Skip to main content
Top
Published in: Journal of Cardiothoracic Surgery 1/2018

Open Access 01-12-2018 | Research article

A standardized approach to treat complex aortic valve endocarditis: a case series

Authors: Anna Gomes, Jayant S. Jainandunsing, Sander van Assen, Peter Paul van Geel, Bhanu Sinha, Sandro Gelsomino, Daniel M. Johnson, Ehsan Natour

Published in: Journal of Cardiothoracic Surgery | Issue 1/2018

Login to get access

Abstract

Background

Surgical treatment of complicated aortic valve endocarditis often is challenging, even for experienced surgeons. We aim at demonstrating a standardized surgical approach by stentless bioprostheses for the treatment of aortic valve endocarditis complicated by paravalvular abscess formation.

Methods

Sixteen patients presenting with aortic valve endocarditis (4 native and 12 prosthetic valves) and paravalvular abscess formation at various localizations and to different extents were treated by a standardized approach using stentless bioprostheses. The procedure consisted of thorough debridement, root replacement with reimplantation of the coronary arteries and correction of accompanying pathologies (aortoventricular and aortomitral dehiscence, septum derangements, Gerbode defect, total atrioventricular conduction block, mitral and tricuspid valve involvement).

Results

All highly complex patients included (14 males and 2 females; median age 63 years [range 31–77]) could be successfully treated with stentless bioprostheses as aortic root replacement. Radical surgical debridement of infected tissue with anatomical recontruction was feasible. Although predicted operative mortality was high (median logarithmic EuroSCORE I of 40.7 [range 12.8–68.3]), in-hospital and 30-day mortality rates were favorable (18.8 and 12.5% respectively).

Conclusions

Repair of active aortic valve endocarditis complicated by paravalvular abscess formation and destruction of the left ventricular outflow tract with stentless bioprosthesis is a valuable option for both native and prosthetic valves. It presents a standardized approach with a high success rate for complete debridement, is readily available, and yields comparable clinical outcomes to the historical gold standard, repair by homografts. Additionally, use of one type of prosthesis reduces logistical issues and purchasing costs.
Literature
1.
go back to reference Murdoch DR, Corey GR, Hoen B, Miro JM, Fowler VG, Jr BAS, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the international collaboration on endocarditis-prospective cohort study. Arch Intern Med. 2009;169(5):463–73.CrossRefPubMedPubMedCentral Murdoch DR, Corey GR, Hoen B, Miro JM, Fowler VG, Jr BAS, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the international collaboration on endocarditis-prospective cohort study. Arch Intern Med. 2009;169(5):463–73.CrossRefPubMedPubMedCentral
2.
go back to reference Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, et al. 2015 ESC guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36(44):3075–128.CrossRefPubMed Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, et al. 2015 ESC guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36(44):3075–128.CrossRefPubMed
4.
go back to reference Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG, Jr RT, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000;30(4):633–8.CrossRefPubMed Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG, Jr RT, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000;30(4):633–8.CrossRefPubMed
5.
go back to reference Prendergast BD, Tornos P. Surgery for infective endocarditis: who and when? Circulation. 2010;121(9):1141–52.CrossRefPubMed Prendergast BD, Tornos P. Surgery for infective endocarditis: who and when? Circulation. 2010;121(9):1141–52.CrossRefPubMed
6.
go back to reference Vikram HR, Buenconsejo J, Hasbun R, Quagliarello VJ. Impact of valve surgery on 6-month mortality in adults with complicated, left-sided native valve endocarditis: a propensity analysis. JAMA. 2003;290(24):3207–14.CrossRefPubMed Vikram HR, Buenconsejo J, Hasbun R, Quagliarello VJ. Impact of valve surgery on 6-month mortality in adults with complicated, left-sided native valve endocarditis: a propensity analysis. JAMA. 2003;290(24):3207–14.CrossRefPubMed
7.
go back to reference Kang DH, Kim YJ, Kim SH, Sun BJ, Kim DH, Yun SC, et al. Early surgery versus conventional treatment for infective endocarditis. N Engl J Med. 2012;366(26):2466–73.CrossRefPubMed Kang DH, Kim YJ, Kim SH, Sun BJ, Kim DH, Yun SC, et al. Early surgery versus conventional treatment for infective endocarditis. N Engl J Med. 2012;366(26):2466–73.CrossRefPubMed
8.
go back to reference Schneider AW, Hazekamp MG, Versteegh MI, Bruggemans EF, Holman ER, Klautz RJ, et al. Stentless bioprostheses: a versatile and durable solution in extensive aortic valve endocarditis. Eur J Cardiothorac Surg. 2016;49(6):1699–704.CrossRefPubMed Schneider AW, Hazekamp MG, Versteegh MI, Bruggemans EF, Holman ER, Klautz RJ, et al. Stentless bioprostheses: a versatile and durable solution in extensive aortic valve endocarditis. Eur J Cardiothorac Surg. 2016;49(6):1699–704.CrossRefPubMed
9.
go back to reference Sponga S, Daffarra C, Pavoni D, Vendramin I, Mazzaro E, Piani D, et al. Surgical management of destructive aortic endocarditis: left ventricular outflow reconstruction with the Sorin Pericarbon freedom stentless bioprosthesis dagger. Eur J Cardiothorac Surg. 2016;49(1):242–8.CrossRefPubMed Sponga S, Daffarra C, Pavoni D, Vendramin I, Mazzaro E, Piani D, et al. Surgical management of destructive aortic endocarditis: left ventricular outflow reconstruction with the Sorin Pericarbon freedom stentless bioprosthesis dagger. Eur J Cardiothorac Surg. 2016;49(1):242–8.CrossRefPubMed
10.
go back to reference Byrne JG, Rezai K, Sanchez JA, Bernstein RA, Okum E, Leacche M, et al. Surgical management of endocarditis: the society of thoracic surgeons clinical practice guideline. Ann Thorac Surg. 2011;91(6):2012–9.CrossRefPubMed Byrne JG, Rezai K, Sanchez JA, Bernstein RA, Okum E, Leacche M, et al. Surgical management of endocarditis: the society of thoracic surgeons clinical practice guideline. Ann Thorac Surg. 2011;91(6):2012–9.CrossRefPubMed
11.
go back to reference Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr, Faxon DP, Freed MD, et al. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (writing committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2008;52(13):e1–142.CrossRefPubMed Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr, Faxon DP, Freed MD, et al. 2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (writing committee to revise the 1998 guidelines for the management of patients with valvular heart disease). Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2008;52(13):e1–142.CrossRefPubMed
12.
go back to reference Sabik JF, Lytle BW, Blackstone EH, Marullo AG, Pettersson GB, Cosgrove DM. Aortic root replacement with cryopreserved allograft for prosthetic valve endocarditis. Ann Thorac Surg. 2002;74(3):650–9.CrossRefPubMed Sabik JF, Lytle BW, Blackstone EH, Marullo AG, Pettersson GB, Cosgrove DM. Aortic root replacement with cryopreserved allograft for prosthetic valve endocarditis. Ann Thorac Surg. 2002;74(3):650–9.CrossRefPubMed
13.
go back to reference Perrotta S, Lentini S. In patients with severe active aortic valve endocarditis, is a stentless valve as good as the homograft? Interact Cardiovasc Thorac Surg. 2010;11(3):309–13.CrossRefPubMed Perrotta S, Lentini S. In patients with severe active aortic valve endocarditis, is a stentless valve as good as the homograft? Interact Cardiovasc Thorac Surg. 2010;11(3):309–13.CrossRefPubMed
14.
go back to reference Heinz A, Dumfarth J, Ruttmann-Ulmer E, Grimm M, Muller LC. Freestyle root replacement for complex destructive aortic valve endocarditis. J Thorac Cardiovasc Surg. 2014;147(4):1265–70.CrossRefPubMed Heinz A, Dumfarth J, Ruttmann-Ulmer E, Grimm M, Muller LC. Freestyle root replacement for complex destructive aortic valve endocarditis. J Thorac Cardiovasc Surg. 2014;147(4):1265–70.CrossRefPubMed
15.
go back to reference Savage EB, Saha-Chaudhuri P, Asher CR, Brennan JM, Gammie JS. Outcomes and prosthesis choice for active aortic valve infective endocarditis: analysis of the Society of Thoracic Surgeons adult cardiac surgery database. Ann Thorac Surg. 2014;98(3):806–14.CrossRefPubMed Savage EB, Saha-Chaudhuri P, Asher CR, Brennan JM, Gammie JS. Outcomes and prosthesis choice for active aortic valve infective endocarditis: analysis of the Society of Thoracic Surgeons adult cardiac surgery database. Ann Thorac Surg. 2014;98(3):806–14.CrossRefPubMed
16.
go back to reference Miceli A, Croccia M, Simeoni S, Varone E, Murzi M, Farneti PA, et al. Root replacement with stentless freestyle bioprostheses for active endocarditis: a single Centre experience. Interact Cardiovasc Thorac Surg. 2013;16(1):27–30.CrossRefPubMed Miceli A, Croccia M, Simeoni S, Varone E, Murzi M, Farneti PA, et al. Root replacement with stentless freestyle bioprostheses for active endocarditis: a single Centre experience. Interact Cardiovasc Thorac Surg. 2013;16(1):27–30.CrossRefPubMed
17.
go back to reference Edlin P, Sartipy U. Freestyle xenograft for aortic valve endocarditis. J Thorac Cardiovasc Surg. 2014;147(1):542–3.CrossRefPubMed Edlin P, Sartipy U. Freestyle xenograft for aortic valve endocarditis. J Thorac Cardiovasc Surg. 2014;147(1):542–3.CrossRefPubMed
18.
go back to reference El-Hamamsy I, Clark L, Stevens LM, Sarang Z, Melina G, Takkenberg JJ, et al. Late outcomes following freestyle versus homograft aortic root replacement: results from a prospective randomized trial. J Am Coll Cardiol. 2010;55(4):368–76.CrossRefPubMed El-Hamamsy I, Clark L, Stevens LM, Sarang Z, Melina G, Takkenberg JJ, et al. Late outcomes following freestyle versus homograft aortic root replacement: results from a prospective randomized trial. J Am Coll Cardiol. 2010;55(4):368–76.CrossRefPubMed
19.
go back to reference Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2014;63(22):e57–185.CrossRefPubMed Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2014;63(22):e57–185.CrossRefPubMed
20.
go back to reference Davies A, Lai K, Bastian B. Acquired Gerbode defects associated with infective endocarditis. Heart Lung Circ. 2016;25(3):e59–61.CrossRefPubMed Davies A, Lai K, Bastian B. Acquired Gerbode defects associated with infective endocarditis. Heart Lung Circ. 2016;25(3):e59–61.CrossRefPubMed
21.
go back to reference Dapunt OE, Easo J, Holzl PP, Murin P, Sudkamp M, Horst M, et al. Stentless full root bioprosthesis in surgery for complex aortic valve-ascending aortic disease: a single center experience of over 300 patients. Eur J Cardiothorac Surg. 2008;33(4):554–9.CrossRefPubMed Dapunt OE, Easo J, Holzl PP, Murin P, Sudkamp M, Horst M, et al. Stentless full root bioprosthesis in surgery for complex aortic valve-ascending aortic disease: a single center experience of over 300 patients. Eur J Cardiothorac Surg. 2008;33(4):554–9.CrossRefPubMed
22.
go back to reference Bozbuga N, Erentug V, Erdogan HB, Kirali K, Ardal H, Tas S, et al. Surgical treatment of aortic abscess and fistula. Tex Heart Inst J. 2004;31(4):382–6.PubMedPubMedCentral Bozbuga N, Erentug V, Erdogan HB, Kirali K, Ardal H, Tas S, et al. Surgical treatment of aortic abscess and fistula. Tex Heart Inst J. 2004;31(4):382–6.PubMedPubMedCentral
23.
go back to reference Borger MA, Prasongsukarn K, Armstrong S, Feindel CM, David TE. Stentless aortic valve reoperations: a surgical challenge. Ann Thorac Surg. 2007;84(3):737–44.CrossRefPubMed Borger MA, Prasongsukarn K, Armstrong S, Feindel CM, David TE. Stentless aortic valve reoperations: a surgical challenge. Ann Thorac Surg. 2007;84(3):737–44.CrossRefPubMed
Metadata
Title
A standardized approach to treat complex aortic valve endocarditis: a case series
Authors
Anna Gomes
Jayant S. Jainandunsing
Sander van Assen
Peter Paul van Geel
Bhanu Sinha
Sandro Gelsomino
Daniel M. Johnson
Ehsan Natour
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Journal of Cardiothoracic Surgery / Issue 1/2018
Electronic ISSN: 1749-8090
DOI
https://doi.org/10.1186/s13019-018-0715-8

Other articles of this Issue 1/2018

Journal of Cardiothoracic Surgery 1/2018 Go to the issue