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Journal of Cardiothoracic Surgery
Published in: Journal of Cardiothoracic Surgery 1/2019

Open Access 01-12-2019 | Acute Kidney Injury | Research article

Cardiopulmonary bypass time is an independent risk factor for acute kidney injury in emergent thoracic aortic surgery: a retrospective cohort study

Authors: Shijun Xu, Jie Liu, Lei Li, Zining Wu, Jiachen Li, Yongmin Liu, Junming Zhu, Lizhong Sun, Xinliang Guan, Ming Gong, Hongjia Zhang

Published in: Journal of Cardiothoracic Surgery | Issue 1/2019

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Abstract

Background

Thoracic aortic surgery and cardiopulmonary bypass are both associated with development of postoperative acute kidney injury. In this study, we undertook to investigate the relationship between cardiopulmonary bypass time and postoperative acute kidney injury in patients undergoing thoracic aortic surgery for acute DeBakey Type I aortic dissection.

Methods

All patients receiving thoracic aortic surgery for acute DeBakey Type I aortic dissection in Beijing Anzhen hospital from December 2015 to April 2017 were included. Cardiopulmonary bypass time was recorded during surgery. Acute kidney injury was defined based on the Kidney Disease Improving Global Outcomes criteria. A total of 115 consecutive patients were eventually analyzed.

Results

The overall incidence of acute kidney injury was 53.0% (n = 61). The average age was 47.8 ± 10.7 years; 74.8% were male. Mean cardiopulmonary bypass time was 211 ± 56 min. In-hospital mortality was 7.8%. Multivariate logistic regression revealed that cardiopulmonary bypass time was independently associated with the occurrence of postoperative acute kidney injury after adjust confounding factors (odds ratio = 1.171; 95% confidence interval: 1.002–1.368; P = 0.047).

Conclusions

Cardiopulmonary bypass time is independently associated with an increased hazard of acute kidney injury after thoracic aortic surgery for acute DeBakey Type I aortic dissection. Further understanding of the mechanism of this association is crucial to the design of preventative strategies.
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Metadata
Title
Cardiopulmonary bypass time is an independent risk factor for acute kidney injury in emergent thoracic aortic surgery: a retrospective cohort study
Authors
Shijun Xu
Jie Liu
Lei Li
Zining Wu
Jiachen Li
Yongmin Liu
Junming Zhu
Lizhong Sun
Xinliang Guan
Ming Gong
Hongjia Zhang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2019
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/s13019-019-0907-x

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