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Radiation Oncology
Published in: Radiation Oncology 1/2015

Open Access 01-12-2015 | Research

Prostate motion during radiotherapy of prostate cancer patients with and without application of a hydrogel spacer: a comparative study

Authors: Prabhjot Juneja, Andrew Kneebone, Jeremy T. Booth, David I. Thwaites, Ramandeep Kaur, Emma Colvill, Jin A. Ng, Paul J. Keall, Thomas Eade

Published in: Radiation Oncology | Issue 1/2015

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Abstract

Background and purpose

The use of a tissue expander (hydrogel) for sparing of the rectum from increased irradiation during prostate radiotherapy is becoming popular. The goal of this study is to investigate the effect of a tissue expander (hydrogel) on the intrafraction prostate motion during radiotherapy.

Methods and material

Real time prostate motion was analysed for 26 patients and 742 fractions; 12 patients with and 14 patients without hydrogel (SpaceOAR™). The intra-fraction motion was quantified and compared between the two groups.

Results

The average (±standard deviation) of the mean motion during the treatment for patients with and without hydrogel was 1.5 (±0.8 mm) and 1.1 (±0.9 mm) respectively (p < 0.05). The average time of motion >3 mm for patients with and without hydrogel was 7.7 % (±1.1 %) and 4.5 % (±0.9 %) respectively (p > 0.05). The hydrogel age, fraction number and treatment time were found to have no effect (R 2  < 0.05) on the prostate motion.

Conclusions

Differences in intrafraction motion in patients with hydrogel and without hydrogel were within measurement uncertainty (<1 mm). This result confirms that the addition of a spacer does not negate the need for intrafraction motion management if clinically indicated.
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Metadata
Title
Prostate motion during radiotherapy of prostate cancer patients with and without application of a hydrogel spacer: a comparative study
Authors
Prabhjot Juneja
Andrew Kneebone
Jeremy T. Booth
David I. Thwaites
Ramandeep Kaur
Emma Colvill
Jin A. Ng
Paul J. Keall
Thomas Eade
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2015
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-015-0526-1

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