Skip to main content
Top
Published in: Journal of Orthopaedic Surgery and Research 1/2017

Open Access 01-12-2017 | Technical note

Investigation and management of osteoporosis in aged trauma patients: a treatment algorithm adapted to the German guidelines for osteoporosis

Authors: Carl Neuerburg, Lena Mittlmeier, Ralf Schmidmaier, Christian Kammerlander, Wolfgang Böcker, Wolf Mutschler, Ulla Stumpf

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2017

Login to get access

Abstract

Background

Osteoporosis-associated fractures are of increasing importance in trauma surgery. Systematic diagnostics and treatment of osteoporosis during a hospital stay, however, remain inadequate. Therefore, a specific algorithm for diagnosing and treating osteoporosis in trauma surgery patients was developed based on the DVO (German Osteology Society) guideline for osteoporosis from 2014.

Methods

In a first step, the individuals’ age and risk profile for osteoporosis is identified considering specific fractures indicating osteoporosis and risk factors assessed by a specific questionnaire. In addition, physical activity, risk of falls, dietary habits and the individuals’ medication are considered. Basic osteoporosis laboratory tests, a bone densitometry by dual-energy X-ray absorptiometry (DXA) and, if needed, X-rays of the spine are carried out to identify prevalent vertebral body fractures.

Results

Based on the treatment algorithm adapted to the new guidelines for osteoporosis in the majority of proximal femoral fractures, treatment of osteoporosis could already be indicated without prior DXA. In case of preexisting glucocorticoid therapy, a history of previous fractures or other risk factors according to the risk questionnaire, the threshold of treatment has to be adjusted given the table of T-scores.

Conclusions

The treatment algorithm for diagnosing and treating osteoporosis in in-patient trauma surgery patients can help identify high-risk patients systematically and efficiently. As a result, osteoporosis-associated fractures or failure of osteosynthesis could be reduced, yet a prospective validation of the algorithm has to be completed.
Literature
1.
go back to reference Haussler B, Gothe H, Gol D, Glaeske G, Pientka L, Felsenberg D. Epidemiology, treatment and costs of osteoporosis in Germany—the BoneEVA Study. Osteoporos Int. 2007;18(1):77–84.CrossRefPubMed Haussler B, Gothe H, Gol D, Glaeske G, Pientka L, Felsenberg D. Epidemiology, treatment and costs of osteoporosis in Germany—the BoneEVA Study. Osteoporos Int. 2007;18(1):77–84.CrossRefPubMed
2.
go back to reference Hadji P, Klein S, Gothe H, Häussler B, Kless T, Schmidt T, Steinle T, Verheyen F, Linder R. Epidemiologie der Osteoporose - Bone Evaluation Study: Eine Analyse von Krankenkassen-Routinedaten. Dtsch Arztebl Int. 2013;110(4):52–7.PubMedPubMedCentral Hadji P, Klein S, Gothe H, Häussler B, Kless T, Schmidt T, Steinle T, Verheyen F, Linder R. Epidemiologie der Osteoporose - Bone Evaluation Study: Eine Analyse von Krankenkassen-Routinedaten. Dtsch Arztebl Int. 2013;110(4):52–7.PubMedPubMedCentral
3.
go back to reference Hadji P, Klein S, Haussler B, Kless T, Linder R, Rowinski-Jablokow M, Verheyen F, Gothe H. The bone evaluation study (BEST): patient care and persistence to treatment of osteoporosis in Germany. Int J Clin Pharmacol Ther. 2013;51(11):868–72.CrossRefPubMed Hadji P, Klein S, Haussler B, Kless T, Linder R, Rowinski-Jablokow M, Verheyen F, Gothe H. The bone evaluation study (BEST): patient care and persistence to treatment of osteoporosis in Germany. Int J Clin Pharmacol Ther. 2013;51(11):868–72.CrossRefPubMed
5.
go back to reference Cooper C. Osteoporosis: disease severity and consequent fracture management. Osteoporos Int. 2010;21 Suppl 2:S425–9.CrossRefPubMed Cooper C. Osteoporosis: disease severity and consequent fracture management. Osteoporos Int. 2010;21 Suppl 2:S425–9.CrossRefPubMed
6.
go back to reference Haasters F, Prall WC, Himmler M, Polzer H, Schieker M, Mutschler W. Prevalence and management of osteoporosis in trauma surgery: implementation of national guidelines during inpatient fracture treatment. Unfallchirurg. 2015;118(2):138–45.CrossRefPubMed Haasters F, Prall WC, Himmler M, Polzer H, Schieker M, Mutschler W. Prevalence and management of osteoporosis in trauma surgery: implementation of national guidelines during inpatient fracture treatment. Unfallchirurg. 2015;118(2):138–45.CrossRefPubMed
7.
go back to reference Kolios L, Takur C, Moghaddam A, Hitzler M, Schmidt-Gayk H, Suda AJ, Honer B, Grutzner PA, Wolfl C. Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density). BMC Musculoskelet Disord. 2011;12:187.CrossRefPubMedPubMedCentral Kolios L, Takur C, Moghaddam A, Hitzler M, Schmidt-Gayk H, Suda AJ, Honer B, Grutzner PA, Wolfl C. Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density). BMC Musculoskelet Disord. 2011;12:187.CrossRefPubMedPubMedCentral
8.
go back to reference Hippisley-Cox J, Coupland C. Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. BMJ. 2012;344, e3427.CrossRefPubMed Hippisley-Cox J, Coupland C. Derivation and validation of updated QFracture algorithm to predict risk of osteoporotic fracture in primary care in the United Kingdom: prospective open cohort study. BMJ. 2012;344, e3427.CrossRefPubMed
9.
go back to reference Strom O, Jonsson B, Kanis JA. Intervention thresholds for denosumab in the UK using a FRAX(R)-based cost-effectiveness analysis. Osteoporos Int. 2013;24(4):1491–502.CrossRefPubMed Strom O, Jonsson B, Kanis JA. Intervention thresholds for denosumab in the UK using a FRAX(R)-based cost-effectiveness analysis. Osteoporos Int. 2013;24(4):1491–502.CrossRefPubMed
10.
go back to reference Jamal SA, Leiter RE, Bayoumi AM, Bauer DC, Cummings SR. Clinical utility of laboratory testing in women with osteoporosis. Osteoporos Int. 2005;16(5):534–40.CrossRefPubMed Jamal SA, Leiter RE, Bayoumi AM, Bauer DC, Cummings SR. Clinical utility of laboratory testing in women with osteoporosis. Osteoporos Int. 2005;16(5):534–40.CrossRefPubMed
11.
go back to reference Willburger RE, Knorth H. Osteoporose der Wirbelsäule: Therapieoption und Präventionsstrategien. Dtsch Arztebl Int. 2003;100(17):1120. Willburger RE, Knorth H. Osteoporose der Wirbelsäule: Therapieoption und Präventionsstrategien. Dtsch Arztebl Int. 2003;100(17):1120.
12.
go back to reference Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jonsson B, Kanis JA. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013;8(1–2):136.CrossRefPubMedPubMedCentral Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jonsson B, Kanis JA. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013;8(1–2):136.CrossRefPubMedPubMedCentral
13.
go back to reference Kanis JA, Johnell O, De Laet C, Johansson H, Oden A, Delmas P, Eisman J, Fujiwara S, Garnero P, Kroger H, et al. A meta-analysis of previous fracture and subsequent fracture risk. Bone. 2004;35(2):375–82.CrossRefPubMed Kanis JA, Johnell O, De Laet C, Johansson H, Oden A, Delmas P, Eisman J, Fujiwara S, Garnero P, Kroger H, et al. A meta-analysis of previous fracture and subsequent fracture risk. Bone. 2004;35(2):375–82.CrossRefPubMed
14.
go back to reference El Maghraoui A, Rezqi A, Mounach A, Achemlal L, Bezza A, Dehhaoui M, Ghozlani I. Vertebral fractures and abdominal aortic calcification in postmenopausal women. A cohort study. Bone. 2013;56(1):213–9.CrossRefPubMed El Maghraoui A, Rezqi A, Mounach A, Achemlal L, Bezza A, Dehhaoui M, Ghozlani I. Vertebral fractures and abdominal aortic calcification in postmenopausal women. A cohort study. Bone. 2013;56(1):213–9.CrossRefPubMed
15.
go back to reference Tenne M, McGuigan F, Besjakov J, Gerdhem P, Akesson K. Degenerative changes at the lumbar spine—implications for bone mineral density measurement in elderly women. Osteoporos Int. 2013;24(4):1419–28.CrossRefPubMed Tenne M, McGuigan F, Besjakov J, Gerdhem P, Akesson K. Degenerative changes at the lumbar spine—implications for bone mineral density measurement in elderly women. Osteoporos Int. 2013;24(4):1419–28.CrossRefPubMed
16.
go back to reference Genant HK, Wu CY, van Kuijk C, Nevitt MC. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res. 1993;8(9):1137–48.CrossRefPubMed Genant HK, Wu CY, van Kuijk C, Nevitt MC. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res. 1993;8(9):1137–48.CrossRefPubMed
17.
go back to reference Jurisson M, Pisarev H, Kanis J, Borgstrom F, Svedbom A, Kallikorm R, Lember M, Uuskula A. Quality of life, resource use, and costs related to hip fracture in Estonia. Osteoporos Int. 2016;27(8):2555–66.CrossRefPubMed Jurisson M, Pisarev H, Kanis J, Borgstrom F, Svedbom A, Kallikorm R, Lember M, Uuskula A. Quality of life, resource use, and costs related to hip fracture in Estonia. Osteoporos Int. 2016;27(8):2555–66.CrossRefPubMed
18.
go back to reference Lyles KW, Colon-Emeric CS, Magaziner JS, Adachi JD, Pieper CF, Mautalen C, Hyldstrup L, Recknor C, Nordsletten L, Moore KA, et al. Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med. 2007;357(18):1799–809.CrossRefPubMed Lyles KW, Colon-Emeric CS, Magaziner JS, Adachi JD, Pieper CF, Mautalen C, Hyldstrup L, Recknor C, Nordsletten L, Moore KA, et al. Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med. 2007;357(18):1799–809.CrossRefPubMed
19.
go back to reference Frerichmann U, Raschke MJ, Stockle U, Wohrmann S, Lohmann R. Proximal femoral fractures in the elderly. Data from health insurance providers on more than 23 million insured persons—part 2. Unfallchirurg. 2007;110(7):610–6.CrossRefPubMed Frerichmann U, Raschke MJ, Stockle U, Wohrmann S, Lohmann R. Proximal femoral fractures in the elderly. Data from health insurance providers on more than 23 million insured persons—part 2. Unfallchirurg. 2007;110(7):610–6.CrossRefPubMed
20.
go back to reference Vogel T, Dobler T, Bitterling H, Biberthaler P, Kanz KG, Pfeifer KJ, Bartl R, Mutschler W. Osteoporosis in traumatology. Prevalence and management. Unfallchirurg. 2005;108(5):356–64.CrossRefPubMed Vogel T, Dobler T, Bitterling H, Biberthaler P, Kanz KG, Pfeifer KJ, Bartl R, Mutschler W. Osteoporosis in traumatology. Prevalence and management. Unfallchirurg. 2005;108(5):356–64.CrossRefPubMed
21.
go back to reference Förtsch M, Schmidt T, Feldmann C, Maurer T. DVO-Leitlinie (DVO: Dachverband Osteologie) in der osteologischen Schwerpunktpraxis. Trauma Berufskrankh. 2014;16(2):110–21.CrossRef Förtsch M, Schmidt T, Feldmann C, Maurer T. DVO-Leitlinie (DVO: Dachverband Osteologie) in der osteologischen Schwerpunktpraxis. Trauma Berufskrankh. 2014;16(2):110–21.CrossRef
22.
go back to reference Ahmed LA, Emaus N, Berntsen GK, Bjornerem A, Fonnebo V, Jorgensen L, Schirmer H, Stormer J, Joakimsen RM. Bone loss and the risk of non-vertebral fractures in women and men: the Tromso study. Osteoporos Int. 2010;21(9):1503–11.CrossRefPubMed Ahmed LA, Emaus N, Berntsen GK, Bjornerem A, Fonnebo V, Jorgensen L, Schirmer H, Stormer J, Joakimsen RM. Bone loss and the risk of non-vertebral fractures in women and men: the Tromso study. Osteoporos Int. 2010;21(9):1503–11.CrossRefPubMed
23.
go back to reference Kanterewicz E, Puigoriol E, Garcia-Barrionuevo J, del Rio L, Casellas M, Peris P. Prevalence of vertebral fractures and minor vertebral deformities evaluated by DXA-assisted vertebral fracture assessment (VFA) in a population-based study of postmenopausal women: the FRODOS study. Osteoporos Int. 2014;25(5):1455–64.PubMed Kanterewicz E, Puigoriol E, Garcia-Barrionuevo J, del Rio L, Casellas M, Peris P. Prevalence of vertebral fractures and minor vertebral deformities evaluated by DXA-assisted vertebral fracture assessment (VFA) in a population-based study of postmenopausal women: the FRODOS study. Osteoporos Int. 2014;25(5):1455–64.PubMed
24.
go back to reference Gehlbach S, Saag KG, Adachi JD, Hooven FH, Flahive J, Boonen S, Chapurlat RD, Compston JE, Cooper C, Diez-Perez A, et al. Previous fractures at multiple sites increase the risk for subsequent fractures: the Global Longitudinal Study of Osteoporosis in Women. J Bone Miner Res. 2012;27(3):645–53.CrossRefPubMedPubMedCentral Gehlbach S, Saag KG, Adachi JD, Hooven FH, Flahive J, Boonen S, Chapurlat RD, Compston JE, Cooper C, Diez-Perez A, et al. Previous fractures at multiple sites increase the risk for subsequent fractures: the Global Longitudinal Study of Osteoporosis in Women. J Bone Miner Res. 2012;27(3):645–53.CrossRefPubMedPubMedCentral
25.
go back to reference Kim TY, Ha YC, Kang BJ, Lee YK, Koo KH. Does early administration of bisphosphonate affect fracture healing in patients with intertrochanteric fractures? J Bone Joint SurgBr. 2012;94(7):956–60.CrossRef Kim TY, Ha YC, Kang BJ, Lee YK, Koo KH. Does early administration of bisphosphonate affect fracture healing in patients with intertrochanteric fractures? J Bone Joint SurgBr. 2012;94(7):956–60.CrossRef
26.
go back to reference McDonald MM, Dulai S, Godfrey C, Amanat N, Sztynda T, Little DG. Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. Bone. 2008;43(4):653–62.CrossRefPubMed McDonald MM, Dulai S, Godfrey C, Amanat N, Sztynda T, Little DG. Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. Bone. 2008;43(4):653–62.CrossRefPubMed
27.
go back to reference Dhert WJ, Thomsen P, Blomgren AK, Esposito M, Ericson LE, Verbout AJ. Integration of press-fit implants in cortical bone: a study on interface kinetics. J Biomed Mater Res. 1998;41(4):574–83.CrossRefPubMed Dhert WJ, Thomsen P, Blomgren AK, Esposito M, Ericson LE, Verbout AJ. Integration of press-fit implants in cortical bone: a study on interface kinetics. J Biomed Mater Res. 1998;41(4):574–83.CrossRefPubMed
28.
go back to reference Nehme A, Maalouf G, Tricoire JL, Giordano G, Chiron P, Puget J. Effect of alendronate on periprosthetic bone loss after cemented primary total hip arthroplasty: a prospective randomized study. Rev Chir Orthop Reparatrice Appar Mot. 2003;89(7):593–8.PubMed Nehme A, Maalouf G, Tricoire JL, Giordano G, Chiron P, Puget J. Effect of alendronate on periprosthetic bone loss after cemented primary total hip arthroplasty: a prospective randomized study. Rev Chir Orthop Reparatrice Appar Mot. 2003;89(7):593–8.PubMed
30.
go back to reference Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, et al. Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344(19):1434–41.CrossRefPubMed Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, et al. Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344(19):1434–41.CrossRefPubMed
31.
go back to reference Cauley JA, Parimi N, Ensrud KE, Bauer DC, Cawthon PM, Cummings SR, Hoffman AR, Shikany JM, Barrett-Connor E, Orwoll E, et al. Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. J Bone Miner Res. 2010;25(3):545–53.CrossRefPubMed Cauley JA, Parimi N, Ensrud KE, Bauer DC, Cawthon PM, Cummings SR, Hoffman AR, Shikany JM, Barrett-Connor E, Orwoll E, et al. Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. J Bone Miner Res. 2010;25(3):545–53.CrossRefPubMed
32.
go back to reference Garnero P, Munoz F, Sornay-Rendu E, Delmas PD. Associations of vitamin D status with bone mineral density, bone turnover, bone loss and fracture risk in healthy postmenopausal women. The OFELY study. Bone. 2007;40(3):716–22.CrossRefPubMed Garnero P, Munoz F, Sornay-Rendu E, Delmas PD. Associations of vitamin D status with bone mineral density, bone turnover, bone loss and fracture risk in healthy postmenopausal women. The OFELY study. Bone. 2007;40(3):716–22.CrossRefPubMed
33.
go back to reference Bischoff-Ferrari HA. Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes. Adv Exp Med Biol. 2014;810:500–25.PubMed Bischoff-Ferrari HA. Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes. Adv Exp Med Biol. 2014;810:500–25.PubMed
34.
go back to reference Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, Flicker L, Wark J, Jackson RD, Cauley JA, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367(1):40–9.CrossRefPubMed Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, Flicker L, Wark J, Jackson RD, Cauley JA, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367(1):40–9.CrossRefPubMed
35.
go back to reference Drey M, Bollheimer C. Vitamin D supplementation in the elderly. Dtsch Med Wochenschr. 2011;136(48):2463–5.CrossRefPubMed Drey M, Bollheimer C. Vitamin D supplementation in the elderly. Dtsch Med Wochenschr. 2011;136(48):2463–5.CrossRefPubMed
36.
go back to reference Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine S. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30.CrossRefPubMed Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine S. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30.CrossRefPubMed
37.
go back to reference Holick MF, Matsuoka LY, Wortsman J. Age, vitamin D, and solar ultraviolet. Lancet. 1989;2(8671):1104–5.CrossRefPubMed Holick MF, Matsuoka LY, Wortsman J. Age, vitamin D, and solar ultraviolet. Lancet. 1989;2(8671):1104–5.CrossRefPubMed
38.
go back to reference Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001;22(4):477–501.CrossRefPubMed Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001;22(4):477–501.CrossRefPubMed
39.
go back to reference Bacon CJ, Gamble GD, Horne AM, Scott MA, Reid IR. High-dose oral vitamin D3 supplementation in the elderly. Osteoporos Int. 2009;20(8):1407–15.CrossRefPubMed Bacon CJ, Gamble GD, Horne AM, Scott MA, Reid IR. High-dose oral vitamin D3 supplementation in the elderly. Osteoporos Int. 2009;20(8):1407–15.CrossRefPubMed
40.
go back to reference Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. Jama. 2010;303(18):1815–22.CrossRefPubMed Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. Jama. 2010;303(18):1815–22.CrossRefPubMed
41.
go back to reference Lewis JR, Barre D, Zhu K, Ivey KL, Lim EM, Hughes J, Prince RL. Long-term proton pump inhibitor therapy and falls and fractures in elderly women: a prospective cohort study. J Bone Miner Res. 2014;29(11):2489–97.CrossRefPubMed Lewis JR, Barre D, Zhu K, Ivey KL, Lim EM, Hughes J, Prince RL. Long-term proton pump inhibitor therapy and falls and fractures in elderly women: a prospective cohort study. J Bone Miner Res. 2014;29(11):2489–97.CrossRefPubMed
42.
go back to reference Maggio M, Lauretani F, Ceda GP, De Vita F, Bondi G, Corsonello A, Cattabiani C, Lattanzio F, Ruggiero C, Nouvenne A, et al. Use of proton pump inhibitors is associated with lower trabecular bone density in older individuals. Bone. 2013;57(2):437–42.CrossRefPubMed Maggio M, Lauretani F, Ceda GP, De Vita F, Bondi G, Corsonello A, Cattabiani C, Lattanzio F, Ruggiero C, Nouvenne A, et al. Use of proton pump inhibitors is associated with lower trabecular bone density in older individuals. Bone. 2013;57(2):437–42.CrossRefPubMed
43.
go back to reference Ding J, Heller DA, Ahern FM, Brown TV. The relationship between proton pump inhibitor adherence and fracture risk in the elderly. Calcif Tissue Int. 2014;94(6):597–607.CrossRefPubMed Ding J, Heller DA, Ahern FM, Brown TV. The relationship between proton pump inhibitor adherence and fracture risk in the elderly. Calcif Tissue Int. 2014;94(6):597–607.CrossRefPubMed
44.
go back to reference Leitlinienreport zur S3-Leitlinie: Bisphosphonat- assoziierte Kiefernekrose (BP-ONJ) und andere Medikamenten-assoziierte Kiefernekrosen. AWMF-Register-Nr 007-091 2012. Leitlinienreport zur S3-Leitlinie: Bisphosphonat- assoziierte Kiefernekrose (BP-ONJ) und andere Medikamenten-assoziierte Kiefernekrosen. AWMF-Register-Nr 007-091 2012.
45.
go back to reference Gertz BJ, Holland SD, Kline WF, Matuszewski BK, Freeman A, Quan H, Lasseter KC, Mucklow JC, Porras AG. Studies of the oral bioavailability of alendronate. Clin Pharmacol Ther. 1995;58(3):288–98.CrossRefPubMed Gertz BJ, Holland SD, Kline WF, Matuszewski BK, Freeman A, Quan H, Lasseter KC, Mucklow JC, Porras AG. Studies of the oral bioavailability of alendronate. Clin Pharmacol Ther. 1995;58(3):288–98.CrossRefPubMed
46.
go back to reference Abrahamsen B, Eiken P, Eastell R. Proton pump inhibitor use and the antifracture efficacy of alendronate. Arch Intern Med. 2011;171(11):998–1004.PubMed Abrahamsen B, Eiken P, Eastell R. Proton pump inhibitor use and the antifracture efficacy of alendronate. Arch Intern Med. 2011;171(11):998–1004.PubMed
47.
go back to reference Roux C, Goldstein JL, Zhou X, Klemes A, Lindsay R. Vertebral fracture efficacy during risedronate therapy in patients using proton pump inhibitors. Osteoporos Int. 2012;23(1):277–84.CrossRefPubMed Roux C, Goldstein JL, Zhou X, Klemes A, Lindsay R. Vertebral fracture efficacy during risedronate therapy in patients using proton pump inhibitors. Osteoporos Int. 2012;23(1):277–84.CrossRefPubMed
48.
go back to reference Ziller V, Kostev K, Kyvernitakis I, Boeckhoff J, Hadji P. Persistence and compliance of medications used in the treatment of osteoporosis—analysis using a large scale, representative, longitudinal German database. Int J Clin Pharmacol Ther. 2012;50(5):315–22.CrossRefPubMed Ziller V, Kostev K, Kyvernitakis I, Boeckhoff J, Hadji P. Persistence and compliance of medications used in the treatment of osteoporosis—analysis using a large scale, representative, longitudinal German database. Int J Clin Pharmacol Ther. 2012;50(5):315–22.CrossRefPubMed
49.
go back to reference Eriksen EF, Lyles KW, Colon-Emeric CS, Pieper CF, Magaziner JS, Adachi JD, Hyldstrup L, Recknor C, Nordsletten L, Lavecchia C, et al. Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture. J Bone Miner Res. 2009;24(7):1308–13.CrossRefPubMed Eriksen EF, Lyles KW, Colon-Emeric CS, Pieper CF, Magaziner JS, Adachi JD, Hyldstrup L, Recknor C, Nordsletten L, Lavecchia C, et al. Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture. J Bone Miner Res. 2009;24(7):1308–13.CrossRefPubMed
51.
go back to reference Schray D, Stumpf U, Kammerlander C, Böcker W, Neuerburg C. Diagnosis and therapy of osteoporosis in geriatric trauma patients: an update. Inn Sur Sci. 2016;1(2):65-71. Schray D, Stumpf U, Kammerlander C, Böcker W, Neuerburg C. Diagnosis and therapy of osteoporosis in geriatric trauma patients: an update. Inn Sur Sci. 2016;1(2):65-71.
Metadata
Title
Investigation and management of osteoporosis in aged trauma patients: a treatment algorithm adapted to the German guidelines for osteoporosis
Authors
Carl Neuerburg
Lena Mittlmeier
Ralf Schmidmaier
Christian Kammerlander
Wolfgang Böcker
Wolf Mutschler
Ulla Stumpf
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2017
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/s13018-017-0585-0

Other articles of this Issue 1/2017

Journal of Orthopaedic Surgery and Research 1/2017 Go to the issue