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BioPsychoSocial Medicine
Published in: BioPsychoSocial Medicine 1/2020

01-12-2020 | Heart Failure | Research

Higher galectin-3 levels are independently associated with lower anxiety in patients with risk factors for heart failure

Authors: Monika Sadlonova, Thomas Meyer, Lutz Binder, Rolf Wachter, Frank Edelmann, Christoph Herrmann-Lingen

Published in: BioPsychoSocial Medicine | Issue 1/2020

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Abstract

Background

Galectin-3 promotes the proliferation of neural progenitor cells and is engaged in cell-cell adhesion, cell-matrix interactions, and macrophage activation. In addition, in patients with heart failure this carbohydrate-binding protein is a known prognostic marker for cardiovascular mortality. However, its association with psychological variables has not been investigated so far.

Methods

Using data from the multicenter, observational Diast-CHF (Diagnostic Trial on Prevalence and Clinical Course of Diastolic Dysfunction and Heart Failure) trial, we studied in participants with cardiovascular risk factors (n = 1260, age 66.7 ± 8.0 years, males 51%, left ventricular ejection fraction 60.0 ± 8.1%) the relationship between serum concentrations of galectin-3 and anxiety. Galectin-3 levels were measured by means of a sandwich enzyme-linked immunosorbent assay, and anxiety was assessed using the Hospital Anxiety and Depression Scale (HADS).

Results

In univariate analysis, there was a weak but significant inverse correlation between galectin-3 and HADS anxiety (rho = − 0.076; p = 0.008). Linear regression models adjusted for sex, age, body-mass index, estimated glomerular filtration rate, left ventricular ejection fraction, 6-min walking distance, the 36-item Short-Form Health Survey (SF-36) subscale physical functioning, and known biomarkers for heart failure confirmed that serum galectin-3 significantly and independently predicted self-rated anxiety (B = -2.413; 95%CI = -2.413–-4.422; p = 0.019).

Conclusion

In patients with cardiovascular risk factors, serum concentrations of galectin-3 showed an inverse association with anxiety, which was independent of both the severity of physical impairment and established risk factors for the progression of heart failure.

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Metadata
Title
Higher galectin-3 levels are independently associated with lower anxiety in patients with risk factors for heart failure
Authors
Monika Sadlonova
Thomas Meyer
Lutz Binder
Rolf Wachter
Frank Edelmann
Christoph Herrmann-Lingen
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BioPsychoSocial Medicine / Issue 1/2020
Electronic ISSN: 1751-0759
DOI
https://doi.org/10.1186/s13030-020-00195-7

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