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Journal of Orthopaedic Surgery and Research
Published in: Journal of Orthopaedic Surgery and Research 1/2017

Open Access 01-12-2017 | Research article

Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis

Authors: Zheng Hao, Xin Li, Jin Dai, Baocheng Zhao, Qing Jiang

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2017

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Abstract

Background

Knee osteoarthritis (OA) is a complex arthritic condition in which genetic factors play an important role. ADAM12 gene is one of the recognized candidate genes although the results are conflicting. To derive a more precise estimation of the association between rs3740199 polymorphism in ADAM12 gene and risk of knee OA, we performed a meta-analysis based on six related studies, including a total of 2185 cases and 3716 controls.

Methods

A comprehensive search was performed to identify related studies up to April 14, 2017. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Different genetic models were used to assess the pooled and stratified data.

Results

Overall, no significant association was found in all genetic models (C vs. G, OR = 0.983, 95% CI = 0.910–1.061; CC vs. GG, OR = 1.033, 95% CI = 0.851–1.255; CG vs. GG, OR = 1.030, 95% CI = 0.877–1.209; CC/CG vs. GG, OR = 1.031, 95% CI = 0.886–1.201; CC vs. CG/GG, OR = 1.017, 95% CI = 0.868–1.190). When stratified by ethnicity, no significant association was found.

Conclusions

This meta-analysis suggested that the rs3740199 polymorphism does not contribute to the development of knee OA. Additional well-designed large studies are required to confirm these findings in different populations.
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Metadata
Title
Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis
Authors
Zheng Hao
Xin Li
Jin Dai
Baocheng Zhao
Qing Jiang
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2017
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/s13018-017-0594-z

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