Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Diagnostic Pathology
Published in: Diagnostic Pathology 1/2019

Open Access 01-12-2019 | Research

Pathological diagnosis of thyroid nodules based on core needle biopsies: comparative study between core needle biopsies and resected specimens in 578 cases

Authors: Yan Xiong, Limin Yan, Lin Nong, Yalin Zheng, Ting Li

Published in: Diagnostic Pathology | Issue 1/2019

Login to get access

Abstract

Background

Pathological diagnosis based on core needle biopsy (CNB) should be different from a resected specimen because it is difficult to apply the histological criteria established for resected specimens to CNB due to sampling limitations. A pathological classification for thyroid nodule on CNB was first proposed by the Korean Group in 2015. The objective of this study was to test the reliability and clinical value of this proposal.

Methods

According to the Korean proposal, the CNB diagnoses were categorized into unsatisfactory, benign, indeterminate, follicular neoplasm, suspicious for malignancy and malignant. A comparative study between the diagnoses of CNB and resected specimens was performed.

Results

The consistency was moderate (κ = 0.448). Combined indeterminate, suspicious for malignancy and malignant into a single group collectively referred to as “malignant” with the remaining merged into “others”, CNB demonstrated a 95.93% sensitivity, 97.30% specificity, 62.07% accuracy, 99.81% positive predictive value (PPV) and 62.07% negative predictive value (NPV) for preoperative malignancy evaluation.

Conclusions

The Korean proposal for pathological classification of thyroid nodules on CNB is objective, operable and highly valuable.
Literature
1.
Teng W, Liu Y, Gao M, Huang G, Wu Y, Zhao J, et al. The Chinese society of endocrinology guidelines taskforce on thyroid nodules and differentiated thyroid cancer. Chin J Endocrinol Metab. 2012;28(10):779–97.
2.
Pitman MB, Abele J, Ali SZ, Duick D, Elsheikh TM, Jeffrey RB, et al. Techniques for thyroid FNA: a synopsis of the National Cancer Institute thyroid fine-needle aspiration state of the science conference. Diagn Cytopathol 2008;36(6):407–424. PubMed PMID: 18478608.
3.
Jung CK, Hong S, Bychkov A, Kakudo K. The use of fine-needle aspiration (FNA) cytology in patients with thyroid nodules in Asia: a brief overview of studies from the working Group of Asian Thyroid FNA cytology. J Pathol Transl Med 2017;51(6):571–578. PubMed PMID: 29073758. Pubmed Central PMCID: 5700887.
4.
Choe J, Baek JH, Park HS, Choi YJ, Lee JH. Core needle biopsy of thyroid nodules: outcomes and safety from a large single-center single-operator study. Acta Radiol 2018;59(8):924–931. PubMed PMID: 29137498.
5.
Ha EJ, Baek JH, Lee JH, Kim JK, Choi YJ, Sung TY, et al. Complications following US-guided core-needle biopsy for thyroid lesions: a retrospective study of 6,169 consecutive patients with 6,687 thyroid nodules. Eur Radiol 2017;27(3):1186–1194. PubMed PMID: 27311538.
6.
Jeong EJ, Chung SR, Baek JH, Choi YJ, Kim JK, Lee JH. A comparison of ultrasound-guided fine needle aspiration versus Core needle biopsy for thyroid nodules: pain, tolerability, and complications. Endocrinol Metab 2018;33(1):114–120. PubMed PMID: 29589393. Pubmed Central PMCID: 5874187.
7.
Baloch ZW, Cibas ES, Clark DP, Layfield LJ, Ljung BM, Pitman MB, et al. The National Cancer Institute thyroid fine needle aspiration state of the science conference: a summation. CytoJournal 2008;5:6. PubMed PMID: 18394201. Pubmed Central PMCID: 2365970.
8.
Gharib H, Papini E, Garber JR, Duick DS, Harrell RM, Hegedus L, et al. American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and Management of Thyroid Nodules--2016 update. Endocr Pract 2016;22(5):622–639. PubMed PMID: 27167915.
9.
Na DG, Baek JH, Jung SL, Kim JH, Sung JY, Kim KS, et al. Core needle biopsy of the thyroid: 2016 consensus statement and recommendations from Korean Society of Thyroid Radiology. Korean J Radiol 2017;18(1):217–237. PubMed PMID: 28096731. Pubmed Central PMCID: 5240493.
10.
Trimboli P, Nasrollah N, Guidobaldi L, Taccogna S, Cicciarella Modica DD, Amendola S, et al. The use of core needle biopsy as first-line in diagnosis of thyroid nodules reduces false negative and inconclusive data reported by fine-needle aspiration. World J Surg Oncol 2014;12:61. PubMed PMID: 24661377. Pubmed Central PMCID: 3987871.
11.
Suh CH, Baek JH, Lee JH, Choi YJ, Kim JK, Sung TY, et al. The role of Core-needle biopsy as a first-line diagnostic tool for initially detected thyroid nodules. Thyroid 2016;26(3):395–403. PubMed PMID: 26651390.
12.
Kim HC, Kim YJ, Han HY, Yi JM, Baek JH, Park SY, et al. First-line use of Core needle biopsy for high-yield preliminary diagnosis of thyroid nodules. AJNR Am J Neuroradiol 2017;38(2):357–363. PubMed PMID: 27932508.
13.
Jung CK, Min HS, Park HJ, Song DE, Kim JH, Park SY, et al. Pathology reporting of thyroid Core needle biopsy: a proposal of the Korean endocrine pathology thyroid Core needle biopsy study group. J Pathol Transl Med 2015;49(4):288–299. PubMed PMID: 26081825. Pubmed Central PMCID: 4508566.
14.
Nasrollah N, Trimboli P, Rossi F, Amendola S, Guidobaldi L, Ventura C, et al. Patient's comfort with and tolerability of thyroid core needle biopsy. Endocrine 2014;45(1):79–83. PubMed PMID: 23673868.
15.
Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977;33(1):159–174. PubMed PMID: 843571.
16.
Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG. WHO classification of tumours of the lung, pleura, thymus and heart. 4th Edition ed. Lyon: International Agency for Research on Cancer (IARC); 2015. 18 p.
17.
Baier ND, Hahn PF, Gervais DA, Samir A, Halpern EF, Mueller PR, et al. Fine-needle aspiration biopsy of thyroid nodules: experience in a cohort of 944 patients. AJR Am J Roentgenol 2009;193(4):1175–1179. PubMed PMID: 19770344.
18.
Zhong LC, Lu F, Ma F, Xu HX, Li DD, Guo LH, et al. Ultrasound-guided fine-needle aspiration of thyroid nodules: does the size limit its efficiency? Int J Clin Exp Pathol 2015;8(3):3155–3159. PubMed PMID: 26045833. Pubmed Central PMCID: 4440142.
19.
Seningen JL, Nassar A, Henry MR. Correlation of thyroid nodule fine-needle aspiration cytology with corresponding histology at Mayo Clinic, 2001-2007: an institutional experience of 1,945 cases. Diagn Cytopathol 2012;40 Suppl 1:E27–E32. PubMed PMID: 22619156.
Metadata
Title
Pathological diagnosis of thyroid nodules based on core needle biopsies: comparative study between core needle biopsies and resected specimens in 578 cases
Authors
Yan Xiong
Limin Yan
Lin Nong
Yalin Zheng
Ting Li
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2019
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-019-0786-4

Other articles of this Issue 1/2019

Diagnostic Pathology 1/2019 Go to the issue

Review

Applications of molecular neuro-oncology - a review of diffuse glioma integrated diagnosis and emerging molecular entities

Case Report

Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features – case report and literature review

Research

Diagnostic terminology used to describe atypia on breast core needle biopsy: correlation with excision and upgrade rates

Research

Clinicopathologic and microenvironmental analysis of primary cutaneous CD30-positive lymphoproliferative disorders: a 26 year experience from an academic medical center in Brazil

Research

RRBP1 overexpression is associated with progression and prognosis in endometrial endometrioid adenocarcinoma

Research

Serum expression of selected miRNAs in patients with laryngeal squamous cell carcinoma (LSCC)