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Diagnostic Pathology

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Open Access 01-12-2017 | Case Report

Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review

Authors: Hui-ming Sun, Fei Chen, Hong-lin Yin, Xiao-yong Xu, Hong-bing Liu, Bei-lei Zhao

Published in: Diagnostic Pathology | Issue 1/2017

Abstract

Background

Metastatic pulmonary calcification (MPC) is rarely reported in primary hyperparathyroidism, especially MPC develops quickly. We report such a case here with a literature review.

Case presentation

A 41-year-old woman presented with cough and dyspnea. Data from clinical, radiological, pathological, technetium (^99mTc)-methylene diphosphonate (MDP) bone scintillation imaging, and ^99mTc-methoxy isobutyl isonitrile (MIBI) thyroid imaging were studied. ^99mTc-MIBI thyroid imaging indicated hyperparathyroidism. Chest computed tomography (CT) scans showed rapidly progressive bilateral pulmonary multiple high-density shadows with mass consolidation and exudation in only five days. ^99mTc-MDP bone scintillation imaging indicated bilateral pulmonary calcifications. CT-guided lung biopsy showed multifocal irregularities of calcium deposition and calcified bodies in the pulmonary interstitium. The patient showed gradually clinical and radiological improvement after surgical removal of the parathyroid adenoma.

Conclusion

Rapidly progressive MPC tends to be misdiagnosed as many primary pulmonary diseases. ^99mTc-MDP bone scintillation imaging and pulmonary biopsy could be performed to differentiate metastatic pulmonary calcification from other diseases. Surgical resection of the parathyroid gland is helpful for treatment of MPC in patients with primary hyperparathyroidism and is regularly recommended.

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Title: Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review
Authors: Hui-ming Sun
Fei Chen
Hong-lin Yin
Xiao-yong Xu
Hong-bing Liu
Bei-lei Zhao
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2017
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-017-0628-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review

Abstract

Background

Case presentation

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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