Krystyna Trela-Janus

Published in: Journal of Ovarian Research | Issue 1/2014

Login to get access

Abstract

Background

In this report we present the results of the retrospective (survival and classification) analyses of possible prognostic factors prolonging survival in epithelial ovarian cancer brain metastases patients after stereotactic radiotherapy. We focus on a wide range of available predictors to establish survival in patients with a good health status and no more than three lesions.

Methods

Two parallel statistical methods in survival analysis were used: classical and Bayesian methods to verify statistical results. To display the predicted and posterior survivals, classification trees were built.

Results

From the initial set of prognostic factors, only four were established as statistically significant in multivariate regression. They were: survival to metastases to brain after epithelial ovarian cancer diagnosis, number of metastases at diagnosis, central nervous system radiotherapy prior to stereotactic radiotherapy, and interval to stereotactic radiotherapy after metastases diagnosis.

Conclusions

When considering evidence-based standards of treatment of patients suffering from epithelial ovarian cancer brain metastases, the established clinical factors are suggested to be prognostic.
Appendix
Available only for authorised users
Literature
1.
Mayer RJ, Berkowitz RS, Griffiths CT: Central nervous system involvement by ovarian carcinoma. A complication of prolonged survival with metastatic disease. Cancer 1978, 41: 776–783. 10.1002/1097-0142(197802)41:2<776::AID-CNCR2820410253>3.0.CO;2-ECrossRefPubMed
2.
Cohen ZR, Suki D, Weinberg JS, Marmor E, Lang FF, Gershenson DM, Sawaya R: Brain metastases in patients with ovarian carcinoma: prognostic factors and outcome. J Neuro-Oncol 2005, 66: 313–325. 10.1023/B:NEON.0000014516.04943.38CrossRef
3.
Pectasides D, Aravantinos G, Fountzilas G, Kalofonos C, Efstathiou E, Karina M, Pavlidis N, Farmakis D, Economopoulos T, Dimopoulos MA: Brain metastases from epithelial ovarian cancer. The Hellenic Cooperative Oncology Group (HeCOG) experience and review of the literature. Anticancer Res 2005, 25: 3553–3558.PubMed
4.
Pietzner K, Oskay-Oezcelik G, Khalfaoui K, Boehmer D, Lichtenegger W, Sehouli J: Brain metastases from epithelial ovarian cancer: overview and optimal management. Anticancer Res 2009, 29: 2793–2798.PubMed
5.
Chen YL, Cheng WF, Hsieh CY, Chen CA: Brain metastasis as a late manifestation of ovarian carcinoma. Eur J Cancer Care 2011, 20: 44–49. 10.1111/j.1365-2354.2009.01133.xCrossRef
6.
Hardy JR, Harvey VJ: Cerebral metastases in patients with ovarian cancer treated with chemotherapy. Gynecol Oncol 1989, 33: 296–300. 10.1016/0090-8258(89)90515-5CrossRefPubMed
7.
Bruzzone M, Campora E, Chiara S, Giudici S, Merlini L, Simoni C, Mammoliti S, Rubagotti A, Rosso R: Cerebral metastases secondary to ovarian cancer: still an unusual event. Gynecol Oncol 1993, 49: 37–40. 10.1006/gyno.1993.1082CrossRefPubMed
8.
Chiang YC, Qiu JT, Chang CL, Wang PH, Ho CM, Lin WC, Huang YF, Lin H, Lu CH, Chou CY: Brain metastases from epithelial ovarian carcinoma: evaluation of prognosis and managements – a Taiwanese Gynecol Oncol Group (TGOG) study. Gynecol Oncol 2012, 125: 37–41. 10.1016/j.ygyno.2011.12.438CrossRefPubMed
9.
Micha JP, Goldstein BH, Hunter JV, Rettenmaier MA, Brown JV: Long-term survival in an ovarian cancer patient with brain metastases. Gynecol Oncol 2004, 92: 978–980. 10.1016/j.ygyno.2003.11.024CrossRefPubMed
10.
Pectasides D, Pectasides M, Economopoulos T: Brain metastases from epithelial ovarian cancer: a review of the literature. Oncologist 2006, 11: 252–260. 10.1634/theoncologist.11-3-252CrossRefPubMed
11.
Lee YK, Park NH, Kim JW, Song YS, Kang SB, Lee HP: Gamma-knife radiosurgery as an optimal treatment modality for brain metastases from epithelial ovarian cancer. Gynecol Oncol 2008, 108: 505–509. 10.1016/j.ygyno.2007.11.027CrossRefPubMed
12.
LeRoux PD, Berger MS, Elliott JP, Tamimi HK: Cerebral metastases from ovarian carcinoma. Cancer 1991, 67: 2194–2199. 10.1002/1097-0142(19910415)67:8<2194::AID-CNCR2820670832>3.0.CO;2-#CrossRefPubMed
13.
Cormio G, Maneo A, Parma G, Pittelli MR, Miceli MD, Bonazzi C: Central nervous system metastases in patients with ovarian carcinoma. A report of 23 cases and a literature review. Ann Oncol 1995, 6: 571–574.PubMed
14.
Geisler JP, Geisler HE: Brain metastases in epithelial ovarian carcinoma. Gynecol Oncol 1995, 57: 246–249. 10.1006/gyno.1995.1134CrossRefPubMed
15.
Sood A, Kumar L, Sood R, Sandhu MS: Epithelial ovarian carcinoma metastatic to the central nervous system: a report on two cases with review of literature. Gynecol Oncol 1996, 62: 113–118. 10.1006/gyno.1996.0199CrossRefPubMed
16.
Rodriguez GC, Soper JT, Berchuck A, Oleson J, Dodge R, Montana G, Clarke-Pearson DL: Improved palliation of cerebral metastases in epithelial ovarian cancer using a combined modality approach including radiation therapy, chemotherapy, and surgery. J Clin Oncol 1992, 10: 1553–1560.PubMed
17.
Cooper KG, Kitchener HC, Parkin DE: Cerebral metastases from epithelial ovarian carcinoma treated with carboplatin. Gynecol Oncol 1994, 55: 318–323. 10.1006/gyno.1994.1297CrossRefPubMed
18.
Anupol N, Ghamande S, Odunsi K: Evaluation of prognostic factors and treatment modalities in ovarian cancer patients with brain metastases. Gynecol Oncol 2002, 85: 487–492. 10.1006/gyno.2002.6653CrossRefPubMed
19.
Ratner ES, Toy E, O’Malley DM, McAlpine J, Rutherford TJ, Azodi M, Higgins SA, Schwartz PE: Brain metastases in epithelial ovarian and primary peritoneal carcinoma. Int J Gynecol Cancer 2009, 19: 856–859. 10.1111/IGC.0b013e3181a83301CrossRefPubMed
20.
Gadducci A, Tana R, Teti G, Fanucchi A, Pasqualetti F, Cionini L, Genazzani AR: Brain recurrences in patients with ovarian cancer: report of 12 cases and review of the literature. Anticancer Res 2007, 27: 4403–4410.PubMed
21.
Brown JV, Goldstein BH, Duma CM, Rettenmaier MA, Micha JP: Gamma-knife radiosurgery for the treatment of ovarian cancer metastatic to the brain. Gynecol Oncol 2005, 97: 858–861. 10.1016/j.ygyno.2005.02.019CrossRefPubMed
22.
Navarro-Martín A, Maitz A, Manders M, Ducharme E, Chen P, Grills I: Gamma knife radiosurgery as a primary treatment option for solitary brain metastases from ovarian carcinoma. Clin Transl Oncol 2009, 11: 326–328. 10.1007/s12094-009-0362-6CrossRefPubMed
23.
Cox DR, Oakes D: Analysis of Survival Data. Chapman & Hall/CRC, Boca Raton; 1984.
24.
A Language and Environment for Statistical Computing. R Version 3.0.2. R Foundation for Statistical Computing, Vienna; 2014.
25.
Spiegelhalter D, Thomas A, Best N, Lunn D: WinBUGS. Version 1.4.3. Imperial College School of Medicine & Medical Research Council-Biostatistics Unit, Cambridge; 2003.
26.
Breiman L, Friedman JH, Stone CJ, Olshen RA: Classification and Regression Trees. Chapman & Hall/CRC, Boca Raton; 1984.
27.
Ripley B: Classification and Regression Trees. Version 1.0–35. R Foundation for Statistical Computing, Vienna; 2014.
28.
Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi G: Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 2006, 295: 2483–2491. 10.1001/jama.295.21.2483CrossRefPubMed
Metadata
Title
Stereotactic radiotherapy in epithelial ovarian cancer brain metastases patients
Authors
Agata Celejewska
Andrzej Tukiendorf
Leszek Miszczyk
Krzysztof Składowski
Jerzy Wydmański
Krystyna Trela-Janus
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Journal of Ovarian Research / Issue 1/2014
Electronic ISSN: 1757-2215
DOI
https://doi.org/10.1186/s13048-014-0079-1

Other articles of this Issue 1/2014

Journal of Ovarian Research 1/2014 Go to the issue

Research

Should zygote intrafallopian transfer be offered to all patients with unexplained repeated in-vitro fertilization cycle failures?

Research

Seasonal changes in expression of nerve growth factor and its receptors TrkA and p75 in the ovary of wild ground squirrel (Citellus dauricus Brandt)

Research

Antibodies against Hsp60 and Hsp65 in the sera of women with ovarian cancer

Research

Obesity and epithelial ovarian cancer survival: a systematic review and meta-analysis

Research

Epicardial adipose tissue thickness and NGAL levels in women with polycystic ovary syndrome

Research

Changes in granulosa cells gene expression associated with growth, plateau and atretic phases in medium bovine follicles