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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2015

Open Access 01-12-2015 | Review

Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia

Authors: Marion Lapierre, Audrey Castet-Nicolas, Delphine Gitenay, Stéphan Jalaguier, Catherine Teyssier, Caroline Bret, Guillaume Cartron, Jérôme Moreaux, Vincent Cavaillès

Published in: Journal of Hematology & Oncology | Issue 1/2015

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Abstract

RIP140 is a transcriptional coregulator, (also known as NRIP1), which finely tunes the activity of various transcription factors and plays very important physiological roles. Noticeably, the RIP140 gene has been implicated in the control of energy expenditure, behavior, cognition, mammary gland development and intestinal homeostasis. RIP140 is also involved in the regulation of various oncogenic signaling pathways and participates in the development and progression of solid tumors. During the past years, several papers have reported evidences linking RIP140 to hematologic malignancies. Among them, two recent studies with correlative data suggested that gene expression signatures including RIP140 can predict survival in chronic lymphocytic leukemia (CLL). This review aims to summarize the literature dealing with the expression of RIP140 in CLL and to explore the potential impact of this factor on transcription pathways which play key roles in this pathology.
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Metadata
Title
Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia
Authors
Marion Lapierre
Audrey Castet-Nicolas
Delphine Gitenay
Stéphan Jalaguier
Catherine Teyssier
Caroline Bret
Guillaume Cartron
Jérôme Moreaux
Vincent Cavaillès
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2015
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-015-0116-6

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