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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2016

Open Access 01-12-2016 | Letter to the Editor

Telomere length shortening is associated with treatment-free remission in chronic myeloid leukemia patients

Authors: Giovanni Caocci, Marianna Greco, Giuseppe Delogu, Christian Secchi, Bruno Martino, Claudia Labate, Elisabetta Abruzzese, Malgorzata Monika Trawinska, Sara Galimberti, Federica Orru, Claudio Fozza, Carlo Gambacorti Passerini, Francesco Galimi, Giorgio La Nasa

Published in: Journal of Hematology & Oncology | Issue 1/2016

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Abstract

We studied telomere length in 32 CML patients who discontinued imatinib after achieving complete molecular remission and 32 age-sex-matched controls. The relative telomere length (RTL) was determined by q-PCR as the telomere to single copy gene (36B4) ratio normalized to a reference sample (K-562 DNA). Age-corrected RTL (acRTL) was also obtained. The 36-month probability of treatment-free remission (TFR) was 59.4 %. TFR patients showed shorter acRTL compared to relapsed (mean ± SD = 0.01 ± 0.14 vs 0.20 ± 0.21; p = 0.01). TFR was significantly higher in CML patients with acRTL ≤0.09 (78.9 vs 30.8 %, p = 0.002). CML stem cells harboring longer telomeres possibly maintain a proliferative potential after treatment discontinuation.
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Metadata
Title
Telomere length shortening is associated with treatment-free remission in chronic myeloid leukemia patients
Authors
Giovanni Caocci
Marianna Greco
Giuseppe Delogu
Christian Secchi
Bruno Martino
Claudia Labate
Elisabetta Abruzzese
Malgorzata Monika Trawinska
Sara Galimberti
Federica Orru
Claudio Fozza
Carlo Gambacorti Passerini
Francesco Galimi
Giorgio La Nasa
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2016
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-016-0293-y

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