Skip to main content
Top
Published in: Implementation Science 1/2015

Open Access 01-12-2015 | Research

Using a systematic review in clinical decision making: a pilot parallel, randomized controlled trial

Authors: Laure Perrier, Nav Persaud, Kevin E. Thorpe, Sharon E. Straus

Published in: Implementation Science | Issue 1/2015

Login to get access

Abstract

Background

Evidence suggests that systematic reviews are used infrequently by physicians in clinical decision-making. One proposed solution is to create filtered resources so that information is validated and refined in order to be read quickly. Two shortened systematic review formats were developed to enhance their use in clinical decision-making.

Methods

To prepare for a full-scale trial, we conducted a pilot study to test methods and procedures in order to refine the processes. A recruitment email was sent to physicians practicing full- or part-time in family medicine or general internal medicine. The pilot study took place in an online environment and eligible physicians were randomized to one of the systematic review formats (shortened or full-length) and instructed to read the document. Participants were asked to provide the clinical bottom line and apply the information presented to a clinical scenario. Participants’ answers were evaluated independently by two investigators against “gold standard” answers prepared by an expert panel.

Results

Fifty-six clinicians completed the pilot study within a 2-month period with a response rate of 4.3 %. Agreement between investigators in assessing participants’ answers was determined by calculating a kappa statistic. Two questions were assessed separately, and a kappa statistic was calculated at 1.00 (100 % agreement) for each.

Conclusions

Agreement between investigators in assessing participants’ answers is satisfactory. Although recruitment for the pilot study was completed in a reasonable time-frame, response rates were low and will require large numbers of contacts. The results indicate that conducting a full-scale trial is feasible.

Trial registration

ClinicalTrials.gov NCT02414360.
Appendix
Available only for authorised users
Literature
2.
go back to reference De Vito C, Nobile CG, Furnari G, Pavia M, De Giusti M, Angelillo IF, et al. Physicians’ knowledge, attitudes and professional use of RCTs and meta-analyses: a cross-sectional survey. Eur J Public Health. 2009;19(3):297–302.CrossRefPubMed De Vito C, Nobile CG, Furnari G, Pavia M, De Giusti M, Angelillo IF, et al. Physicians’ knowledge, attitudes and professional use of RCTs and meta-analyses: a cross-sectional survey. Eur J Public Health. 2009;19(3):297–302.CrossRefPubMed
3.
go back to reference Laupacis A, Straus S. Systematic reviews: time to address clinical and policy relevance as well as methodological rigor. Ann Intern Med. 2007;147(4):273–4. Aug 21.CrossRefPubMed Laupacis A, Straus S. Systematic reviews: time to address clinical and policy relevance as well as methodological rigor. Ann Intern Med. 2007;147(4):273–4. Aug 21.CrossRefPubMed
4.
go back to reference Andrews JE, Pearce KA, Ireson C, Love MM. Information-seeking behaviors of practitioners in a primary care practice-based research network (PBRN). J Med Libr Assoc. 2005;93(2):206–12. Andrews JE, Pearce KA, Ireson C, Love MM. Information-seeking behaviors of practitioners in a primary care practice-based research network (PBRN). J Med Libr Assoc. 2005;93(2):206–12.
5.
go back to reference Coumou HC, Meijman FJ. How do primary care physicians seek answers to clinical questions? A literature review. J Med Libr Assoc. 2006;94:55–60.PubMedPubMedCentral Coumou HC, Meijman FJ. How do primary care physicians seek answers to clinical questions? A literature review. J Med Libr Assoc. 2006;94:55–60.PubMedPubMedCentral
6.
go back to reference D’Alessandro DM, Kreiter CD, Peterson MW. An evaluation of information seeking behaviors of general pediatricians. Pediatrics. 2004;113:64–9.CrossRefPubMed D’Alessandro DM, Kreiter CD, Peterson MW. An evaluation of information seeking behaviors of general pediatricians. Pediatrics. 2004;113:64–9.CrossRefPubMed
7.
go back to reference Ely JW, Osheroff JA, Ebell MH, Chambliss ML, Vinson DC, Stevermer JJ, et al. Obstacles to answering doctors’ questions about patient care with evidence: qualitative study. BMJ. 2002;324(7339):710. Ely JW, Osheroff JA, Ebell MH, Chambliss ML, Vinson DC, Stevermer JJ, et al. Obstacles to answering doctors’ questions about patient care with evidence: qualitative study. BMJ. 2002;324(7339):710.
8.
go back to reference Ely JW, Osheroff JA, Chambliss ML, Ebell MH, Rosenbaum ME. Answering physicians' clinical questions: obstacles and potential solutions. J Am Med Inform Assoc. 2005;12(2):217–24. Ely JW, Osheroff JA, Chambliss ML, Ebell MH, Rosenbaum ME. Answering physicians' clinical questions: obstacles and potential solutions. J Am Med Inform Assoc. 2005;12(2):217–24.
9.
go back to reference Fozi K, Teng CL, Krishnan R, Shajahan Y. A study of clinical questions in primary care. Med J Malaysia. 2000;55(4):486–92. Fozi K, Teng CL, Krishnan R, Shajahan Y. A study of clinical questions in primary care. Med J Malaysia. 2000;55(4):486–92.
10.
go back to reference Grandage KK, Slawson DC, Shaughnessy AF. When less is more: a practical approach to searching for evidence-based answers. J Med Libr Assoc. 2002;90:298–304.PubMedPubMedCentral Grandage KK, Slawson DC, Shaughnessy AF. When less is more: a practical approach to searching for evidence-based answers. J Med Libr Assoc. 2002;90:298–304.PubMedPubMedCentral
11.
go back to reference Jones TH, Hanney S, Buxton MJ. The role of the national general medical journal: surveys of which journals UK clinicians read to inform their clinical practice. Med Clin (Barc). 2008;131(5 Suppl):30–5.CrossRef Jones TH, Hanney S, Buxton MJ. The role of the national general medical journal: surveys of which journals UK clinicians read to inform their clinical practice. Med Clin (Barc). 2008;131(5 Suppl):30–5.CrossRef
12.
go back to reference Prorok JC, Iserman EC, Wilczynski NL, Haynes RB. The quality, breadth, and timeliness of content updating vary substantially for 10 online medical texts: an analytic survey. J Clin Epidemiol. 2012;65:1289–95.CrossRefPubMed Prorok JC, Iserman EC, Wilczynski NL, Haynes RB. The quality, breadth, and timeliness of content updating vary substantially for 10 online medical texts: an analytic survey. J Clin Epidemiol. 2012;65:1289–95.CrossRefPubMed
13.
go back to reference Perrier L, Mrklas K, Shepperd S, Dobbins M, McKibbon KA, Straus SE. Interventions encouraging the use of systematic reviews in clinical decision-making: a systematic review. J Gen Intern Med. 2011;26(4):419–26.CrossRefPubMed Perrier L, Mrklas K, Shepperd S, Dobbins M, McKibbon KA, Straus SE. Interventions encouraging the use of systematic reviews in clinical decision-making: a systematic review. J Gen Intern Med. 2011;26(4):419–26.CrossRefPubMed
14.
go back to reference Rosenbaum SE, Glenton C, Oxman AD. Summary-of-findings tables in Cochrane reviews improved understanding and rapid retrieval of key information. J Clin Epidemiol. 2010;63(6):620–6.CrossRefPubMed Rosenbaum SE, Glenton C, Oxman AD. Summary-of-findings tables in Cochrane reviews improved understanding and rapid retrieval of key information. J Clin Epidemiol. 2010;63(6):620–6.CrossRefPubMed
15.
go back to reference Rosenbaum SE, Glenton C, Nylund HK, Oxman AD. User testing and stakeholder feedback contributed to the development of understandable and useful summary of findings tables for Cochrane reviews. J Clin Epidemiol. 2010;63(6):607–19.CrossRefPubMed Rosenbaum SE, Glenton C, Nylund HK, Oxman AD. User testing and stakeholder feedback contributed to the development of understandable and useful summary of findings tables for Cochrane reviews. J Clin Epidemiol. 2010;63(6):607–19.CrossRefPubMed
16.
go back to reference Perrier L, Persaud N, Ko A, Kastner M, Grimshaw J, McKibbon KA, et al. Development of two shortened systematic review formats for clinicians. Implement Sci. 2013;8:68. Jun 14.CrossRefPubMedPubMedCentral Perrier L, Persaud N, Ko A, Kastner M, Grimshaw J, McKibbon KA, et al. Development of two shortened systematic review formats for clinicians. Implement Sci. 2013;8:68. Jun 14.CrossRefPubMedPubMedCentral
17.
go back to reference Perrier L, Kealey MR, Straus SE. An iterative evaluation of two shortened systematic review formats for clinicians: a focus group study. J Am Med Inform Assoc. 2014;21(e2):e341–6.CrossRefPubMedPubMedCentral Perrier L, Kealey MR, Straus SE. An iterative evaluation of two shortened systematic review formats for clinicians: a focus group study. J Am Med Inform Assoc. 2014;21(e2):e341–6.CrossRefPubMedPubMedCentral
18.
go back to reference Perrier L, Kealey MR, Straus SE. A usability study of two formats of a shortened systematic review for clinicians. BMJ Open. 2014;4(12):e005919. Dec 23.CrossRefPubMedPubMedCentral Perrier L, Kealey MR, Straus SE. A usability study of two formats of a shortened systematic review for clinicians. BMJ Open. 2014;4(12):e005919. Dec 23.CrossRefPubMedPubMedCentral
19.
go back to reference Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios LP, et al. A tutorial on pilot studies: the what, why and how. BMC Med Res Methodol. 2010;10:1. Jan 6.CrossRefPubMedPubMedCentral Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios LP, et al. A tutorial on pilot studies: the what, why and how. BMC Med Res Methodol. 2010;10:1. Jan 6.CrossRefPubMedPubMedCentral
20.
go back to reference Campbell M, Fitzpatrick R, Haines A, Kinmonth AL, Sandercock P, Spiegelhalter D, et al. Framework for the design and evaluation of complex interventions to improve health. BMJ. 2000;321:694–6.CrossRefPubMedPubMedCentral Campbell M, Fitzpatrick R, Haines A, Kinmonth AL, Sandercock P, Spiegelhalter D, et al. Framework for the design and evaluation of complex interventions to improve health. BMJ. 2000;321:694–6.CrossRefPubMedPubMedCentral
21.
go back to reference Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, Petticrew M. Medical Research Council Guidance. Developing and evaluating complex interventions: the new Medical Research Council guidance. BMJ. 2008;337:a1655. Sep 29.CrossRefPubMedPubMedCentral Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, Petticrew M. Medical Research Council Guidance. Developing and evaluating complex interventions: the new Medical Research Council guidance. BMJ. 2008;337:a1655. Sep 29.CrossRefPubMedPubMedCentral
22.
go back to reference Orwin RG. Evaluating coding decisions. In: Cooper H, Hedges LV, editors. The handbook of research synthesis. New York (NY): Russell Sage; 1994. Orwin RG. Evaluating coding decisions. In: Cooper H, Hedges LV, editors. The handbook of research synthesis. New York (NY): Russell Sage; 1994.
23.
go back to reference Moher D, Schulz KF, Altman DG. CONSORT Group (Consolidated Standards of Reporting Trials): The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. J Am Podiatr Med Assoc. 2001;91:437–42.CrossRefPubMed Moher D, Schulz KF, Altman DG. CONSORT Group (Consolidated Standards of Reporting Trials): The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. J Am Podiatr Med Assoc. 2001;91:437–42.CrossRefPubMed
26.
go back to reference R Development Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. Available at: http://www.r-project.org. Accessed July 4, 2015. R Development Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. Available at: http://​www.​r-project.​org. Accessed July 4, 2015.
27.
go back to reference Cocks K, Torgenson DJ. Sample size calculations for pilot randomized trials: a confidence interval approach. J Clin Epidemiol. 2013;66:197–201.CrossRefPubMed Cocks K, Torgenson DJ. Sample size calculations for pilot randomized trials: a confidence interval approach. J Clin Epidemiol. 2013;66:197–201.CrossRefPubMed
28.
go back to reference McDonald JW, Mahon J, Zarnke K, Feagan B, Simms L, Tucker W. A randomized survey of the preference of gastroenterologists for a Cochrane review versus a traditional narrative review. Can J Gastroenterol. 2002;16(1):17–21.CrossRefPubMed McDonald JW, Mahon J, Zarnke K, Feagan B, Simms L, Tucker W. A randomized survey of the preference of gastroenterologists for a Cochrane review versus a traditional narrative review. Can J Gastroenterol. 2002;16(1):17–21.CrossRefPubMed
29.
go back to reference VanGeest JB, Johnson TP, Welch VL. Methodologies for improving response rates in surveys of physicians: a systematic review. Eval Health Prof. 2007;30(4):303–21.CrossRefPubMed VanGeest JB, Johnson TP, Welch VL. Methodologies for improving response rates in surveys of physicians: a systematic review. Eval Health Prof. 2007;30(4):303–21.CrossRefPubMed
Metadata
Title
Using a systematic review in clinical decision making: a pilot parallel, randomized controlled trial
Authors
Laure Perrier
Nav Persaud
Kevin E. Thorpe
Sharon E. Straus
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Implementation Science / Issue 1/2015
Electronic ISSN: 1748-5908
DOI
https://doi.org/10.1186/s13012-015-0303-4

Other articles of this Issue 1/2015

Implementation Science 1/2015 Go to the issue