Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Radiation Oncology
Published in: Radiation Oncology 1/2015

Open Access 01-12-2015 | Research

The use of positron emission tomography/computed tomography imaging in radiation therapy: a phantom study for setting internal target volume of biological target volume

Authors: Wataru Kawakami, Akihiro Takemura, Kunihiko Yokoyama, Kenichi Nakajima, Syoichi Yokoyama, Kichiro Koshida

Published in: Radiation Oncology | Issue 1/2015

Login to get access

Abstract

Background

Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is an important method for detecting tumours, planning radiotherapy treatment, and evaluating treatment responses. However, using the standardized uptake value (SUV) threshold with PET imaging may be suitable not to determine gross tumour volume but to determine biological target volume (BTV). The aim of this study was to extract internal target volume of BTV from PET images.

Methods

Three spherical densities of 18F-FDG were employed in a phantom with an air or water background with repetitive motion amplitudes of 0–30 mm. The PET data were reconstructed with attenuation correction (AC) based on CT images obtained by slow CT scanning (SCS) or helical CT scanning (HCS). The errors in measured SUVmax and volumes calculated using SUV threshold values based on SUVmax (THmax) in experiments performed with varying extents of respiratory motion and AC were analysed.

Results

A partial volume effect (PVE) was not observed in spheres with diameters of ≥ 28 mm. When calculating SUVmax and THmax, using SCS for AC yielded smaller variance than using HCS (p < 0.05). For spheres of 37- and 28-mm diameters in the phantom with either an air or water background, significant differences were observed when mean THmax of 30-, 20-, or 10-mm amplitude were compared with the stationary conditions (p < 0.05). The average THmax values for 37-mm and 28-mm spheres with an air background were 0.362 and 0.352 in non-motion, respectively, and the mean THmax values for 37-mm and 28-mm spheres with a water background were 0.404 and 0.387 in non-motion and 0.244 and 0.263 in motion, respectively. When the phantom background was air, regardless of sphere concentration or size, THmax was dependent only on motion amplitude.

Conclusions

We found that there was no PVE for spheres with ≥ 28-mm diameters, and differences between SUVmax and THmax were reduced by using SCS for AC. In the head-and-neck and the abdomen, the standard values of THmax were 0.25 and 0.40 with and without respiratory movement, respectively. In the lungs, the value of THmax became the approximate expression depending on motion amplitude.
Literature
1.
Yu H, Caldwell C, Mah K, Poon I, Balogh J, MacKenzie R. Automated radiation targeting in head-and-neck cancer using region-based texture analysis of PET and CT images. Int J Radiat Oncol Biol Phys. 2009;75:618–25.PubMedCrossRef
2.
Le Maitre A, Hatt M, Pradier O, Cheze-le Rest C, Visvikis D. Impact of the accuracy of automatic tumour functional volume delineation on radiotherapy treatment planning. Phys Med Biol. 2012;57:5381–97.PubMedCrossRef
3.
MacManus M, Nestle U, Rosenzweig KE, Carrio I, Messa C, Belohlavek O, et al. Use of PET and PET/CT for radiation therapy planning: IAEA expert report 2006–2007. Radiother Oncol. 2009;91:85–94.PubMedCrossRef
4.
Jingu K, Takeda K, Metoki T, Ogawa Y, Ariga H, Yamada S, et al. The difference between gross tumor volume and biological target volume in postoperative local recurrent rectal cancer; a preliminary study of PET/CT radiation therapy planning. J Jpn Soc Ther Radiol Oncol. 2008;20:127–31.
5.
Devic S, Tomic N, Faria S, Dean G, Lisbona R, Parker W, et al. Impact of 18FDG-PET/CT on biological target volume (BTV) definition for treatment planning for non-small cell lung cancer patients. Nucl Instrum Methods Phys Res Section A. 2007;571:89–92.CrossRef
6.
Erdi YE, Mawlawi O, Larson SM, Imbriaco M, Yeung H, Finn R, et al. Segmentation of lung lesion volume by adaptive positron emission tomography image thresholding. Cancer. 1997;80:2505–9.PubMedCrossRef
7.
Nagel CC, Bosmans G, Dekker AL, Ollers MC, De Ruysscher DK, Lambin P, et al. Phased attenuation correction in respiration correlated computed tomography/positron emitted tomography. Med Phys. 2006;33:1840–7.PubMedCrossRef
8.
Okubo M, Nishimura Y, Nakamatsu K, Okumura M, Shibata T, Kanamori S, et al. Static and moving phantom studies for radiation treatment planning in a positron emission tomography and computed tomography (PET/CT) system. Ann Nucl Med. 2008;22:579–86.PubMedCrossRef
9.
Yaremko B, Riauka T, Robinson D, Murray B, Alexander A, McEwan A, et al. Thresholding in PET images of static and moving targets. Phys Med Biol. 2005;50:5969–82.PubMedCrossRef
10.
Sakaguchi Y, Mitsumoto T, Zhang T, Mitsumoto K, Tachiya Y, Ohya N, et al. Importance of gated CT acquisition for the quantitative improvement of the gated PET/CT in moving phantom. Ann Nucl Med. 2010;24:507–14.PubMedCrossRef
11.
Toya R, Murakami R, Tashiro K, Yoshida M, Sakamoto F, Kawanaka K, et al. FDG-PET/CT-based gross tumor volume contouring for radiation therapy planning: an experimental phantom study. J Radiat Res. 2012;53:338–41.PubMedCrossRef
12.
Niyazi M, Landrock S, Elsner A, Manapov F, Hacker M, Belka C, et al. Automated biological target volume delineation for radiotherapy treatment planning using FDG-PET/CT. Radiat Oncol. 2013;8:180.PubMedCentralPubMedCrossRef
13.
Liu C, Pierce 2nd LA, Alessio AM, Kinahan PE. The impact of respiratory motion on tumor quantification and delineation in static PET/CT imaging. Phys Med Biol. 2009;54:7345–62.PubMedCentralPubMedCrossRef
14.
Geramifar P, Zafarghandi MS, Ghafarian P, Rahmim A, Ay MR. Respiratory-induced errors in tumor quantification and delineation in CT attenuation-corrected PET images: effects of tumor size, tumor location, and respiratory trace: a simulation study using the 4D XCAT phantom. Mol Imaging Biol. 2013;15:655–65.PubMedCrossRef
15.
Nehmeh SA, Erdi YE. Respiratory motion in positron emission tomography/computed tomography: a review. Semin Nucl Med. 2008;38:167–76.PubMedCrossRef
16.
Kasuya T, Tateishi U, Suzuki K, Daisaki H, Nishiyama Y, Hata M, et al. Role of respiratory-gated PET/CT for pancreatic tumors: a preliminary result. Eur J Radiol. 2013;82:69–74.PubMedCrossRef
17.
Callahan J, Kron T, Schneider-Kolsky M, Hicks RJ. The clinical significance and management of lesion motion due to respiration during PET/CT scanning. Cancer Imaging. 2011;11:224–36.PubMedCentralPubMed
18.
Park SJ, Ionascu D, Killoran J, Mamede M, Gerbaudo VH, Chin L, et al. Evaluation of the combined effects of target size, respiratory motion and background activity on 3D and 4D PET/CT images. Phys Med Biol. 2008;53:3661–79.PubMedCrossRef
19.
Didierlaurent D, Ribes S, Batatia H, Jaudet C, Dierickx LO, Zerdoud S, et al. The retrospective binning method improves the consistency of phase binning in respiratory-gated PET/CT. Phys Med Biol. 2012;57:7829–41.PubMedCrossRef
20.
Lamare F, Ledesma Carbayo MJ, Cresson T, Kontaxakis G, Santos A, Le Rest CC, et al. List-mode-based reconstruction for respiratory motion correction in PET using non-rigid body transformations. Phys Med Biol. 2007;52:5187–204.PubMedCrossRef
21.
Pevsner A, Nehmeh SA, Humm JL, Mageras GS, Erdi YE. Effect of motion on tracer activity determination in CT attenuation corrected PET images: a lung phantom study. Med Phys. 2005;32:2358–62.PubMedCrossRef
22.
Yu J, Li X, Xing L, Mu D, Fu Z, Sun X, et al. Comparison of tumor volumes as determined by pathologic examination and FDG-PET/CT images of non-small-cell lung cancer: a pilot study. Int J Radiat Oncol Biol Phys. 2009;75:1468–74.PubMedCrossRef
23.
Biehl KJ, Kong FM, Dehdashti F, Jin JY, Mutic S, Naqa EI, et al. 18F-FDG PET definition of gross tumor volume for radiotherapy of non-small cell lung cancer: is a single standardized uptake value threshold approach appropriate? J Nucl Med. 2005;61:1385–92.
24.
Paulino AC, Koshy M, Howell R, Schuster D, Davis LW. Comparison of CT- and FDG-PET- defined gross tumor volume in intensity-modulated radiotherapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009;75:1468–74.CrossRef
25.
Bassi MC, Turri L, Sacchetti G, Loi G, Cannillo B, La Mattina P, et al. FDG-PET/CT imaging for staging and target volume delineation in preoperative conformal radiotherapy of rectal cancer. Int J Radiat Oncol Biol Phys. 2008;70:1423–6.PubMedCrossRef
Metadata
Title
The use of positron emission tomography/computed tomography imaging in radiation therapy: a phantom study for setting internal target volume of biological target volume
Authors
Wataru Kawakami
Akihiro Takemura
Kunihiko Yokoyama
Kenichi Nakajima
Syoichi Yokoyama
Kichiro Koshida
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2015
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-014-0315-2

Other articles of this Issue 1/2015

Radiation Oncology 1/2015 Go to the issue

Research

Pretreatment 18 F-FDG uptake heterogeneity can predict survival in patients with locally advanced nasopharyngeal carcinoma——a retrospective study

Research

Attenuation measurements show that the presence of a TachoSil surgical patch will not compromise target irradiation in intra-operative electron radiation therapy or high-dose-rate brachytherapy

Research

Quality of life during 5 years after stereotactic radiotherapy in stage I non-small cell lung cancer

Research

Concurrent chemoradiotherapy was associated with a higher severe late toxicity rate in nasopharyngeal carcinoma patients compared with radiotherapy alone: a meta-analysis based on randomized controlled trials

Research

Effects of Radiotherapy in the treatment of multiple myeloma: a retrospective analysis of a Single Institution

Research

Prospective study of cetuximab and gemcitabine in combination with radiation therapy: feasibility and efficacy in locally advanced pancreatic head cancer