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Open Access 01-12-2017 | Letter to the Editor

Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

Authors: Bing Li, Robert Peter Gale, Zefeng Xu, Tiejun Qin, Zhen Song, Peihong Zhang, Jie Bai, Lei Zhang, Yue Zhang, Jinqin Liu, Gang Huang, Zhijian Xiao

Published in: Journal of Hematology & Oncology | Issue 1/2017

Abstract

We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2AF1, were significantly more frequent in PMF than in post-PV/ET MF (33 vs. 6%; P = 0.015). There were also striking differences in clonal architecture. These data indicate different genomic spectrums between PMF and post-PV/ET MF.

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Title: Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis
Authors: Bing Li
Robert Peter Gale
Zefeng Xu
Tiejun Qin
Zhen Song
Peihong Zhang
Jie Bai
Lei Zhang
Yue Zhang
Jinqin Liu
Gang Huang
Zhijian Xiao
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2017
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/s13045-017-0472-5

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