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Open Access 01-12-2015 | Research

Comparative dosimetric findings using accelerated partial breast irradiation across five catheter subtypes

Authors: Zaker Rana, Nadim M. Nasr, Huaying Ji, Virginia Lorio, Stephanie Akbari, Molly Sebastian, Mami Martin, Robert L. Hong

Published in: Radiation Oncology | Issue 1/2015

Abstract

Purpose

Accelerated partial breast irradiation (APBI) with balloon and strut adjusted volume implants (SAVI) show promising results with excellent tumor control and minimal toxicity. Knowing the factors that contribute to a high skin dose, rib dose, and D₉₅ coverage may reduce toxicity, improve tumor control, and help properly predict patient outcomes following APBI.

Methods and materials

A retrospective analysis of 594 patients treated with brachytherapy based APBI at a single institution from May 2008 to September 2014 was grouped by applicator subtype. Patients were treated to a total of 34 Gy (3.4 Gy x 10 fractions over 5 days delivered BID) targeting a planning target volume (PTV) 1.0 cm beyond the lumpectomy cavity using a high dose rate source.

Results

SAVI devices had the lowest statistically significant values of D_maxSkin (81.00 ± 29.83), highest values of D₉₀ (101.50 ± 3.66), and D₉₅ (96.09 ± 4.55). SAVI-mini devices had the lowest statistically significant values of D_maxRib (77.66 ± 32.92) and smallest V₁₅₀ (18.01 ± 3.39). Multi-lumen balloons were able to obtain the smallest V₂₀₀ (5.89 ± 2.21). Strut-based applicators were more likely to achieve a D_maxSkin and a D_maxRib less than or equal to 100 %. The effect of PTV on V₁₅₀ showed a strong positive relationship (p < .001). PTV and D_maxSkin showed a weak negative relationship in multi-lumen applicators (p = .016) and SAVI-mini devices (p < .001). PTV and D_maxRib showed a weak negative relationship in multi-lumen applicators (p = .009), SAVI devices (p < .001), and SAVI-mini devices (p < .001).

Conclusion

PTV volume is strongly correlated with V₁₅₀ in all devices and V₂₀₀ in strut based devices. Larger PTV volumes result in greater V₁₅₀ and V₂₀₀, which could help predict potential risks for hotspots and resulting toxicities in these devices. PTV volume is also weakly negatively correlated with max skin dose and max rib dose, meaning that as the PTV volumes increase one can expect slightly smaller max skin and rib doses. Strut based applicators are significantly more effective in keeping skin and rib dose constraints under 125 and 100 % when compared to any balloon based applicator.

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Title: Comparative dosimetric findings using accelerated partial breast irradiation across five catheter subtypes
Authors: Zaker Rana
Nadim M. Nasr
Huaying Ji
Virginia Lorio
Stephanie Akbari
Molly Sebastian
Mami Martin
Robert L. Hong
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2015
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/s13014-015-0468-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Comparative dosimetric findings using accelerated partial breast irradiation across five catheter subtypes

Abstract

Purpose

Methods and materials

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods and materials

Results

Conclusion

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