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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2017 | Research article

Correlation between change in muscle excursion and collagen content after tendon rupture and delayed repair

Authors: Il-Hyun Koh, Ho-Jung Kang, Won-Taek Oh, Jung-Jun Hong, Yun-Rak Choi

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2017

Abstract

Background

The objectives of the present study were to compare changes in muscle excursion, total collagen, and collagen subtypes after tenotomy over time and after delayed tendon repair.

Methods

Tenotomy on the extensor digitorum tendon of the right second toes of 48 New Zealand White rabbits was performed; toes on the left leg were used as controls. Passive muscle excursion, total collagen content, and type I, III, and IV collagen contents were measured at 1, 2, 4, and 6 weeks after tenotomy. Next, passive muscle excursion and total collagen content were measured at 8 weeks after delayed tendon repair at 1, 2, 4, and 6 weeks after a tenotomy.

Results

Passive muscle excursion decreased sequentially over time after tenotomy. Meanwhile, total collagen increased over time. These changes were significant after 4 weeks of injury. Type I collagen significantly increased, type III collagen significantly decreased, and type IV collagen had no significant change over time. Passive muscle excursion was negatively correlated with total collagen and type I collagen after tenotomy at each time point after tenotomy (p < 0.05). After tendon repair, increases in total collagen content after tenotomy were not reversed, despite early repairs at 1 and 2 weeks after tenotomy.

Conclusions

Increases in type I collagen were found to be associated with decreased excursion after tendon rupture. The increase in collagen that was observed after tenotomy was not reversed by repair within 8 weeks.

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Title: Correlation between change in muscle excursion and collagen content after tendon rupture and delayed repair
Authors: Il-Hyun Koh
Ho-Jung Kang
Won-Taek Oh
Jung-Jun Hong
Yun-Rak Choi
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2017
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-017-0518-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Correlation between change in muscle excursion and collagen content after tendon rupture and delayed repair

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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