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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2016

Open Access 01-12-2016 | Letter to the Editor

Systematic analysis of overall survival and interactions between tumor mutations and drug treatment

Authors: Francesco Gatto, Jens Nielsen

Published in: Journal of Hematology & Oncology | Issue 1/2016

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Abstract

Background

Few exceptional responses in cancer treatment were attributed to a genetic predisposition of the tumor.

Methods

We analyzed a cohort of 3105 patients from 12 different cancer types and systematically sought the existence of a correlation between overall survival and the interaction of 21 antineoplastic treatments with 6 tumor mutations.

Results

We identified a single significant correlation resulting in increased overall survival from temozolomide in lower-grade glioma with IDH1 R132H mutations. The trend could not be attributed to either the treatment or the mutation alone. Univariate and multivariate Cox regression demonstrated that this interaction stood as an independent prognostic predictor of survival.

Conclusion

Our results suggest infrequent instances of exceptional responses ascribable to tumor genomics yet corroborate the existence of an interaction of temozolomide with IDH1 mutations in lower-grade glioma.
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Metadata
Title
Systematic analysis of overall survival and interactions between tumor mutations and drug treatment
Authors
Francesco Gatto
Jens Nielsen
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2016
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-016-0249-2

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