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Radiation Oncology
Published in: Radiation Oncology 1/2017

Open Access 01-12-2017 | Research

Helical tomotherapy of spinal chordomas: French Multicentric, retrospective study of a cohort of 30 cases

Authors: Maxime Bobin, Christina Zacharatou, Paul Sargos, Véronique Brouste, Albert Lisbona, Marc-André Mahé, Georges Noël, Amandine Halley, Loïc Feuvret, Louis Gras, Stéphanie Hoppe, Bénédicte Henriques de Figueiredo, Guy Kantor

Published in: Radiation Oncology | Issue 1/2017

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Abstract

Purpose

To evaluate the efficacy and toxicity of helical tomotherapy (HT) in the management of spine chordomas when proton therapy is unavailable or non-feasible.

Methods and materials

Between 2007 and 2013, 30 patients with biopsy-proven chordomas were treated by HT in five French institutions. Information regarding local control (LC), overall survival (OS), progression-free survival (PFS) and metastasis-free survival (MFS) was collected. Clinical efficacy, toxicity and treatment quality were evaluated.

Results

Two-year actuarial LC, OS, PFS and MFS were 69.9%, 96.7%, 61.2% and 76.4%, respectively. HT treatments were well tolerated and no Grade 4–5 toxicities were observed. HT permitted the delivery of a mean dose of 68 Gy while respecting organ at risk (OAR) dose constraints, in particular in the spinal cord and cauda equina.

Conclusions

This multicentric, retrospective study demonstrated the feasibility of HT in the treatment of spine chordomas, in the absence of hadron therapy.
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Metadata
Title
Helical tomotherapy of spinal chordomas: French Multicentric, retrospective study of a cohort of 30 cases
Authors
Maxime Bobin
Christina Zacharatou
Paul Sargos
Véronique Brouste
Albert Lisbona
Marc-André Mahé
Georges Noël
Amandine Halley
Loïc Feuvret
Louis Gras
Stéphanie Hoppe
Bénédicte Henriques de Figueiredo
Guy Kantor
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2017
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-017-0768-1

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