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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2019

Open Access 01-12-2019 | Case Report

Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report

Authors: Mitsumasa Osakabe, Chie Sato, Masamichi Suzuki, Ryo Sugimoto, Yasuko Fujita, Noriyuki Uesugi, Kazuyuki Ishida, Hiroaki Itamochi, Tsukasa Baba, Tamotsu Sugai

Published in: Diagnostic Pathology | Issue 1/2019

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Abstract

Background

Ovarian Sertoli-Leydig cell tumors (SLCTs) with androgenic manifestations harbor DICER1 mutations in 30–60% of cases. Ovarian SLCTs without DICER1 hotspot mutations have been reported to exhibit elderly onset and no androgenic manifestations. We present the first case of a primary mesenteric SLCT without DICER1 hotspot mutation.

Case presentation

An 84-year-old woman presented with a 75-mm mesenteric solid tumor. She presented no androgenic or estrogenic manifestations. She underwent ileocecal resection. Histologically, her mesenteric tumor showed histopathological features that resembled moderately differentiated SLCT. Moreover, DICER1 hotspot mutation was not detected.

Conclusions

We described the first case of heterotopic primary mesenteric SLCT without DICER1 hotspot mutation.
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Metadata
Title
Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report
Authors
Mitsumasa Osakabe
Chie Sato
Masamichi Suzuki
Ryo Sugimoto
Yasuko Fujita
Noriyuki Uesugi
Kazuyuki Ishida
Hiroaki Itamochi
Tsukasa Baba
Tamotsu Sugai
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2019
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-019-0805-5

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