Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Diagnostic Pathology
Published in: Diagnostic Pathology 1/2016

Open Access 01-12-2016 | Case Report

Case Report: Epstein-Barr-Virus negative diffuse large B-cell lymphoma detected in a peri-prosthetic membrane 

Authors: Sandra Sunitsch, Magdalena Gilg, Karl Kashofer, Andreas Leithner, Bernadette Liegl-Atzwanger, Christine Beham-Schmid

Published in: Diagnostic Pathology | Issue 1/2016

Login to get access

Abstract

Background

Primary bone lymphomas (PBL) are extremely rare malignant neoplasms. The most commonly described subtype of PBL is diffuse large B-cell lymphoma (DLBCL). DLBCL within peri-prosthetic membrane of a joint is exceedingly rare. To the best of our knowledge this case is the second reported Epstein-Bar-Virus (EBV) negative DLBCL in a peri-prosthetic membrane in the literature.

Case presentation

We report an 80 year old female patient who developed a DLBCL with chronic inflammation in association to a metallic implant in the left knee. This lymphoma in contrast to the usually described DLBCL in the peri-prosthetic membrane was EBV negative by EBER in situ hybridization as well as by polymerase chain reaction (PCR).

Conclusion

This report challenges the concept of DLBCL associated with chronic inflammation and raises the question of other pathogenetic factors involved in the pathogenesis of this rare disease.
Literature
1.
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue, 4th Edition. Lyon, France: IARC Press; 2008.
2.
Chaudhry MS, Mather H, Marks A, Naresh K. Diffuse large B cell lymphoma complicating total knee arthroplasty: case report and literature review of the association of diffuse large B cell lymphoma with joint replacement. Acta Haematol. 2011;126(3):141–6. doi:10.​1159/​000328202.CrossRefPubMed
3.
4.
Tong MY, Zhang X, Yu Z, Sun XH, Li S, Zhang Y. Primary sternum diffuse large B-cell lymphoma: a case report and review of the literature. Oncol Lett. 2015;9(6):2623–8. Epub 2015 Apr 16.PubMedPubMedCentral
5.
6.
7.
Sanchez-Gonzalez B, Garcia M, Montserrat F, Sanchez M, Angona A, Solano A, Salar A. Diffuse large B-cell lymphoma associated with chronic inflammation in metallic implant. J Clin Oncol. 2013;31(10):e148–51. doi:10.​1200/​JCO.​2012.​42.​8250. Epub 2013 Feb 11.CrossRefPubMed
8.
Cheuk W, Chan AC, Chan JK, Lau GT, Chan VN, Yiu HH. Metallic implant-associated lymphoma: a distinct subgroup of large B-cell lymphoma related to pyothorax-associated lymphoma? Am J Surg Pathol. 2005;29(6):832–6.CrossRefPubMed
9.
Eskander MS, McPhee E, Eskander JP, Nascimento R, McCormick JJ, Hao S, Shepro D, Johnson K. A left knee wound complication by non-Hodgkins lymphoma in bilateral total knee arthroplasties. Arch Orthop Trauma Surg. 2008;128(12):1387–90. doi:10.​1007/​s00402-008-0568-z. Epub 2008 Jan 23.CrossRefPubMed
10.
Ganapathi M, Lake DN, Griffiths AP. Periprosthetic high-grade B-cell lymphoma complicating an infected revision total hip arthroplasty. J Arthroplasty. 2001;16(2):229–32.CrossRefPubMed
11.
O’Shea K, Kearns SR, Blaney A, Murray P, Smyth HA, McElwain JP. Periprosthetic malignancy as a mode of failure in total hip arthroplasty. J Arthroplasty. 2006;21(6):926–30.CrossRefPubMed
12.
13.
McDonald I. Malignant lymphoma associated with internal fixation of a fractured tibia. Cancer. 1981;48(4):1009–11.CrossRefPubMed
14.
Ladon D, Doherty A, Newson R, Turner J, Bhamra M, Case CP. Changes in metal levels and chromosome aberrations in the peripheral blood of patients after metal-on-metal hip arthroplasty. J Arthroplasty. 2004;19(8 Suppl 3):78–83.CrossRefPubMed
15.
Gross A, Joller-Jemelka HI, Wicki AN, Grob PJ. Hepatitis serological finding “anti-HBc alone”, circulating viral DNA and interpretation of findings. Schweiz Med Wochenschr. 1993;123(23):1193–202.PubMed
16.
Ulcickas Yood M, Quesenberry Jr CP, Guo D, Caldwell C, Wells K, Shan J, Sanders L, Skovron ML, Iloeje U, Manos MM. Incidence of non-Hodgkin’s lymphoma among individuals with chronic hepatitis B virus infection. Hepatology. 2007;46(1):107–12.CrossRefPubMed
17.
Abe SK, Inoue M, Sawada N, Iwasaki M, Shimazu T, Yamaji T, Sasazuki S, Tanaka Y, Mizokami M, Tsugane S, JPHC Study Group. Hepatitis B and C virus infection and risk of lymphoid malignancies: a population-based cohort study (JPHC Study). Cancer Epidemiol. 2015;39(4):562–6. doi:10.​1016/​j.​canep.​2015.​06.​002. Epub 2015 Jul 3.CrossRefPubMed
18.
Deng L, Song Y, Young KH, Hu S, Ding N, Song W, Li X, Shi Y, Huang H, Liu W, Zheng W, Wang X, Xie Y, Lin N, Tu M, Ping L, Ying Z, Zhang C, Sun Y, Zhu J. Hepatitis B virus-associated diffuse large B-cell lymphoma: unique clinical features, poor outcome, and hepatitis B surface antigen-driven origin. Oncotarget. 2015;6(28):25061–73. doi: 10.18632/oncotarget.4677.CrossRefPubMedPubMedCentral
19.
Wang F, Xu RH, Han B, Shi YX, Luo HY, Jiang WQ, Lin TY, Huang HQ, Xia ZJ, Guan ZZ. High incidence of hepatitis B virus infection in B-cell subtype non-Hodgkin lymphoma compared with other cancers. Cancer. 2007;109(7):1360–4.CrossRefPubMed
20.
21.
Metadata
Title
Case Report: Epstein-Barr-Virus negative diffuse large B-cell lymphoma detected in a peri-prosthetic membrane 
Authors
Sandra Sunitsch
Magdalena Gilg
Karl Kashofer
Andreas Leithner
Bernadette Liegl-Atzwanger
Christine Beham-Schmid
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2016
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-016-0533-z

Other articles of this Issue 1/2016

Diagnostic Pathology 1/2016 Go to the issue

Case Report

Primary mucinous carcinoma with rhabdoid cells of the thyroid gland: a case report

Case Report

Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study

Case Report

Clinicopathological features of idiopathic membranous nephropathy combined with IgA nephropathy: a retrospective analysis of 9 cases

Review

Poorly differentiated clusters (PDC) in colorectal cancer: what is and ought to be known

Research

Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer

Research

Analysis of epithelial-mesenchymal transition markers in the histogenesis of hepatic progenitor cell in HBV-related liver diseases