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Open Access 01-12-2018 | Research

Side effects of CT-guided implantation of ¹²⁵I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template

Authors: Yuliang Jiang, Zhe Ji, Fuxin Guo, Ran Peng, Haitao Sun, Jinghong Fan, Shuhua Wei, Weiyan Li, Kai Liu, Jinghua Lei, Junjie Wang

Published in: Radiation Oncology | Issue 1/2018

Abstract

Background

For the recurrence of head and neck cancer after operation and radiotherapy, the local control of radioactive seed implantation is good, and it has a certain palliative effect. This study aims to investigate the acute and late side effects of a three-dimentional printing non co-planar template (3D–PNCT) for computed tomography (CT)-guided radioactive ¹²⁵I seed (RIS) implantation in recurrent cancer of the head and neck.

Methods

Between January 2016 and December 2016, forty-two patients with local recurrent malignant tumors of the head and neck received 3D–PNCT-assisted RIS implantation. The prescribed dose was 110–160 Gy. Preoperative planning design, production of individual guide plates, RIS implantation, postoperative dose evaluation, and follow-up were completed for all patients. Side effects in the skin, mucous membranes, blood and spinal cord were evaluated.

Results

All patients underwent surgery successfully. Duration of follow-up was 4–14 (median, of 8.5) months. The activity of a single RIS was 0.34–0.7 (median, 0.6) mCi. The number of RIS was 10–126 (median, 34). The number of implantation needles was 4–31 (median, 11). The mean D2cc (dose to the most exposed 2-cc volume) and D0.1cc (dose to the most exposed 0.1-cc volume) of the skin were 24.9 (7.1–85.5) and 47.5 (9.4–167.2), respectively, whereas those of the spinal cord were 8.4 (4.5–33.3) and 14.2 (13.6–63.0), mucosa were 35.1 (4.2–82.8) and 87.0 (6.6–214.1), parotid glands were 16.2 (12.8–19.7) and 29.8 (26.1–33.4) and those of the trachea were 17.9 (2.5–45.9) and 32.7 (3.9–83.9), respectively. No case had an acute reaction of grade ≥ 3. Three cases had a grade-1 skin reaction. Blood toxicity did not occur, nor spinal-cord injury. Xerostomia was not aggravated than that of before brachytherapy. One case had a grade-3 nerve response.

Conclusions

3D–PNCT-assisted RIS implantation can provide good accuracy for positioning. For local recurrent malignant tumor of head and neck, there were no obvious adverse reactions.

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Title: Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template
Authors: Yuliang Jiang
Zhe Ji
Fuxin Guo
Ran Peng
Haitao Sun
Jinghong Fan
Shuhua Wei
Weiyan Li
Kai Liu
Jinghua Lei
Junjie Wang
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2018
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/s13014-018-0959-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Side effects of CT-guided implantation of ¹²⁵I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

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Abstract

Background

Methods

Results

Conclusions

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