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Child and Adolescent Psychiatry and Mental Health
Published in: Child and Adolescent Psychiatry and Mental Health 1/2016

Open Access 01-12-2016 | Research article

A preliminary study of movement intensity during a Go/No-Go task and its association with ADHD outcomes and symptom severity

Authors: Fenghua Li, Yi Zheng, Stephanie D. Smith, Frederick Shic, Christina C. Moore, Xixi Zheng, Yanjie Qi, Zhengkui Liu, James F. Leckman

Published in: Child and Adolescent Psychiatry and Mental Health | Issue 1/2016

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Abstract

Objective

At present, there are no well-validated biomarkers for attention-deficit/hyperactivity disorder (ADHD). The present study used an infrared motion tracking system to monitor and record the movement intensity of children and to determine its diagnostic precision for ADHD and its possible associations with ratings of ADHD symptom severity.

Methods

A Microsoft motion sensing camera recorded the movement of children during a modified Go/No-Go Task. Movement intensity measures extracted from these data included a composite measure of total movement intensity (TMI measure) and a movement intensity distribution (MID measure) measure across 15 frequency bands (FB measures). In phase 1 of the study, 30 children diagnosed with ADHD or at subthreshold for ADHD and 30 matched healthy controls were compared to determine if measures of movement intensity successfully distinguished children with ADHD from healthy control children. In phase 2, associations between measures of movement intensity and clinician-rated ADHD symptom severity (Clinical Global Impression Scale [CGI] and the ADHD-Rating Scale IV [ADHD-RS]) were examined in a subset of children with ADHD (n = 14) from the phase I sample.

Results

Both measures of movement intensity were able to distinguish children with ADHD from healthy controls. However, only the measures linked to the 15 pre-determined 1 Hz frequency bands were significantly correlated with both the CGI scores and ADHD-RS total scores.

Conclusions

Preliminary findings suggest that measures of movement intensity, particularly measures linked to the 10–11 and 12–13 Hz frequency bands, have the potential to become valid biomarkers for ADHD.
Appendix
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Metadata
Title
A preliminary study of movement intensity during a Go/No-Go task and its association with ADHD outcomes and symptom severity
Authors
Fenghua Li
Yi Zheng
Stephanie D. Smith
Frederick Shic
Christina C. Moore
Xixi Zheng
Yanjie Qi
Zhengkui Liu
James F. Leckman
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Child and Adolescent Psychiatry and Mental Health / Issue 1/2016
Electronic ISSN: 1753-2000
DOI
https://doi.org/10.1186/s13034-016-0135-2

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