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Journal of Cardiothoracic Surgery

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Open Access 01-12-2018 | Research article

Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study

Authors: Supomo Supomo, Handy Darmawan, Adika Zhulhi Arjana

Published in: Journal of Cardiothoracic Surgery | Issue 1/2018

Abstract

Background

The presence of altered pulmonary hemodynamics in adult patients with atrial septal defect (ASD) is common. However, there are no observational studies which evaluate the impact of altered pulmonary hemodynamics on the 6-min walk test (6MWT) result. This study aimed to investigate the role of pulmonary hemodynamics in determining 6MWT result of patients with ASD.

Method

Forty-six consecutive adult patients with ASD were included in this study. Right heart catheterization was performed to obtain the pulmonary hemodynamics profile. Meanwhile, 6MWT was presented as high or low with cut-off point 350 m. Receiver operating characteristic (ROC) was used for analytical methods.

Result

Abnormal functional capacity was indicated by ROC result of mPAP cut-off value of > 24 mmHg (p = 0.0243; AUC = 0.681). The value of PVR > 3.42 woods unit (WU) showed high specificity in determining abnormal functional capacity (p = 0.0069; AUC = 0.713). Flow ratio with cut-off point ≤4.89 had the highest sensitivity (100%) (p = 0.8300; AUC = 0.520).

Conclusion

Pulmonary hemodynamics can serve as an indicator of 6MWT result in adult ASD patients with values of mPAP> 24 mmHg and PVR > 3.42 WU.

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Title: Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study
Authors: Supomo Supomo
Handy Darmawan
Adika Zhulhi Arjana
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Journal of Cardiothoracic Surgery / Issue 1/2018
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-018-0725-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Role of pulmonary hemodynamics in determining 6-minute walk test result in atrial septal defect: an observational study

Abstract

Background

Method

Result

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Method

Result

Conclusion

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