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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2019

Open Access 01-12-2019 | Phlebography | Case Report

Extremely rare case of intravascular solitary fibrous tumour in the inferior vena cava with review of the literature

Authors: Jingyuan Fan, Jinfeng Qiu, Qingjun Wei

Published in: Diagnostic Pathology | Issue 1/2019

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Abstract

Background

Solitary fibrous tumour (SFT) is a mesenchymal tumour of fibroblastic type, and it develops in almost any part of the human body. However, according to previous studies, the occurrence of intravascular SFTs is extremely rare.

Case presentation

We reported a case of intravascular SFT in a 67-year-old woman who has been experiencing swelling and pain in the right leg for 2 months. Computed tomography venography scan revealed a well-defined mass obstructing the inferior vena cava (IVC). Surgical resection was performed, and histopathologic and immunohistochemical results were consistent with SFT. Further, next-generation sequencing (NGS) analysis was performed, and results revealed two tumour-related gene mutations (deletion of PMS2 and variation of ESR1 [L536P]). The patient did not receive any adjuvant therapy, and no signs of tumour progression were observed during the 6-month follow-up.

Conclusion

To the best of our knowledge, this study first presented about SFT arising from the IVC and carried out an NGS analysis to validate the molecular mechanism of such condition.
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Metadata
Title
Extremely rare case of intravascular solitary fibrous tumour in the inferior vena cava with review of the literature
Authors
Jingyuan Fan
Jinfeng Qiu
Qingjun Wei
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Phlebography
Published in
Diagnostic Pathology / Issue 1/2019
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-019-0862-9

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