Skip to main content
Top
Published in: Diagnostic Pathology 1/2015

Open Access 01-12-2015 | Case report

Multifocal sclerosing angiomatoid nodular transformation of the spleen: a case report and review of literature

Authors: Zhixin Cao, Qiangxiu Wang, Jiamei Li, Jiawen Xu, Jianfeng Li

Published in: Diagnostic Pathology | Issue 1/2015

Login to get access

Abstract

Sclerosing angiomatoid nodular transformation (SANT) is a relatively new entity in the spleen, which usually presents in the form of single nodule. Only 5 multifocal SANT cases have been reported in English literature. The present case is the first report of a 38-years-old male patient with SANT in the form of multiple nodules, who has been cured via laparoscope. In comparison to solitary SANT, multifocal SANT occurs more likely in males than females and association with malignant neoplasm has not been described yet. Multifocal SANT as well as solitary SANT show some relationships with IgG4-related sclerosing disease.
Appendix
Available only for authorised users
Literature
1.
go back to reference Diebold J, Le TA, Marmey B, Prevot S, Muller-Hermelink HK, Sevestre H, et al. Is sclerosing angiomatoid nodular transformation (SANT) of the splenic red pulp identical to inflammatory pseudotumor? Report of 16 cases. Histopathology. 2008;53(3):299–310. PMID: 18643852.PubMedCrossRef Diebold J, Le TA, Marmey B, Prevot S, Muller-Hermelink HK, Sevestre H, et al. Is sclerosing angiomatoid nodular transformation (SANT) of the splenic red pulp identical to inflammatory pseudotumor? Report of 16 cases. Histopathology. 2008;53(3):299–310. PMID: 18643852.PubMedCrossRef
2.
go back to reference Kuo TT, Chen TC, Lee LY. Sclerosing angiomatoid nodular transformation of the spleen (SANT): clinicopathological study of 10 cases with or without abdominal disseminated calcifying fibrous tumors, and the presence of a significant number of IgG4+ plasma cells. Pathol In. 2009;59(12):844–50. PMID: 20021608. Kuo TT, Chen TC, Lee LY. Sclerosing angiomatoid nodular transformation of the spleen (SANT): clinicopathological study of 10 cases with or without abdominal disseminated calcifying fibrous tumors, and the presence of a significant number of IgG4+ plasma cells. Pathol In. 2009;59(12):844–50. PMID: 20021608.
3.
go back to reference Lee JC, Lien HC, Hsiao CH. Coexisting sclerosing angiomatoid nodular transformation of the spleen with multiple calcifying fibrous pseudotumors in a patient. J Formos Med Assoc. 2007;106(3):234–9. PMID: 17389168.PubMedCrossRef Lee JC, Lien HC, Hsiao CH. Coexisting sclerosing angiomatoid nodular transformation of the spleen with multiple calcifying fibrous pseudotumors in a patient. J Formos Med Assoc. 2007;106(3):234–9. PMID: 17389168.PubMedCrossRef
4.
go back to reference Martel M, Cheuk W, Lombardi L, Lifschitz MB, Chan JK, Rosai J. Sclerosing angiomatoid nodular transformation (SANT): report of 25 cases of a distinctive benign splenic lesion. Am J Surg Pathol. 2004;28(10):1268–79. PMID: 15371942.PubMedCrossRef Martel M, Cheuk W, Lombardi L, Lifschitz MB, Chan JK, Rosai J. Sclerosing angiomatoid nodular transformation (SANT): report of 25 cases of a distinctive benign splenic lesion. Am J Surg Pathol. 2004;28(10):1268–79. PMID: 15371942.PubMedCrossRef
5.
go back to reference Falk GA, Nooli NP, Morris SG, Plesec TP, Rosenblatt S. Sclerosing Angiomatoid Nodular Transformation (SANT) of the spleen: Case report and review of the literature. Int J Surg Case Rep. 2012;3(10):492–500. PMID: 22858789.PubMedCentralPubMedCrossRef Falk GA, Nooli NP, Morris SG, Plesec TP, Rosenblatt S. Sclerosing Angiomatoid Nodular Transformation (SANT) of the spleen: Case report and review of the literature. Int J Surg Case Rep. 2012;3(10):492–500. PMID: 22858789.PubMedCentralPubMedCrossRef
6.
go back to reference Quirós JL, Manes L, Bonandini E, Vivaldi P, Dalla PP, Barbareschi M. Sclerosing angiomatoid nodular transformation of the spleen associated with thrombocytopenia. Pathologica. 2010;102(2):67–70. PMID: 23596760.PubMed Quirós JL, Manes L, Bonandini E, Vivaldi P, Dalla PP, Barbareschi M. Sclerosing angiomatoid nodular transformation of the spleen associated with thrombocytopenia. Pathologica. 2010;102(2):67–70. PMID: 23596760.PubMed
7.
go back to reference Budzyński A, Demczuk S, Kumiega B, Migaczewski M, Matłok M, Zub-Pokrowiecka A. Sclerosing angiomatoid nodular transformation of the spleen treated by laparoscopic partial splenectomy. Wideochir Inne Tech Malo Inwazyjne. 2011;6(4):249–55. PMID: 23255989.PubMedCentralPubMed Budzyński A, Demczuk S, Kumiega B, Migaczewski M, Matłok M, Zub-Pokrowiecka A. Sclerosing angiomatoid nodular transformation of the spleen treated by laparoscopic partial splenectomy. Wideochir Inne Tech Malo Inwazyjne. 2011;6(4):249–55. PMID: 23255989.PubMedCentralPubMed
8.
go back to reference Nagai Y, Hayama N, Kishimoto T, Furuya M, Takahashi Y, Otsuka M, et al. Predominance of IgG4+ plasma cells and CD68 positivity in sclerosing angiomatoid nodular transformation (SANT). Histopathology. 2008;53(4):495–8. PMID: 18752536.PubMedCrossRef Nagai Y, Hayama N, Kishimoto T, Furuya M, Takahashi Y, Otsuka M, et al. Predominance of IgG4+ plasma cells and CD68 positivity in sclerosing angiomatoid nodular transformation (SANT). Histopathology. 2008;53(4):495–8. PMID: 18752536.PubMedCrossRef
9.
go back to reference Watanabe M, Shiozawa K, Ikehara T, Kanayama M, Kikuchi Y, Ishii K, et al. A case of sclerosing angiomatoid nodular transformation of the spleen: correlations between contrast-enhanced ultrasonography and histopathologic findings. J Clin Ultrasound. 2014;42(2):103–7. PMID: 23712651.PubMedCrossRef Watanabe M, Shiozawa K, Ikehara T, Kanayama M, Kikuchi Y, Ishii K, et al. A case of sclerosing angiomatoid nodular transformation of the spleen: correlations between contrast-enhanced ultrasonography and histopathologic findings. J Clin Ultrasound. 2014;42(2):103–7. PMID: 23712651.PubMedCrossRef
10.
go back to reference Wang HL, Li KW, Wang J. Sclerosing angiomatoid nodular transformation of the spleen: report of five cases and review of literature. Chin Med J (Engl). 2012;125(13):2386–9. PMID: 22882867. Wang HL, Li KW, Wang J. Sclerosing angiomatoid nodular transformation of the spleen: report of five cases and review of literature. Chin Med J (Engl). 2012;125(13):2386–9. PMID: 22882867.
11.
go back to reference Raman SP, Singhi A, Horton KM, Hruban RH, Fishman EK. Sclerosing angiomatoid nodular transformation of the spleen (SANT): multimodality imaging appearance of five cases with radiology-pathology correlation. Abdom Imaging. 2013;38(4):827–34. PMID: 22926767.PubMedCrossRef Raman SP, Singhi A, Horton KM, Hruban RH, Fishman EK. Sclerosing angiomatoid nodular transformation of the spleen (SANT): multimodality imaging appearance of five cases with radiology-pathology correlation. Abdom Imaging. 2013;38(4):827–34. PMID: 22926767.PubMedCrossRef
12.
go back to reference Kornprat P, Beham-Schmid C, Parvizi M, Portugaller H, Bernhardt G, Mischinger HJ. Incidental finding of sclerosing angiomatoid nodular transformation of the spleen. Wien Klin Wochenschr. 2012;124(3–4):100–3. PMID: 22138761.PubMedCrossRef Kornprat P, Beham-Schmid C, Parvizi M, Portugaller H, Bernhardt G, Mischinger HJ. Incidental finding of sclerosing angiomatoid nodular transformation of the spleen. Wien Klin Wochenschr. 2012;124(3–4):100–3. PMID: 22138761.PubMedCrossRef
13.
go back to reference Kim HH, Hur YH, Koh YS, Kim JC, Kim HJ, Kim JW, et al. Sclerosing angiomatoid nodular transformation of the spleen related to IgG4 associated disease: report of a case. Surg Today. 2013;43(8):930–6. PMID: 23440358.PubMedCrossRef Kim HH, Hur YH, Koh YS, Kim JC, Kim HJ, Kim JW, et al. Sclerosing angiomatoid nodular transformation of the spleen related to IgG4 associated disease: report of a case. Surg Today. 2013;43(8):930–6. PMID: 23440358.PubMedCrossRef
14.
go back to reference Agrawal M, Uppin SG, Bh S, Suppin M, N B, Challa S: Sclerosing angiomatoid nodular transformation of the spleen: a new entity or a new name? Turk Patoloji Derg 2014, 9 [Epub ahead of print]. PMID: 24715557 Agrawal M, Uppin SG, Bh S, Suppin M, N B, Challa S: Sclerosing angiomatoid nodular transformation of the spleen: a new entity or a new name? Turk Patoloji Derg 2014, 9 [Epub ahead of print]. PMID: 24715557
15.
go back to reference Kim HJ, Kim KW, Yu ES, Byun JH, Lee SS, Kim JH, et al. Sclerosing angiomatoid nodular transformation of the spleen: clinical and radiologic characteristics. Acta Radiol. 2012;53(7):701–6. PMID: 22843838.PubMedCrossRef Kim HJ, Kim KW, Yu ES, Byun JH, Lee SS, Kim JH, et al. Sclerosing angiomatoid nodular transformation of the spleen: clinical and radiologic characteristics. Acta Radiol. 2012;53(7):701–6. PMID: 22843838.PubMedCrossRef
16.
go back to reference Gómez RM, López CA, Rendón P, Muñoz BA, Macías M, Garre C, et al. Safety and diagnostic accuracy of percutaneous ultrasound-guided biopsy of the spleen: a multicenter study. J Clin Ultrasound. 2009;37(8):445–50.CrossRef Gómez RM, López CA, Rendón P, Muñoz BA, Macías M, Garre C, et al. Safety and diagnostic accuracy of percutaneous ultrasound-guided biopsy of the spleen: a multicenter study. J Clin Ultrasound. 2009;37(8):445–50.CrossRef
17.
go back to reference Sammon J, Twomey M, Crush L, Maher MM, O’Connor OJ. Image-guided percutaneous splenic biopsy and drainage. Semin Intervent Radiol. 2012;29(4):301–10. PMID: 24293803.PubMedCentralPubMedCrossRef Sammon J, Twomey M, Crush L, Maher MM, O’Connor OJ. Image-guided percutaneous splenic biopsy and drainage. Semin Intervent Radiol. 2012;29(4):301–10. PMID: 24293803.PubMedCentralPubMedCrossRef
18.
go back to reference Li L, Fisher DA, Stanek AE. Sclerosing angiomatoid nodular transformation (SANT) of the spleen: addition of a case with focal CD68 staining and distinctive CT features. Am J Surg Pathol. 2005;29(6):839–41. PMID: 15897756.PubMedCrossRef Li L, Fisher DA, Stanek AE. Sclerosing angiomatoid nodular transformation (SANT) of the spleen: addition of a case with focal CD68 staining and distinctive CT features. Am J Surg Pathol. 2005;29(6):839–41. PMID: 15897756.PubMedCrossRef
Metadata
Title
Multifocal sclerosing angiomatoid nodular transformation of the spleen: a case report and review of literature
Authors
Zhixin Cao
Qiangxiu Wang
Jiamei Li
Jiawen Xu
Jianfeng Li
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2015
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-015-0312-2

Other articles of this Issue 1/2015

Diagnostic Pathology 1/2015 Go to the issue

Letter to the Editor

More on hepatic granulomas