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Diagnostic Pathology

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Open Access 01-12-2017 | Case Report

Composite neuroendocrine tumor and adenocarcinoma of the rectum

Authors: Hiromi Kanno-Okada, Tomoko Mitsuhashi, Katsuhiro Mabe, Tadakazu Shimoda, Yoshihiro Matsuno

Published in: Diagnostic Pathology | Issue 1/2017

Abstract

Background

Although adenocarcinomas showing neuroendocrine differentiation or those mixed with high-grade neuroendocrine carcinoma (NEC) are sometimes encountered, composite tumors comprising neuroendocrine tumor (NET) Grade 1 and adenocarcinoma are exceedingly rare.

Case presentation

A 64-year-old male presented after testing positive for fecal occult blood at a medical check-up. A biopsy demonstrated the presence of a NET and endoscopic submucosal dissection was undertaken. Histologic examination revealed that a well differentiated tubular adenocarcinoma was present in addition to the NET. Furthermore, histological transition between the two tumors was evident. Accordingly, this case was considered to be a composite tumor comprising NET and adenocarcinoma.

Conclusion

Composite tumors consisting of NET Grade 1 and adenocarcinoma are exceedingly rare, and only a few examples have been reported hitherto.

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Title: Composite neuroendocrine tumor and adenocarcinoma of the rectum
Authors: Hiromi Kanno-Okada
Tomoko Mitsuhashi
Katsuhiro Mabe
Tadakazu Shimoda
Yoshihiro Matsuno
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2017
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-017-0674-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Composite neuroendocrine tumor and adenocarcinoma of the rectum

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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