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Published in: Radiation Oncology 1/2018

Open Access 01-12-2018 | Review

PSMA-PET based radiotherapy: a review of initial experiences, survey on current practice and future perspectives

Authors: Sebastian Zschaeck, Fabian Lohaus, Marcus Beck, Gregor Habl, Stephanie Kroeze, Constantinos Zamboglou, Stefan Alexander Koerber, Jürgen Debus, Tobias Hölscher, Peter Wust, Ute Ganswindt, Alexander D. J. Baur, Klaus Zöphel, Nikola Cihoric, Matthias Guckenberger, Stephanie E. Combs, Anca Ligia Grosu, Pirus Ghadjar, Claus Belka

Published in: Radiation Oncology | Issue 1/2018

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Abstract

68Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative intended therapy. Owed to the novelty of the PSMA-targeting tracers, clinical evidence on the value of PSMA-PET is moderate but rapidly increasing. State of the art imaging is pivotal for radiotherapy treatment planning as it may affect dose prescription, target delineation and use of concomitant therapy.
This review summarizes the evidence on PSMA-PET imaging from a radiation oncologist’s point of view. Additionally a short survey containing twelve examples of patients and 6 additional questions was performed in seven mayor academic centers with experience in PSMA ligand imaging and the findings are reported here.
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Literature
5.
8.
9.
17.
go back to reference van Leeuwen PJ, Emmett L, Ho B, Delprado W, Ting F, Nguyen Q, et al. Prospective evaluation of 68Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography for preoperative lymph node staging in prostate cancer. BJU Int. 2017;119:209–15. https://doi.org/10.1111/bju.13540.CrossRefPubMed van Leeuwen PJ, Emmett L, Ho B, Delprado W, Ting F, Nguyen Q, et al. Prospective evaluation of 68Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography for preoperative lymph node staging in prostate cancer. BJU Int. 2017;119:209–15. https://​doi.​org/​10.​1111/​bju.​13540.CrossRefPubMed
19.
26.
go back to reference Rao BR, Slotman BJ, Geldof AA, Perez CA. Radiation sensitivity of Copenhagen rat prostatic carcinoma (R3327-AT and R3327-MATLyLu). Int J Radiat Oncol Biol Phys. 1991;20:981–5.CrossRefPubMed Rao BR, Slotman BJ, Geldof AA, Perez CA. Radiation sensitivity of Copenhagen rat prostatic carcinoma (R3327-AT and R3327-MATLyLu). Int J Radiat Oncol Biol Phys. 1991;20:981–5.CrossRefPubMed
33.
44.
go back to reference Thomas L, Balmus C, Ahmadzadehfar H, Essler M, Strunk H, Bundschuh RA. Assessment of bone metastases in patients with prostate Cancer-a comparison between (99m)Tc-bone-scintigraphy and [(68)Ga]Ga-PSMA PET/CT. Pharmaceuticals (Basel). 2017;10 https://doi.org/10.3390/ph10030068. Thomas L, Balmus C, Ahmadzadehfar H, Essler M, Strunk H, Bundschuh RA. Assessment of bone metastases in patients with prostate Cancer-a comparison between (99m)Tc-bone-scintigraphy and [(68)Ga]Ga-PSMA PET/CT. Pharmaceuticals (Basel). 2017;10 https://​doi.​org/​10.​3390/​ph10030068.
50.
go back to reference Rauscher I, Düwel C, Haller B, Rischpler C, Heck MM, Gschwend JE, et al. Efficacy, predictive factors, and prediction nomograms for 68Ga-labeled prostate-specific membrane antigen-ligand positron-emission tomography/computed tomography in early biochemical recurrent prostate Cancer after radical prostatectomy. Eur Urol. 2018;73:656–61. https://doi.org/10.1016/j.eururo.2018.01.006.CrossRefPubMed Rauscher I, Düwel C, Haller B, Rischpler C, Heck MM, Gschwend JE, et al. Efficacy, predictive factors, and prediction nomograms for 68Ga-labeled prostate-specific membrane antigen-ligand positron-emission tomography/computed tomography in early biochemical recurrent prostate Cancer after radical prostatectomy. Eur Urol. 2018;73:656–61. https://​doi.​org/​10.​1016/​j.​eururo.​2018.​01.​006.CrossRefPubMed
53.
58.
go back to reference Emmett L, Van Leeuwen P, Nandurkar R, Scheltema MJ, Cusick T, Hruby G, et al. Treatment outcomes from (68)GaPSMA PET CT informed salvage radiation treatment in men with rising PSA following radical prostatectomy: prognostic value of a negative PSMA PET. J Nucl Med. 2017; https://doi.org/10.2967/jnumed.117.196683. Emmett L, Van Leeuwen P, Nandurkar R, Scheltema MJ, Cusick T, Hruby G, et al. Treatment outcomes from (68)GaPSMA PET CT informed salvage radiation treatment in men with rising PSA following radical prostatectomy: prognostic value of a negative PSMA PET. J Nucl Med. 2017; https://​doi.​org/​10.​2967/​jnumed.​117.​196683.
64.
go back to reference Craft N, Chhor C, Tran C, Belldegrun A, DeKernion J, Witte ON, et al. Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process. Cancer Res. 1999;59:5030–6.PubMed Craft N, Chhor C, Tran C, Belldegrun A, DeKernion J, Witte ON, et al. Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process. Cancer Res. 1999;59:5030–6.PubMed
68.
go back to reference Guler OC, Engels B, Onal C, Everaert H, Van den Begin R, Gevaert T, et al. The feasibility of prostate-specific membrane antigen positron emission tomography(PSMA PET/CT)-guided radiotherapy in oligometastatic prostate cancer patients. Clin Transl Oncol. 2017; https://doi.org/10.1007/s12094-017-1736-9. Guler OC, Engels B, Onal C, Everaert H, Van den Begin R, Gevaert T, et al. The feasibility of prostate-specific membrane antigen positron emission tomography(PSMA PET/CT)-guided radiotherapy in oligometastatic prostate cancer patients. Clin Transl Oncol. 2017; https://​doi.​org/​10.​1007/​s12094-017-1736-9.
Metadata
Title
PSMA-PET based radiotherapy: a review of initial experiences, survey on current practice and future perspectives
Authors
Sebastian Zschaeck
Fabian Lohaus
Marcus Beck
Gregor Habl
Stephanie Kroeze
Constantinos Zamboglou
Stefan Alexander Koerber
Jürgen Debus
Tobias Hölscher
Peter Wust
Ute Ganswindt
Alexander D. J. Baur
Klaus Zöphel
Nikola Cihoric
Matthias Guckenberger
Stephanie E. Combs
Anca Ligia Grosu
Pirus Ghadjar
Claus Belka
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2018
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-018-1047-5

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